Clostridium composition with weight-losing and lipid-lowering functions and preparation method thereof

A Clostridium and composition technology, applied in the field of microbial preparations, can solve the problems of reducing lipid absorption, etc., and achieve the effects of reducing lipid absorption, weight loss, lowering cholesterol, and improving intestinal function

Inactive Publication Date: 2021-09-21
深圳市巨印科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As a control, the research team also conducted experiments on germ-free mice. The study found that the germ-free mice with the deletion...

Method used

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  • Clostridium composition with weight-losing and lipid-lowering functions and preparation method thereof
  • Clostridium composition with weight-losing and lipid-lowering functions and preparation method thereof
  • Clostridium composition with weight-losing and lipid-lowering functions and preparation method thereof

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preparation example Construction

[0039] According to another embodiment of the present invention, such as figure 1Shown, also provide the preparation method of the clostridium composition with fat-reducing functions for weight loss, the method comprises the following steps:

[0040] S1. Obtain two kinds of fermentation liquids by culturing caproic acid-producing Clostridium and Clostridium butyricum through seed culture and fermentation culture respectively;

[0041] S2. Centrifuge the fermented bacteria liquid and collect the bacteria sludge respectively, freeze-dry and pulverize the bacteria sludge to obtain two kinds of bacteria powder;

[0042] S3. Mixing the two bacterial powders with the bacterial powder carrier according to the ratio of parts by mass to obtain a mixture;

[0043] S4. Weighing red sage root, bilberry, black fruit wolfberry and purple sweet potato according to the ratio of parts by mass, soaking, sterilizing and drying to obtain dry powder;

[0044] S5. Obtaining oligopeptide 1 and oli...

Embodiment 1

[0061] The Clostridium composition prepared by the present invention and comparative example (select conventional probiotic composition) are carried out animal experiment, experimental process is as follows:

[0062] Select SD rats (body weight 200~220g) 40, divide into blank group, model group, composition group, contrast group at random according to body weight, each group has 10; Except blank group, all the other three groups are given modeling feed ( Basic feed 39%, lard 23%, sucrose 21%, egg yolk powder 9%, salt 8%); The blank group was given common feed, all 25g / bird / day, supplemented with common feed after eating, and each group had unlimited drinking water.

[0063] Among them, the composition group was given 0.3 g / kg body weight d of the Clostridium composition prepared by the present invention, the control group was given 0.3 g / kg body weight d of the conventional probiotic composition, and the blank group and the model group were given equal volumes of distil...

Embodiment 2

[0076] Choose the clostridia composition prepared by the present invention and comparative example (select conventional probiotic composition) to carry out human trial detection effect, experiment is as follows:

[0077] Test object: choose 20 volunteers, be divided into contrast group and experiment group, each group is 10 volunteers, the age is 23~45 years old, and experiment group volunteer uses composition of the present invention to smear evenly near navel every day, every day Once a day, apply continuously for 2 months; the control group uses conventional probiotic composition to apply evenly near the navel, once a day, apply continuously for 2 months.

[0078] Judging criteria: obvious: the weight loss is obvious, and the complexion is obviously improved; general: the weight is decreased, and the complexion is improved; invalid: the weight is not decreased or increased, and the complexion is not improved; diarrhea.

[0079] The experimental results are as follows:

[...

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Abstract

The invention discloses a clostridium composition with weight-losing and lipid-lowering functions and a preparation method thereof. The composition for losing weight and lowering lipid is prepared from the following raw materials in parts by mass: 5 to 8 parts of clostridium powder for producing hexanoic acid, 7 to 15 parts of clostridium butyricum powder, 0.01 part of oligopeptide I, 0.005 part of oligopeptide II, 2 to 5 parts of red sage root extract, 2 to 5 parts of vaccinium uliginosum extract, 2 to 5 parts of lycium ruthenicum extract, 2 to 5 parts of purple sweet potato, 15 to 20 parts of psyllium husk, 50 to 90 parts of medicinal corn starch and 7 to 11 parts of silicon dioxide. The composition has the beneficial effects that the lipid absorption can be reduced and the intestinal function can be improved under the action of the clostridium for producing hexanoic acid and clostridium butyricum; the oligopeptide I and the oligopeptide II are bioactive peptides, can inhibit adipogenesis, and have remarkable effects of losing weight and reducing cholesterol; the red sage root, the vaccinium uliginosum, the lycium ruthenicum and the purple sweet potato extract contain a lipase inhibitor and can reduce blood fat.

Description

technical field [0001] The invention relates to the technical field of microbial preparations, in particular to a Clostridium composition with functions of weight loss and fat reduction and a preparation method thereof. Background technique [0002] With the acceleration of industrialization and urbanization in various countries, the obesity rate in many countries in the world is showing an increasing trend year by year. The disease burden of obesity is impacting the medical and health system, and then gradually spread to all levels of society, economy, and culture. A comprehensive proposition. In 2015, there were about 603.7 million obese adults worldwide, and the prevalence of obesity was 12%. The 2002 "Nutrition and Health Survey of Chinese Residents" data is in accordance with the "Guidelines for the Prevention and Control of Overweight and Obesity in Chinese Adults" standard. The overweight rate of Chinese adults is 22.8%, and the obesity rate is 7.1%. The prevalence ...

Claims

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Application Information

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IPC IPC(8): A23L33/135A23L33/18A23L33/105A23L19/10
CPCA23L33/135A23L33/18A23L33/105A23L19/105A23V2002/00A23V2200/332A23V2200/3262A23V2250/21A23V2250/2106A23V2250/55A23V2250/5118A23V2250/1628
Inventor 魏晶
Owner 深圳市巨印科技有限公司
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