Antidote composition and application thereof

A composition and drug technology, applied in the field of preparation of poisoning prevention and treatment drugs, can solve the problems of lack of organ protection, only focusing on removal of poisons and detoxification, poor prognosis of patients, etc.

Pending Publication Date: 2021-10-12
CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current common treatment plan only focuses on the removal of poison and detoxification, and lacks the protection of important organs of the body. In clinical practice, many patients, even those who receive timely treatment, do not consider the protection of tissues and organs in the treatment plan. poor prognosis

Method used

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  • Antidote composition and application thereof
  • Antidote composition and application thereof
  • Antidote composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Therapeutic effect on rats with acute organophosphate (dichlorvos) poisoning

[0032]Effects on the effect of non-lethal dose of dichlorvos: 72 healthy rats, half male and half male, were randomly divided into 6 groups according to sex and weight, 12 rats in each group, respectively normal control group, exposure group (30mg / kg dichlorvos), Drug exposure (30mg / kg dichlorvos) + levocarnitine 600mg / kg gavage treatment group, drug exposure (30mg / kg dichlorvos) + levocarnitine 600mg / kg intraperitoneal injection treatment group, drug exposure (30mg / kg dichlorvos) + pralidoxime chloride 30mg / kg injection treatment group, poison exposure (30mg / kg dichlorvos) + levocarnitine 600mg / kg injection + pradoxime chloride 30mg / kg injection treatment group. Except for the normal group, after fasting for 24 hours, the animals were given 30 mg / kg of dichlorvos by intragastric administration once, and the intragastric volume was 1 ml / 100 g. Corresponding drug treatment was give...

Embodiment 2

[0045] Embodiment 2: Therapeutic effect on metal (lead) poisoning mice

[0046] Seventy-two healthy and clean Kunming male mice born one week old, with a body weight of 10±2 grams, were randomly divided into 6 groups after adaptive feeding for 1 week, lead acetate model group, edetate disodium calcium group ( 75mg / kg, i.m), levocarnitine 100mg / kg, 200mg / kg, 400mg / kg group, edetate disodium calcium + levocarnitine 400mg / kg group, 12 rats in each group. The mice in the normal control group were given 0.4ml of deionized water, and the other groups were given 0.4ml of deionized water containing lead acetate (lead ion content 2mg / L). drug intervention. Continuous treatment for 14 days, 24 hours after the last intervention, blood was taken from the orbit, anticoagulated with heparin sodium, mixed with 4:1 (volume fraction) concentrated nitric acid / perchloric acid solution, heated and digested. Killed by neck dissection, quickly separated the right femur, removed its peripheral fat...

Embodiment 3

[0051] Embodiment 3: to the therapeutic effect of acute carbon monoxide poisoning rat

[0052] Acute carbon monoxide poisoning model establishment and drug intervention: 60 male SD rats, body weight 220-250 g, were divided into normal control group, acute CO poisoning group, levocarnitine 600mg / kg group, levocarnitine 600mg / kg+ In the trimetazidine 6 mg / kg group, there were 12 rats in the normal control group and 16 rats in the other groups. According to the method reported in the literature, the rats were placed in the exposure box, continuously inhaled CO with a concentration of 2 000 ppm for 35 min, and then continuously inhaled CO with a concentration of 3 000 ppm for 25 min before leaving the box; Air was continuously inhaled in the poison box for 1 h. Immediately after the exposure, the modified Rodkey FL microquantitative method was used to detect the blood carboxyhemoglobin concentration (COHb%). When COHb% > 40%, the model was considered successful. Rats in the trea...

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PUM

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Abstract

The invention discloses an antidote. The detoxifying medicine is prepared from one or more of levocarnitine, a levocarnitine derivative, a levocarnitine medicinal salt, a metabolic regulation medicine, an emetic, an oxidant, an adsorbent, a protective agent, a laxative, an organic phosphorus poisoning antidote, a metal poisoning antidote, a cyanide poisoning antidote, a methemoglobinemia antidote and a central nervous inhibitor antidote, a cholinesterase revivifier, a carbon monoxide poisoning antidote, an organic fluorine poisoning antidote, an alcoholism antidote, a bacterial poisoning antidote, a fungal poisoning antidote and an animal and plant-derived poisoning antidote. The antidote has the effects of promoting toxicant removal and protecting tissue and organ functions.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an antidote and the use of a composition containing the antidote in preparing poisoning prevention and treatment medicines. Background technique [0002] After a certain chemical substance from the outside enters the human body, it reacts with human tissue, causing temporary or permanent damage to the human body, which is called poisoning. Poisoning in life includes accidental poisoning, homicide poisoning (poisoning), suicide poisoning, poisoning caused by drug abuse, and poisoning caused by environmental pollution. Clinically, it can be divided into acute poisoning (onset within 24 hours after the poison enters the body), chronic poisoning (onset 2 months after the poison enters the body), and subacute poisoning (between acute and subacute poisoning). Among them, acute poisoning has a sudden onset and rapid development of the disease, causing damage to the functions of various organs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/205A61K31/221A61K45/06A61P39/02
CPCA61K31/205A61K31/221A61K45/06A61P39/02A61K2300/00
Inventor 谢和兵吕伟红顾书华
Owner CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST
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