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Synthesis method of polyglycolide, polyglycolide, application of polyglycolide and synthesis device

A synthesis method and technology of polyglycolide, applied in the application of polyglycolide and synthesis equipment, polyglycolide, the field of synthesis of polyglycolide, can solve the problems of uncontrollable reaction and many side reactions, and achieve The effect of stable product quality, controllable process and simple operation

Pending Publication Date: 2021-11-23
HANGZHOU REJOIN MASTIN MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] ①Many side effects;
[0005] ② uncontrollable reaction

Method used

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  • Synthesis method of polyglycolide, polyglycolide, application of polyglycolide and synthesis device
  • Synthesis method of polyglycolide, polyglycolide, application of polyglycolide and synthesis device
  • Synthesis method of polyglycolide, polyglycolide, application of polyglycolide and synthesis device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The present embodiment provides a kind of synthesis device of polyglycolide, such as figure 1 As shown, the polyglycolide synthesis device provided in this embodiment includes a melting bottle 1 and a polymerization bottle 2 , and the melting bottle 1 and the polymerization bottle 2 are communicated through a conduit 13 . The outlet of the melting bottle 1 is provided with a conduit 13, and the conduit 13 is connected with a vacuum device. The melting bottle 1 and the polymerization bottle 2 are independently provided with heating devices. A stirring paddle 11 is arranged inside the melting bottle 1 . The melting bottle 1 and the polymerization bottle 2 are provided with feeding ports. The melting bottle 1 is provided with a discharge port 12 . The discharge port 12 of the melting bottle communicates with the feed port 21 of the polymerization bottle through a connecting pipe 3 . The polymerization bottle 2 is provided with a positive and negative pressure display d...

Embodiment 2

[0085] This example provides a kind of polyglycolide, which is synthesized using the synthesis device provided in Example 1. Take 200g of refined glycolide, 0.1g of catalyst stannous octoate, and 0.2mL of n-dodecyl alcohol in a melting bottle, seal and vacuumize the synthesis device, pass nitrogen replacement 3 times, and protect the whole reaction process with nitrogen atmosphere. After the melting at 130°C is complete, the melt is transferred to the polymerization bottle through the connecting pipe, and the temperature in the polymerization bottle is set to 170°C in advance, and the reaction is carried out for 48 hours. After the reaction, freeze the polymerization bottle with liquid nitrogen, take out the finished product, crush it with a crusher, dry it, and wait for detection.

Embodiment 3

[0087] This example provides a kind of polyglycolide. The difference from Example 2 is that the initiator is n-stearyl alcohol 0.2g, the melting temperature is 140°C, the polymerization temperature is 160°C, and the reaction is 60 hours. The rest of the steps are the same as those in the implementation Example 2 is the same and will not be repeated here.

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Abstract

The invention provides a synthesis method of polyglycolide, polyglycolide, application of polyglycolide and a synthesis device, and particularly relates to the technical field of polymer synthesis. The synthesis method of the polyglycolide comprises the following steps: mixing glycolide, a catalyst and an initiator, melting, and then carrying out transfer polymerization to obtain the polyglycolide, the melting temperature being 90 to 150 DEG C; the polymerization temperature being 150 to 200 DEG C. The invention also provides a synthesis device of polyglycolide. The synthesis device comprises a melting bottle and a polymerization bottle which are communicated with each other, wherein the melting bottle is further connected with a vacuumizing device, and a stirring paddle is further arranged in the melting container. According to the synthesis method of the polyglycolide, provided by the invention, ester exchange reaction in molecules and ester exchange reaction among molecules are reduced by adopting different temperatures, and side reactions such as degradation are reduced at the same time, so that forward proceeding of the reaction is facilitated, the molecular weight of the polyglycolide is increased, the molecular weight of the obtained polyglycolide is 30,000-500,000, meanwhile, the mechanical strength of the polyglycolide is improved, and the mechanical property is superior to that of the traditional plastic.

Description

technical field [0001] The invention relates to the technical field of polymer synthesis, in particular to a synthesis method of polyglycolide, polyglycolide, the application of polyglycolide and a synthesis device. Background technique [0002] With the serious situation of petroleum-based plastic pollution, plastic restriction has become a global consensus. Cyclic polyesters such as polylactic acid and polyglycolide, as typical degradable polyesters, have received extensive attention from the market. Due to its excellent physical properties, polyglycolide has been applied in medical fields such as surgical sutures, artificial skin and blood vessels, bone fixation and repair, controlled release of drugs, and tissue engineering scaffolds. In addition, in the fields of unconventional oil and gas exploitation such as shale oil and shale gas, degradable bridge plugs and temporary plugging agents prepared from polyglycolide have good mechanical properties and rapid degradation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/06C08G63/78A61K47/34A61L17/00A61L27/18A61L27/50
CPCC08G63/06C08G63/785A61L17/00A61L27/18A61L27/50A61K47/34C08L67/04
Inventor 吴姗姗吴侃李若云李凌晨蒋冠森
Owner HANGZHOU REJOIN MASTIN MEDICAL INSTR CO LTD
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