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Copper and manganese-doped Prussian blue-like-molybdenum disulfide nano composite material as well as preparation and application thereof

A nanocomposite, Prussian blue-like technology, applied in the fields of nanotechnology, nanotechnology, nanomedicine, etc. for materials and surface science, can solve the problem of difficult to achieve synergistic therapy, low photothermal conversion efficiency, and low Fenton reaction efficiency. and other problems, to achieve the effect of enhancing CDT effect, high photothermal conversion efficiency, and improving hypoxia

Active Publication Date: 2021-11-02
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a Prussian blue-like molybdenum disulfide nanocomposite material doped with copper and manganese and its preparation and application, so as to solve the light-to-heat conversion efficiency of PB in the weakly acidic tumor microenvironment in the prior art Low, Fe 2+ / Fe 3+ Fenton reaction efficiency is low and / or difficult to achieve imaging-guided synergistic therapy and other defects

Method used

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  • Copper and manganese-doped Prussian blue-like-molybdenum disulfide nano composite material as well as preparation and application thereof
  • Copper and manganese-doped Prussian blue-like-molybdenum disulfide nano composite material as well as preparation and application thereof
  • Copper and manganese-doped Prussian blue-like-molybdenum disulfide nano composite material as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Preparation of copper-manganese-doped Prussian blue-molybdenum disulfide nanocomposites (CMPB-MoS 2 -PEG nanoparticles)

[0069] (1) Preparation of CMPB nanocubes

[0070] Take 50mg CuCl 2 2H 2 O, 60mg MnCl 2 4H 2 O and 105 mg of citric acid were dissolved in 20 mL of deionized water, heated to 60° C., and kept for 5 minutes to obtain solvent A for later use. Take 170mg K 4 [Fe(CN) 6 ]·3H 2 O and 84mg of citric acid were dissolved in 20mL of deionized water, heated to 60°C and kept for 5 minutes to obtain solvent B. Slowly add solvent B to solvent A dropwise, raise the temperature to 60°C, stir for 2 minutes, cool down, centrifuge to collect the precipitate, clean it ultrasonically with deionized water and ethanol for 2-3 times, and dry it in a vacuum oven at 60°C for 6 hours , to prepare CMPB nanocubes.

[0071] (2) Preparation of CMPB-MoS2 -PEG nanoparticles

[0072] Weigh 30 mg of CMPB nanocubes, 10 mg of ammonium tetrathiomolybdate and 10 mg of polyethyle...

Embodiment 2

[0074] CMPB-MoS 2 - Determination of the absorption peak of PEG nanocomposite particles in the near-red region

[0075] The CMPB-MoS obtained in embodiment 1 2 -PEG nanocomposite particles are dispersed in water, and their absorption peaks at near-infrared are measured with a UV-visible spectrophotometer, such as Figure 4 Shown, it is CMPB-MoS in embodiment 1 2 - Comparison of UV absorption of PEG nanocomposite and PB. It can be seen that compared with the pure PB material, the prepared CMPB-MoS 2 -PEG nanocomposites have strong and broad absorption peaks in the near-infrared region.

Embodiment 3

[0077] CMPB-MoS 2 -Photothermal properties of PEG nanocomposites

[0078] Get the CMPB-MoS obtained in Example 1 2 -PEG nanocomposite particles were dispersed in deionized water, and CMPB-MoS with concentrations of 0, 25 μg / mL, 50 μg / mL, 100 μg / mL, 200 μg / mL and 400 μg / mL were prepared in 200 μL centrifuge tubes, respectively. 2 - PEG nanocomposite particle solution. The series of solutions were irradiated with laser for 10min, and the irradiation power density was 1W / cm 2 , the wavelength is 808nm. Record the temperature of the solution at different time points, such as Figure 5 As shown, with the increase of irradiation time, the temperature of the solution increases gradually, and the higher the concentration, the faster the heating rate, indicating that the CMPB-MoS 2 - PEG nanocomposite particles have excellent light-to-heat conversion properties.

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Abstract

The invention relates to a copper and manganese-doped Prussian blue-like-molybdenum disulfide nano composite material as well as preparation and application thereof. The preparation process of the nano composite material comprises the following steps: (1) synthesizing a copper and manganese-doped Prussian blue-like CMPB nano cube through a coprecipitation method; (2) taking the CMPB nanocube, ammonium tetrathiomolybdate and polyethylene glycol as raw materials, and performing hydrothermal reaction to obtain a target product. The copper and manganese doped Prussian blue-like-molybdenum disulfide nano composite material prepared by the invention has a porous annular structure, provides a space for effectively delivering doxorubicin (DOX) to tumor tissues, can integrate enhanced photo-thermal and chemical kinetics treatment means, can achieve photo-thermal / chemical kinetics treatment / chemotherapy synergistic treatment of cancers, and can be used as a contrast agent of MR; in addition, the composite material can be degraded in a dependent manner on H2O2, and the long-term toxicity of the composite material on organisms can be reduced.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanocomposite particles, and in particular relates to a Prussian blue-like molybdenum disulfide nanocomposite material doped with copper and manganese and its preparation and application. Background technique [0002] Since the current main methods of treating cancer often lead to obvious side effects, in recent years, many nanomaterials have been developed as PTT preparations and CDT preparations, which have shown good therapeutic effects on tumors. Prussian blue (PB) has been approved by the US Food and Drug Administration (FDA) as a safe oral antidote because of its good biological safety. On the one hand, based on the C-Fe in the PB structure 2+ and N-Fe 3+ , which has good longitudinal and transverse relaxation rates and a high optical absorption peak at ~700 nm. Utilize Zn 2+ Ion-doped PB can enhance its light absorption or transfer absorption in the near-infrared (NIR) region, sh...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/704A61K47/02A61K49/08A61P35/00B82Y5/00B82Y40/00B82Y30/00
CPCA61K41/0052A61K41/0057A61K31/704A61K47/02A61K49/08A61P35/00B82Y5/00B82Y40/00B82Y30/00A61K2300/00
Inventor 管少琪刘锡建王星妍王金霞张子文曹东苗陆杰
Owner SHANGHAI UNIV OF ENG SCI
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