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Preparation method of betaine type zwitterionic polymer

A zwitterionic and polymer technology, applied in the field of ionic polymer preparation, can solve the problems of reduced improvement effect and poor inhibition effect of polyethylene glycol, and achieve the effects of improving resistance effect, improving inhibitory effect and improving antibacterial effect.

Active Publication Date: 2021-09-03
SHIJIAZHUANG SAN TAI CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] When the existing zwitterionic polymers are used, they will be affected by the non-specific adsorption of proteins, which will lead to the adsorption of proteins on the surface of the material. Therefore, polyethylene glycol is usually added to improve the ability to resist non-specific adsorption, but The added polyethylene glycol is easily affected by oxidation and its improvement effect is reduced. Therefore, it needs to be modified to improve the ability to resist non-specific adsorption; in addition, for fungi such as mold and yeast, zwitterions Polymers have poor inhibitory effect on it and urgently need to be improved

Method used

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  • Preparation method of betaine type zwitterionic polymer
  • Preparation method of betaine type zwitterionic polymer
  • Preparation method of betaine type zwitterionic polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] S1. Take 99.0mg of CBAA, and pour it into a three-neck flask, then add an appropriate amount of glycidyl methacrylate, shake and shake well;

[0025] S2. Take 20 mg of cross-linking agent N, N'-methylenebisacrylamide, 20 μL of initiator azobisisobutyronitrile and 5 μL of accelerator TEMED, and add them to the reaction system in sequence;

[0026] S3, then add 20mL of dioxane to dissolve, and ultrasonicate at 45°C for 6 minutes to disperse evenly, then add 1.05g of modified polyethylene glycol and 8mL of antibacterial extract, shake to dissolve completely;

[0027] S4. Introduce nitrogen for 18 minutes, then heat to 70°C at a uniform speed, and react the mixture in the three-necked flask for 13 hours under nitrogen atmosphere. After the reaction, use acetone and ether to purify. The amount of acetone is 1500mL, and the amount of ether is 500mL. The product was washed three times with acetone, then washed once with ether, dried in vacuum, and crushed to obtain a white pow...

Embodiment 2

[0029] S1. Take 99.4mg of CBAA, and pour it into a three-neck flask, then add an appropriate amount of glycidyl methacrylate, shake and shake well;

[0030] S2. Take 21 mg of cross-linking agent N, N'-methylenebisacrylamide, 21 μL of initiator azobisisobutyronitrile, and 6 μL of accelerator TEMED, and add them to the reaction system in sequence;

[0031] S3. Then add 21mL of dioxane to dissolve, and ultrasonicate at 45°C for 6 minutes to make it evenly dispersed, then add 1.07g of modified polyethylene glycol and 11mL of antibacterial extract, shake to dissolve completely;

[0032] S4. Introduce nitrogen for 18 minutes, then heat to 70°C at a uniform speed, and react the mixture in the three-necked flask for 13 hours under nitrogen atmosphere. After the reaction, use acetone and ether to purify. The amount of acetone is 1500mL, and the amount of ether is 500mL. The product was washed three times with acetone, then washed once with ether, dried in vacuum, and crushed to obtain ...

Embodiment 3

[0034] S1. Take 99.8mg of CBAA, and pour it into a three-neck flask, then add an appropriate amount of glycidyl methacrylate, shake and shake well;

[0035] S2. Take 22 mg of cross-linking agent N, N'-methylenebisacrylamide, 22 μL of initiator azobisisobutyronitrile, and 7 μL of accelerator TEMED, and add them to the reaction system in sequence;

[0036] S3, then add 22mL of dioxane to dissolve, and ultrasonicate at 45°C for 6 minutes to make it evenly dispersed, then add 1.09g of modified polyethylene glycol and 8mL of antibacterial extract, shake to dissolve completely;

[0037] S4. Introduce nitrogen for 18 minutes, then heat to 70°C at a uniform speed, and react the mixture in the three-necked flask for 13 hours under nitrogen atmosphere. After the reaction, use acetone and ether to purify. The amount of acetone is 1500mL, and the amount of ether is 500mL. The product was washed three times with acetone, then washed once with ether, dried in vacuum, and crushed to obtain a...

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Abstract

The invention relates to the technical field of ionic polymer preparation, in particular to a preparation method of a betaine type zwitterionic polymer. The method comprises the following steps: S1, taking 99.0-99.8 mg of zwitter-ions, pouring the zwitter-ions into a three-neck flask, then adding a proper amount of glycidyl methacrylate, and shaking the flask uniformly; s2, sequentially adding 20-22 mg of a cross-linking agent, 20-22 [mu] L of an initiator and 5-7 [mu] L of an accelerant into the reaction system; and S3, then adding 20-22 mL of dioxane for dissolving, carrying out ultrasonic treatment for 5-7 minutes at the temperature of 45-55 DEG C so as to uniformly disperse the dioxane, then adding 1.05-1.09 g of modified polyethylene glycol and 8-15 mL of an antibacterial extracting solution, and oscillating the solution so as to completely dissolve the substances. According to the invention, not only can the resisting effect on nonspecific adsorption of protein be improved, but also the antibacterial effect of the ionic polymer can be improved.

Description

technical field [0001] The invention relates to the technical field of ion polymer preparation, in particular to a preparation method of betaine type zwitterionic polymer. Background technique [0002] Zwitterionic polymers have both positive and negative charges in their repeating units, which have a fixed number of charges and good hydration capacity. Zwitterionic polymers with both positive and negative charge groups on the polymer chain have been highly valued by scholars in related fields because of their inverse polyelectrolyte effect and isoelectric point phenomenon. And the expansion of its molecular chain in aqueous solution is not affected by the ionic strength and pH value of the solution, and has better salt resistance. [0003] When the existing zwitterionic polymers are used, they will be affected by the non-specific adsorption of proteins, which will lead to the adsorption of proteins on the surface of the material. Therefore, polyethylene glycol is usually a...

Claims

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Application Information

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IPC IPC(8): C08F283/06C08F251/00C08F220/36C08F220/32C08F222/38C08F2/44C08K5/134C08K5/08
CPCC08F283/06C08F251/00C08F2/44C08K5/1345C08K5/08C08F220/365C08F220/325C08F222/385Y02A50/30
Inventor 刘鹏张茜葛建民田丽霞张民王军
Owner SHIJIAZHUANG SAN TAI CHEM CO LTD
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