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Application of Baitouweng decoction in preparation of medicine for treating pneumonia

A technique of Pulsatilla decoction and Pulsatilla, applied in the field of biomedicine

Pending Publication Date: 2021-09-10
广东安道医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no relevant report on the use of Pulsatilla Decoction in the treatment of pneumonia

Method used

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  • Application of Baitouweng decoction in preparation of medicine for treating pneumonia
  • Application of Baitouweng decoction in preparation of medicine for treating pneumonia
  • Application of Baitouweng decoction in preparation of medicine for treating pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation method of Pulsatilla Decoction, concrete steps are as follows:

[0044] According to the drug dose in "Treatise on Febrile Diseases", weigh the following raw materials respectively:

[0045] Pulsatilla 30g, Phellodendron 45g, Coptis 45g, Qinpi 45g;

[0046] All the raw materials are placed in a casserole, and the pulsatilla soup is prepared according to the following steps:

[0047] (1) Soak in 12 times the weight of distilled water for 2 hours, heat to boil on high heat, and then change to slow fire to heat after boiling; start timing from the time of boiling, filter the medicinal residue with gauze after 1 hour, and collect the water decoction.

[0048] (2) Add distilled water 10 times the weight of the raw material to the dregs obtained in the above steps, heat on high fire until boiling, then change to slow fire for 1 hour, filter with gauze, and collect the decoction.

[0049] (3) Repeat step (2), add distilled water 8 times the weight of the raw ...

Embodiment 2

[0052] The protective effect of embodiment 2 Pulsatillae decoction on mouse pneumonia induced by influenza A virus H1N1

[0053]H1N1 virus-induced pneumonia is a well-characterized, reproducible, and highly similar pneumonia model that can be used to test the therapeutic potential of BTWD.

[0054] Source of influenza A virus H1N1: provided by the Department of Microbiology and Immunology, School of Medicine, Jinan University;

[0055] Take male Balb / c mice with a body weight of 22 ± 2g, 60 in total, and randomly divide them into 6 groups, 10 in each group, respectively blank control group (Con), influenza A virus H1N1 model group (H1N1), pulsatilla Decoction BTWD low (H1N1+BL, 3.5g / kg crude drug dose), medium (H1N1+BM, 7g / kg), high (H1N1+BH, 14g / kg) dose group, dexamethasone positive drug control group (DEX, 5mg / kg).

[0056] The mice were pre-administered after 7 days of adaptive feeding. Each mouse in each treatment group was given the Pulsatilla decoction prepared in Exa...

Embodiment 3

[0064] Example 3 Pulsatilla decoction inhibits H1N1-induced pneumonia inflammatory response

[0065] By enzyme-linked immunosorbent assay (enzyme-linked immunosorbent assay, ELISA), the level of each pro-inflammatory factor in the BALF and serum of each group in Example 2 is measured, and the results are shown in the attached Figure 5 , 6 Shown:

[0066] BTWD decreased the expression levels of IL-6, IL-1β and TNF-α in BALF, and also decreased the expression levels of IL-6, IL-1β and TNF-α in serum. The above results indicated that BTWD suppressed the H1N1-mediated upregulation of TNF-α, IL-6 and IL-1β in pneumonia mice, that is, BTWD suppressed the inflammatory response of pneumonia in mice, similar to that observed in histopathology and microvascular permeability analysis The protective effect of BTWD on treatment-related pneumonia, and its mode of action may be dose-dependent.

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Abstract

The invention discloses application of Baitouweng decoction in preparation of a medicine for treating pneumonia, and belongs to the technical field of biological medicines. The Baitouweng decoction comprises the following raw materials in parts by weight of 2 parts of radix pulsatillae, 3 parts of cortex phellodendri, 3 parts of coptis chinensis and 3 parts of cortex fraxini. The Baitouweng decoction disclosed by the invention can maintain the integrity of alveolar-vascular barrier, relieve pulmonary edema and cell injury, inhibit pneumonia inflammatory response, inhibit cell apoptosis and regulate and control a TLR4 / NF-kappa B signal channel, is used for preparing the medicine for treating the pneumonia, and has a remarkable curative effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of Pulsatilla Decoction in the preparation of medicines for treating pneumonia. Background technique [0002] Pneumonia (pneumonia) refers to the inflammation of the terminal airways, alveoli and pulmonary interstitium, which can be caused by pathogenic microorganisms, physical and chemical factors, immune damage, allergies and drugs. [0003] Among them, bacterial pneumonia is directly invaded by the bacteria itself, or the toxins and enzymes produced by them cause tissue necrosis and inflammatory reactions. Carry out research work on anti-bacterial pneumonia drugs. [0004] Viral pneumonia is an inflammation caused by various types of virus infection. It often manifests as symptoms of upper respiratory tract infection such as fever, cough, sputum, and sore throat, accompanied by general muscle pain and joint pain. Some patients may develop secon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P11/00A61P29/00A61P31/16
CPCA61K36/71A61K36/756A61K36/718A61K36/63A61K9/0095A61P11/00A61P29/00A61P31/16A61K2236/331A61K2236/39A61K2300/00
Inventor 舒尊鹏钟仁兴王毅张涵彭明明陈莹李伟夏天乙商立峰
Owner 广东安道医疗器械有限公司
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