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Medical EVA catheter material with surface frosted effect as well as preparation method and application of medical EVA catheter material

A catheter and frosting technology, which is applied in the field of medical polymer material modification, can solve problems such as toxicity, TPE material is not resistant to fat, and the environment is not friendly

Pending Publication Date: 2021-10-08
合诚技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The current traditional medical infusion catheter material is polyvinyl chloride (PVC), which requires the addition of plasticizers. Studies have shown that plasticizers will be precipitated during use, and plasticizers have definite or potential toxicity to the human body.
In addition, PVC produces toxic vinyl chloride gas in the production and recycling process, and waste disposal by incineration is likely to produce highly toxic dioxins. Therefore, PVC materials are not friendly to the environment and are gradually banned by developed countries.
In addition, non-PVC TPE materials and TPU medical catheters are currently being developed in the market, but TPE materials are not resistant to corrosion by fat and protein solutions, and are only suitable for water infusions; while TPU materials are high in price and low in output, and are currently not suitable for general use.

Method used

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  • Medical EVA catheter material with surface frosted effect as well as preparation method and application of medical EVA catheter material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] (1) Preparation of ethylene-vinyl acetate copolymer graft: 100 parts of EVA with a melt index of 7g / 10min (190°C, 2160g) were added with 0.06 parts of di-tert-butyl peroxide DTBP and 0.62 parts of EVA. Maleic anhydride MAH, after mixing uniformly, is melted and mixed by a twin-screw extruder. The temperature of the extruder is set to 160°C. After cooling and pelletizing with an underwater pelletizer, it is dehydrated and dried to obtain a melt index of 190°C and 2160g. 4.8g / 10min, graft ratio of 0.5% ethylene-vinyl acetate copolymer maleic anhydride graft.

[0058] (2) By mass, 0.2 part of antioxidant (antioxidant 1010 and antioxidant 168 = mass ratio of 1:1 are mixed), 0.5 part of slip agent (oleic acid amide, polyester graft modified Organic silicone and polytetrafluoroethylene in a ratio of 1:7:2 by mass) and 10 parts of polyethylene (melt index measured at 190°C, 2160g is 2g / 10min) weighing, high speed (800r / min) After mixing evenly, it is put into a twin-screw ext...

Embodiment 2

[0063] (1) Preparation of ethylene-vinyl acetate copolymer graft: 100 parts of EVA with a melt index of 7g / 10min (190° C., 2160g) were added with 0.08 parts of di-tert-butyl peroxide DTBP and 1.4 parts of EVA. Maleic anhydride MAH, mixed uniformly, melted and mixed by twin-screw extruder, the extruder temperature was set to 160°C, cooled and pelletized by an underwater pelletizer, and then dehydrated and dried to obtain a melt index at 190°C and 2160g. It is EVA-g-MAH with 3.5g / 10min and 1.0% grafting rate.

[0064] (2) By mass, 0.2 part of antioxidant (antioxidant 1010 and antioxidant 168 = mass ratio of 1:1 are mixed), 0.5 part of slip agent (oleic acid amide, polyester graft modified organic silicone and polytetrafluoroethylene in a mass ratio of 1:7:2) and 7 parts of propylene-based elastomer (melt index measured at 230°C, 2160g: 2.2g / 10min) Weighing at high speed (800r / min) After mixing evenly, put it into a twin-screw extruder, and obtain the auxiliary masterbatch thro...

Embodiment 3

[0069] (1) Preparation of ethylene-vinyl acetate copolymer graft: 100 parts of EVA with a melt index of 7g / 10min (190° C., 2160g) were added with 0.07 parts of di-tert-butyl peroxide DTBP and 1.1 parts of EVA. Maleic anhydride was mixed uniformly and then melted and mixed by a twin-screw extruder. The temperature of the extruder was set at 160°C. After cooling and pelletizing with an underwater pelletizer, the product was dehydrated and dried to obtain a melt index of 190°C and 2160g. 4.3g / 10min, EVA-g-MAH with a grafting rate of 0.8%.

[0070] (2) By mass, 0.2 part of antioxidant (antioxidant 1010 and antioxidant 168 = mass ratio of 1:1 are mixed), 0.5 part of slip agent (oleic acid amide, polyester graft modified silicone and polytetrafluoroethylene in a mass ratio of 1:7:2) and 3 parts of vinyl elastomer (density 0.908g / cm 3 , measured at 190°C and 2160g with a melt index of 1g / 10min), weighed at high speed (800r / min) and mixed evenly, put it into a twin-screw extruder, an...

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Abstract

The invention discloses a medical EVA catheter material with a surface frosted effect as well as a preparation method and application thereof. According to the invention, EVA is used as a main material, so that the material has proper flexibility and resilience; an antioxidant and a slipping agent are firstly mixed with a polyolefin component for granulation, and then are mixed with EVA in a master batch manner, so that the dispersion effect of the auxiliary agent is improved, and uniform dispersion is ensured; the polyolefin material forms a frosted effect, and the market requirements are met; long-chain nylon improves the corrosion resistance of the material and has better mechanical properties; and the graft of an ethylene-vinyl acetate copolymer improves the compatibility of the ethylene-vinyl acetate copolymer and the long-chain nylon. The prepared medical EVA catheter material is good in flexibility and resilience, free of plasticizer, safe and non-toxic, meets the requirements of catheters for conveying infusion medicines such as water aqua, fat emulsion and protein, is superior to similar products made of PVC and TPE materials in medicine compatibility and medicine application range, and ensures the health and safety of patients.

Description

technical field [0001] The invention belongs to the technical field of medical polymer material modification, and particularly relates to a medical EVA catheter material with a surface frosting effect, a preparation method and application thereof. Background technique [0002] The current traditional medical infusion catheter material is polyvinyl chloride (PVC), which requires the addition of plasticizers. Studies have shown that plasticizers will precipitate during use, and plasticizers have definite or potential toxicity to the human body. In addition, PVC produces toxic gas of vinyl chloride in the production and recycling process, and waste disposal is incinerated to easily produce highly toxic dioxins. Therefore, PVC materials are not environmentally friendly and are gradually banned by developed countries. In addition, the market is also developing non-PVC TPE materials and TPU medical catheters, but TPE materials are not resistant to fat and protein solution corrosio...

Claims

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Application Information

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IPC IPC(8): C08L23/08C08L77/02C08L51/06B29B9/06B29C48/92
CPCC08L23/0853B29B9/06B29C48/92B29C2948/9259B29C2948/92704C08L2205/035C08L2203/18C08L2205/025C08L2201/10C08L77/02C08L51/06Y02P20/54
Inventor 刘永焯龙木娣黄健诸泉蒋文真
Owner 合诚技术股份有限公司
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