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Tibetan red yeast rice, Tibetan medicine red yeast rice extract, preparation method and application

A technology of extract and red yeast rice, applied in the field of fermentation, can solve the problems of less research and research on lovastatin components, and achieve the effects of good process stability, stable quality and small difference in components

Pending Publication Date: 2021-11-05
西藏月王药诊生态藏药科技有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

[0003] The active ingredients of traditional Chinese medicine red yeast rice for lowering blood lipids are lovastatins. As raw materials, their standards are attached to the item "Xuezhikang Capsules" recorded in the "Chinese Pharmacopoeia". less research

Method used

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  • Tibetan red yeast rice, Tibetan medicine red yeast rice extract, preparation method and application
  • Tibetan red yeast rice, Tibetan medicine red yeast rice extract, preparation method and application
  • Tibetan red yeast rice, Tibetan medicine red yeast rice extract, preparation method and application

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preparation example Construction

[0093] A preparation method of saffron red yeast rice, comprising:

[0094] (1) Highland barley, auxiliary materials, and nutrient solution are mixed according to the weight ratio (40-100): (5-60): (20-45) and then matured to obtain a fermentation substrate; in terms of weight ratio, the nutrient solution includes: sucrose 0.1-1 part, 0.2-1 part of glutamic acid, 0.01-0.26 part of histidine, 0.01-0.15 part of calcium nitrate, 0.01-0.15 part of sodium nitrate, 0.01-0.05 part of potassium dihydrogen phosphate, 0.01-0.05 part of n-octanoic acid , 0.1-0.5 parts of ascorbic acid, 0.00001-0.00005 parts of EDTA-disodium, 96-98.07 parts of water;

[0095] (2) Fermentation is carried out after inoculating the seed liquor of Monascus species in the fermentation substrate to obtain a fermented product;

[0096] (3) The fermented product is dried.

[0097] Preferably, the weight ratio of highland barley, auxiliary materials and nutrient solution is 88:12:40.

[0098] Preferably, the au...

Embodiment 1

[0141] Preparation of seed solution:

[0142] (1) Inoculate the Monascus strains in good growth state on the slope of the eggplant-shaped bottle, and culture them at 30°C for 6-7 days (refer to the specific operation: standard operating procedure for subculture and purification of strains XZYW-SOP-001-01) with 300ml sterile Spore suspension was made by water elution.

[0143] (2) The spore suspension is inoculated into a fermenter with an inoculum amount of about 1 wt%, cultivated at 30° C., dissolved oxygen 100%, and 140 r / min for 2-3 days as a seed liquid.

[0144] Monascus strains were inoculated into slant medium, cultured at 30°C for 6-7 days, and washed with water to obtain spore suspension;

[0145] The spore suspension is placed in a fermenter at 30° C. for 2-3 days for cultivation to obtain a seed liquid of Monascus species.

[0146] The preparation method of saffron red yeast rice:

[0147] (1a) Raw material processing: the highland barley raw material is screened...

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Abstract

The invention discloses Tibetan red yeast rice and a preparation method thereof. The preparation method comprises the steps that 1, highland barley, auxiliary materials and a nutrient solution are mixed and then cured, and a fermentation substrate is obtained, wherein the nutrient solution comprises the following components in parts by weight: cane sugar, glutamic acid, histidine, calcium nitrate, sodium nitrate, monopotassium phosphate, n-caprylic acid, ascorbic acid, EDTA-disodium and water; (2) the fermentation substrate is inoculatedwith a monascus strain seed solution, and fermented to obtain a fermented product; and (3) the fermented product is dried to obtain Tibetan red yeast rice. The preparation method is good in process stability, small in component difference between batches and stable in quality. The nutrient solution, the fermentation process and the drying process are optimized, the content of lovastatin in the Tibetan red yeast rice is increased, and meanwhile the content of acid lovastatin can be effectively increased.

Description

technical field [0001] The invention relates to the technical field of fermentation, in particular to a Tibetan red yeast rice extract, a preparation method and an application thereof. Background technique [0002] Red yeast rice is a commonly used lipid-lowering drug, which is fermented by Monascus. There are two kinds of red yeast rice drugs in clinical use, namely the traditional Chinese medicine "red yeast rice" and the Tibetan medicine "Tibetan red yeast rice". The traditional Chinese medicine "red yeast rice" is fermented with japonica rice as the base, and is also commonly known as "red yeast rice". There are red yeast decoction pieces and its patent medicines Xuezhikang capsule and Zhibituo capsule in clinical use; Tibetan medicine "Tibetan red yeast rice" (Original name: Highland Barley Red Yeast), fermented from the seed kernel of highland barley, a specialty crop in Tibetan areas of my country, as a substrate, and its decoction pieces are used clinically. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/062A23L33/10A23L31/00A61P3/06A61P1/16
Inventor 胡学民
Owner 西藏月王药诊生态藏药科技有限公司
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