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Adhesive bandage film, adhesive bandage and preparation method of adhesive bandage film

A band-aid and film-forming technology, which can be used in pharmaceutical formulations, medical preparations with inactive ingredients, and digestive systems, etc., and can solve problems such as oral hygiene effects, residual hazards, and absence of market costs.

Pending Publication Date: 2021-10-19
BEIJING PAISHENG BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The biggest disadvantage of this technology is that many chemicals are used in the preparation process of the product. As cross-linking or intermediate monomers, the residue of these substances is harmful to some extent.
Moreover, the technology has a three-layer structure, the process is too cumbersome, and there is no advantage in market cost
The main purpose of this technology is to prolong the duration of the drug in the oral cavity. However, if the drug carrier degrades for too long, some bacteria in the oral cavity will gather around the carrier, which will have a certain impact on oral hygiene.
But it's good for wound protection

Method used

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  • Adhesive bandage film, adhesive bandage and preparation method of adhesive bandage film
  • Adhesive bandage film, adhesive bandage and preparation method of adhesive bandage film
  • Adhesive bandage film, adhesive bandage and preparation method of adhesive bandage film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Step 1 prepares film-forming solution:

[0041] According to the ratio of 3 wt% and 10 wt%, weigh 3 g of hydroxyethyl cellulose (Shandong Jurong Biological Industry Co., Ltd.) and 10 g of glycerin, stir them well, add water to 100 g, and place in a water bath at 60 °C Stir evenly to form a clear and transparent solution, and stand for defoaming before use.

[0042] Step 2 Cross-linking to form a film:

[0043] Use a bottom area of ​​40 cm 2 , thickness 2 cm, cuboid stainless steel mold, take an appropriate amount of film-forming solution to cover the film, scrape it flat, dry at 45 ℃, and perform physical cross-linking to form a film. Add 50g and 100g of film-forming solution respectively, and adjust the film thickness by controlling different addition amounts to prepare films of 1mm and 2mm. After drying, the film is colorless, transparent, viscous and colloidal. When pressed by hand, the surface is very soft. After the pressure is removed, it can return to its orig...

Embodiment 2

[0061] Step 1 prepares film-forming solution:

[0062] According to the ratio of 2 wt% and 5 wt%, weigh 2 g of hydroxyethyl cellulose (Shandong Jurong Biological Industry Co., Ltd.) and 5 g of glycerin, stir them well, and add 10% functional excipients of HEC content Collagen 0.2g, add water to 100g, stir in a water bath at 60 ℃ to evenly form a light yellow clear and transparent solution, stand for defoaming and set aside for use.

[0063] Step 2 Cross-linking to form a film:

[0064] Use a bottom area of ​​40 cm 2 , thickness 2 cm, cuboid stainless steel mold, take an appropriate amount of film-forming solution to cover the film, scrape it flat, dry at 45°C, and perform physical cross-linking to form a film. After drying, the film is yellowish transparent and viscous gelatinous film. Compared with the film in Example 1, the 2:5 ratio film has a harder texture, but is still very soft and has no deformation after being stressed. The main reason for the yellowing of the pro...

Embodiment 3

[0081] Step 1 prepares film-forming solution:

[0082] Configure HEC and sodium carboxymethyl cellulose (Shanghai Changguang Enterprise Development Co., Ltd.) according to a mass ratio of 10:1, and mix to form a uniform solid component A. According to the ratio of 2 wt% and 10 wt%, take 2 g of component A and 10 g of glycerin, mix evenly and add water to 100 g, stir in a water bath at 60 °C to form a light yellow clear and transparent solution, and let it stand for defoaming before use.

[0083] Step 2 Cross-linking to form a film:

[0084] Use a bottom area of ​​40 cm 2 , thickness 2 cm, cuboid stainless steel mold, take an appropriate amount of film-forming solution to cover the film, scrape it flat, dry at 70°C, and perform physical cross-linking to form a film. After drying, the film is colorless, transparent, viscous and soft gelatinous film. Compared with the film in Example 1, the hardness is greater, and there is no deformation after being stressed.

[0085] Step 3...

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PUM

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Abstract

The invention relates to an adhesive bandage film, an adhesive bandage and a preparation method thereof. The adhesive bandage film is prepared through the following method including the steps that by taking the weight of an obtained film forming solution as 100%, 0.1 wt%-10 wt% of cellulose, 5 wt%-40 wt% of an oil-soluble solvent, 0 wt%-1 wt% of auxiliary materials and the balance water are mixed to be uniform, then heating and stirring are conducted, and the film forming solution is obtained; the auxiliary materials comprise one or more of collagen, an anti-inflammatory drug component, a preservative and vitamins; and the obtained film forming solution is dried to obtain the adhesive bandage. The obtained film has good viscosity and degradability.

Description

technical field [0001] The invention relates to a wound dressing film, a wound dressing and a preparation method thereof. Background technique [0002] At present, the wound plasters on the market are rarely used on oral wounds, mainly due to their stickiness, and the edible problem after degradation cannot be solved. There are hundreds of types of band-aids in the band-aid market, but more than 90% are used for wound protection on the skin surface. Others are used for human implantability, which cannot solve the above two problems. In recent years, it has emerged that oral ulcer patches can be effectively used on oral wounds, but the problems of stickiness and degradation have not been well resolved. [0003] CN201710945245.5 provides an adhesive film for oral ulcers, using polymer film-forming agents (chitosan, hydroxypropyl cellulose, sodium carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, etc.) It acts as a film, and after drying, it needs to be free to re...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/32A61K47/34A61K47/36A61K47/10A61K47/18A61P1/02
CPCA61K9/7007A61K47/38A61K47/32A61K47/34A61K47/36A61K47/10A61K47/18A61P1/02
Inventor 张自强符斌徐荣荣郭慧敏王兆丽辛介夫
Owner BEIJING PAISHENG BIOTECH CO LTD
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