Sacubitril and valsartan sodium single-layer osmotic pump controlled release tablet and preparation method thereof

A technology of sacubitrilvaler and single-layer osmotic pump, which is applied in coatings, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of slow release rate and susceptibility to external environment, and reduce the Toxic and side effects, the effect of reducing the total dose of medication and reducing the frequency of medication
CN113456607AActive Publication Date: 2021-10-01南京康川济医药科技有限公司
6 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
南京康川济医药科技有限公司
Publication Date
2021-10-01

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a sacubitril and valsartan sodium single-layer osmotic pump controlled release tablet and a preparation method thereof. The single-layer osmotic pump controlled release tablet comprises a tablet core, a semi-permeable coating membrane and small drug release holes; the tablet core comprises the following components in percentage by weight: 53-92% of sacubitril valsartan sodium, 2-33% of suspending aid, 0-33% of penetration enhancer and 0.5-3% of lubricant; the semi-permeable coating membrane comprises 60-99% of a semi-permeable membrane forming material and 1-40% of a pore-foaming agent, and the weight of the coating is 3-10% of the weight of the tablet core; and the aperture of the small drug release holes is 0.6mm-1.5 mm. The sacubitril and valsartan sodium single-layer osmotic pump controlled release tablet is orally taken once a day, has stable blood concentration, and is not easily influenced by gastrointestinal tract environment.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The present invention belongs to the field of pharmaceutical preparations, and specifically, the present invention relates to a monolayer penetration pump controlled release tablet and its preparation method thereof. Background technique

[0002] Heart failure is a common disease in the clinic, the incidence rate is high, and has a continuous increase in trend, the disease is complex clinical syndrome caused by factors such as cardiac structure, functional abnormalities, divided into acute heart failure and chronic heart effort Failure. Among them, chronic heart failure is the end stage of the clinical center of vascular disease, which seriously affects the health of the patient, and reduces the quality of life. The main method of treating chronic congestive heart failure in the clinic is the drug, and common drugs are angiotensin II receptor antagonists.

[0003] Shatak Bamquaisa is a clinical angiotensin II receptor antagonist, which is a clinical first a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More