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Nitrogen-and-sulfur co-doped Ti3C2-MXene nanosheet as well as preparation method and application thereof

A technology of nitrogen-sulfur co-doping and nano-sheets, which is applied in the field of nano-bio-sensing to achieve the effects of difficult operation, excellent peroxidase-like activity and high sensitivity

Active Publication Date: 2021-11-23
航大绿翼(天津)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

As far as we know, there are no published reports on the use of non-metal doped MXene as a mimetic enzyme to detect uric acid.

Method used

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  • Nitrogen-and-sulfur co-doped Ti3C2-MXene nanosheet as well as preparation method and application thereof
  • Nitrogen-and-sulfur co-doped Ti3C2-MXene nanosheet as well as preparation method and application thereof
  • Nitrogen-and-sulfur co-doped Ti3C2-MXene nanosheet as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A nitrogen-sulfur co-doped Ti 3 C 2 -The uric acid detection method that MXene nanosheet simulates peroxidase activity, comprises the following steps:

[0049] 1) Ti 3 C 2 - Preparation of MXene nanosheets

[0050] Slowly add 5 g of MAX phase ceramic powder into 50 mL of hydrofluoric acid with a mass fraction of 40%, and react with magnetic stirring at room temperature for 24 h at a stirring speed of 800 r / min. After the reaction, the centrifugal corrosion product was washed with water until the pH of the supernatant was > 6, then washed 5 times with absolute ethanol, and finally the product was placed in a vacuum oven at 60°C for 12 hours to obtain Ti 3 C 2 - MXene nanosheets.

[0051] 2) Nitrogen and sulfur co-doped Ti 3 C 2 - Preparation of MXene nanosheets

[0052] The obtained Ti in step 1) 3 C 2 -MXene nanosheets and thiourea were ground and mixed evenly at a mass ratio of 1:3, then placed in an Ar gas atmosphere furnace and heated to 500°C, kept for 4 ...

Embodiment 2

[0059] A nitrogen-sulfur co-doped Ti 3 C 2 -The uric acid detection method that MXene nanosheet simulates peroxidase activity, comprises the following steps:

[0060] 1) Ti 3 C 2 - Preparation of MXene nanosheets

[0061] Slowly add 8 g of MAX phase ceramic powder into 80 mL of hydrofluoric acid with a mass fraction of 50%, and react with magnetic stirring at room temperature for 12 h at a stirring speed of 1000 r / min. After the reaction, the centrifugal corrosion product was washed with water until the pH of the supernatant was > 6, and then washed 5 times with absolute ethanol, and finally the product was placed in a vacuum oven at 80°C for 15 hours to obtain Ti 3 C 2 - MXene nanosheets;

[0062] 2) Nitrogen and sulfur co-doped Ti 3 C 2 - Preparation of MXene nanosheets

[0063] The obtained Ti in step 1) 3 C 2 - MXene nanosheets and thiourea were ground and mixed evenly at a mass ratio of 1:2, then placed in an Ar gas atmosphere furnace and heated to 600°C, kept ...

Embodiment 3

[0069] A nitrogen-sulfur co-doped Ti 3 C 2 -The uric acid detection method that MXene nanosheet simulates peroxidase activity, comprises the following steps:

[0070] 1) Ti 3 C 2 - Preparation of MXene nanosheets

[0071] Slowly add 6 g of MAX phase ceramic powder into 70 mL of hydrofluoric acid with a mass fraction of 50%, and react with magnetic stirring at room temperature for 12 h at a stirring speed of 1000 r / min. After the reaction, the centrifugal corrosion product was washed with water until the pH of the supernatant was > 6, then washed 7 times with absolute ethanol, and finally the product was placed in a vacuum oven at 80°C for 15 hours to obtain Ti 3 C 2 - MXene nanosheets;

[0072] 2) Nitrogen and sulfur co-doped Ti 3 C 2 - Preparation of MXene nanosheets

[0073] The obtained Ti in step 1) 3 C 2 -MXene nanosheets and thiourea were ground and mixed evenly at a mass ratio of 1:4, then placed in an Ar gas atmosphere furnace and heated to 550°C, kept for 8 h...

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Abstract

The invention discloses a nitrogen-and-sulfur co-doped Ti3C2-MXene nanosheet as well as a preparation method and application thereof. The preparation method comprises the following steps: etching MAX-phase ternary layered carbide by using hydrofluoric acid to obtain Ti3C2-MXene; and then, with thiourea as a heteroatom source, synthesizing the nitrogen-and-sulfur co-doped Ti3C2-MXene nanosheet through a simple one-step method. The nanosheet has a unique two-dimensional layered structure, a large specific surface area and abundant heteroatom catalytic active sites, so the nanosheet shows excellent peroxidase-like activity. According to the method disclosed by the invention, two elements including nitrogen and sulfur can be successfully doped on Ti3C2-MXene in one step, so the problem of tedious step-by-step doping steps and the problem of secondary pollution caused by different doping sources are effectively solved, the nanosheet is endowed with Ti3C2-MXene peroxidase activity, the problems of high cost, long period and high operation difficulty of a traditional uric acid detection method can be solved, and the method has the advantages of convenience, rapidness, accuracy, high efficiency, low cost and the like; and the uric acid detection range of the nanosheet is 5-400 [mu] M, accurate quantitative detection in actual samples can be realized, and the application prospect of the nanosheet is wide.

Description

technical field [0001] The invention belongs to the technical field of nanometer biosensing, and relates to a nitrogen-sulfur co-doped Ti 3 C 2 -MXene nanosheet and its preparation method, and specifically discloses a nitrogen-sulfur co-doped Ti 3 C 2 -Uric acid detection method based on MXene nanosheets mimicking peroxidase activity. Background technique [0002] Uric acid is the main final compound of purine nucleotide by-products in human metabolism, and uric acid in body fluids is an important biomarker for many diseases. When the concentration of uric acid in the serum of men is greater than 0.42mM or greater than 0.36mM in women, hyperuricemia will result, and hyperuricemia is closely related to gout, arthritis, kidney disease and cardiovascular disease. Conventional uric acid detection methods are costly, long-term, and cumbersome to operate, which cannot meet the needs of convenient and fast daily detection. The use of enzyme-like active nanomaterials (nanozymes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B32/921G01N21/78B82Y30/00B82Y40/00
CPCC01B32/921G01N21/78B82Y30/00B82Y40/00C01P2004/80C01P2002/85C01P2004/03C12Q1/28C12Q1/62C04B35/5611C04B35/6262C04B35/6264C04B35/62655C04B2235/3843
Inventor 陈达邵帅斌练美玲
Owner 航大绿翼(天津)科技有限公司