An implantable zinc-based alloy surface structure and its preparation method and application

A surface structure and zinc alloy technology, which is applied in metal material coating process, liquid chemical plating, surgery, etc., can solve the problems of unguaranteed phosphate film composition, poor biocompatibility and complex composition of zinc hydroxide, etc. Achieve the effects of adjustable degradation rate, accelerated bone healing, and increased proliferation rate

Active Publication Date: 2022-06-28
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The problem is that the solution contains nickel, manganese and other components, so that the final phosphate coating contains 0.5-3wt.% nickel, which is very harmful to the human body
The problem is that the composition of the surface regulator containing zinc phosphate is relatively complex, and the optimal pH is 7-10. Under the condition of overbasicity, the zinc ion reaches a saturated state, and it is easy to form precipitation in the form of zinc hydroxide, which cannot be guaranteed. The composition of the phosphate film layer, and the zinc hydroxide contained in it is poorly biocompatible

Method used

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  • An implantable zinc-based alloy surface structure and its preparation method and application
  • An implantable zinc-based alloy surface structure and its preparation method and application
  • An implantable zinc-based alloy surface structure and its preparation method and application

Examples

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Embodiment 1

[0039] In this example, pure zinc is used as the substrate, and the wires are connected by micro-arc oxidation. The micro-arc oxidation voltage is 450V, and the micro-arc oxidation is performed for 15 minutes to obtain a surface porous structure; In the reaction kettle of the sodium calcium and phosphorus precursor liquid (20mL), the content of the calcium nitrate and sodium dihydrogen phosphate were 3.94g and 1.19g respectively, dissolved in 100mL of water, and the calcium to phosphorus mass ratio was 1.67. The reaction temperature was 110 °C and the reaction time was 16 hours to obtain an implantable zinc-based alloy surface structure, such as figure 1 As shown, the surface cross-sectional structure and morphology of the zinc-based alloy prepared in Example 1, (a) is a porous oxide layer, with uniform pores, small surface roughness, and slight cracks; it can be seen from the cross-section (b) that the porous The oxide layer is well bonded to the substrate; (c) (d) are the po...

Embodiment 2

[0045] In this example, a zinc-lithium alloy is used as the matrix, Zn: 99.5 wt.%, Li: 0.5 wt.%, micro-arc oxidation after connecting wires, the micro-arc oxidation voltage is 450V, and the micro-arc oxidation is 15 minutes to obtain a surface porous structure; The obtained surface porous structure is put into the reactor containing the calcium and phosphorus precursor liquid (20mL) of calcium nitrate and sodium dihydrogen phosphate, and the content of described calcium nitrate and sodium dihydrogen phosphate is respectively 4.28g, 1.19g , dissolved in 100mL of water, the mass ratio of calcium to phosphorus: 1.8. The reaction temperature was 110 °C and the reaction time was 16 hours to obtain an implantable zinc-based alloy surface structure, such as Figure 4 As shown, the surface porous structure is as Figure 4 As shown in (a), the pores are uniform, the surface roughness is small, and there are slight cracks; the calcium phosphate layer is as Figure 4 As shown in (b), t...

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Abstract

The invention discloses an implantable zinc-based alloy surface structure. The implantable zinc-based alloy surface structure includes a substrate and a porous zinc oxide layer formed on the surface of the substrate, and calcium and phosphorus are loaded on the surface of the porous zinc oxide layer. Salt layer; the substrate is zinc or zinc alloy. The zinc-based alloy surface structure has high biocombinability, can be quickly degraded and absorbed by human tissue, and is conducive to cell growth and high structural stability. The invention also discloses an implantable zinc-based alloy surface structure The preparation method is simple and easy, and can regulate the thickness of the surface structure of the zinc-based alloy. The invention also discloses the application in fixing bone healing. This structure can be quickly degraded and absorbed by human tissue, and combined with osteoblasts, it is beneficial to the growth of cells and accelerates bone healing.

Description

technical field [0001] The invention relates to the technical field of surface treatment of metal materials, in particular to an implantable zinc-based alloy surface structure and a preparation method and application thereof. Background technique [0002] The application of biodegradable alloys to human implants can avoid the risk of secondary surgical removal. In recent years, zinc alloys have been regarded as promising medical alloys, showing good application prospects. First of all, as an essential trace element for the human body, zinc participates in a variety of cellular metabolic processes in the human body, and plays an important role in regulating the normal growth and development of the human body, wound healing, immune function, and sense of taste. The recommended daily dietary intake of zinc is 2-10 mg, with a maximum intake of 40 mg, but above this value still does not cause significant toxicity. Therefore, zinc alloys have good biosafety as degradable medical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/14C22C18/00C23C18/12C25D11/34
CPCA61L31/088A61L31/086A61L31/146A61L31/14A61L31/148C22C18/00C25D11/34C23C18/1208
Inventor 杨丽景史义轩宋振纶朱兴隆黄涛王中琪
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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