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Preparation and application of polydopamine-encapsulated mesoporous silica nano-drug delivery system

A technology of mesoporous silica and polydopamine, which is applied in the fields of application, botany equipment and methods, and resistance to vector-borne diseases, and can solve problems such as increasing agricultural production costs, insufficient utilization of pesticides, and loss of pesticides

Active Publication Date: 2022-07-12
NANJING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional pesticides will enter the environment through leaf slipping, rain washing and volatilization during use, causing environmental pollution and pesticide losses. The utilization rate of pesticides is less than 10%, which increases the cost of agricultural production.

Method used

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  • Preparation and application of polydopamine-encapsulated mesoporous silica nano-drug delivery system
  • Preparation and application of polydopamine-encapsulated mesoporous silica nano-drug delivery system
  • Preparation and application of polydopamine-encapsulated mesoporous silica nano-drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of mesoporous silica nanoparticles

[0033] Add 100 mL of water to 700 mL of ethanol to form an aqueous ethanol solution, add 1.5 g of resorcinol, 2.1 mL (37 wt %) formaldehyde solution and 30 mL (28 wt %) ammonia water to the solution, stir vigorously for 6 h at room temperature, and add 6 mL of ortho-silicon Ethyl acid, after stirring for 8min, add 4g resorcinol and 5.6ml formaldehyde, continue to stir for 2h, centrifuge the precipitate, wash it with ethanol several times, dry at room temperature for 48h, transfer it to a crucible, put it in a muffle furnace The mesoporous silica nanoparticles were obtained by calcining at 550 °C for 5 h.

Embodiment 2

[0034] Example 2: Preparation of mesoporous silica nano-drug-loaded particles 1

[0035] Weigh 0.1g MSNs into 50mL ethanol solution, after ultrasonic dispersion, add 50mL (1g / L) chlorpyrifos ethanol solution, stir at room temperature for 24h, centrifuge at 12000rpm to collect the precipitate, wash with water at least three times, and freeze the precipitate After drying, the mesoporous silica nano-drug-loaded particles are obtained.

Embodiment 3

[0036] Example 3: Preparation of mesoporous silica nano-drug-loaded particles 2

[0037] Weigh 0.25g MSNs into 50mL ethanol solution, after ultrasonic dispersion, add 50mL (1g / L) chlorpyrifos ethanol solution, stir at room temperature for 24h, centrifuge at 12000rpm to collect the precipitate, wash with water at least three times, and freeze the precipitate After drying, the mesoporous silica nano-drug-loaded particles are obtained.

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Abstract

The invention discloses the preparation and application of a polydopamine-encapsulated mesoporous silica nanometer drug-carrying system, which belongs to the application development of nanotechnology in the agricultural field. The nano-drug loading system uses mesoporous silica nanoparticles as the carrier of the pesticide, and is formed by encapsulating polydopamine after adsorbing the pesticide. The nano-drug loading system described in the present invention has pH responsiveness and can promote the release of loaded pesticide molecules under alkaline conditions. The nano-drug-loading system has good photothermal conversion ability. Under the irradiation of near-infrared light, the temperature of the system is increased, which is beneficial to the release of pesticide components. Through the encapsulation of polydopamine, the nano-drug-loading system has good leaf adhesion properties and reduces the drop loss of pesticide droplets. In terms of biological activity, for herbivorous lepidopteran pests with an alkaline midgut microenvironment, it showed a highly effective insecticidal effect similar to that of commercial insecticides.

Description

technical field [0001] The patent of the present invention relates to the preparation and application of a polydopamine-encapsulated mesoporous silica nanometer drug-carrying system, which belongs to the application and development of nanotechnology in the agricultural field. Background technique [0002] Pesticides play a huge role in preventing and controlling diseases and insect pests and ensuring food production. The use of pesticides can restore 30% of global crop losses. However, traditional pesticides will enter the environment through leaf sliding, rain erosion and volatilization during use, causing environmental pollution and pesticide losses. The utilization rate of pesticides is less than 10%, which increases the cost of agricultural production. Therefore, improving the formulation of pesticides and improving the utilization rate of pesticides has become an urgent problem to be solved in the agricultural field. In recent years, the development and application of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N25/08A01N25/26A01N57/16A01P7/04
CPCA01N25/08A01N25/26A01N57/16Y02A50/30
Inventor 毛亮阚旗辉吴伟卢坤
Owner NANJING UNIV
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