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Pharmaceutical composition and health food

A technology for health food and composition, applied in the field of pharmaceutical composition and health food, can solve problems such as no visible results, and achieve the effects of improving cognitive function and spatial perception ability, inhibiting accumulation, and inhibiting acetylcholinesterase

Pending Publication Date: 2021-12-03
人类科学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, until now, the development of therapeutic agents has been actively carried out worldwide, and Korea is also conducting research on natural medicines, synthetic medicines, stem cell therapeutics, and peptide medicines, but there are no visible results so far.

Method used

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  • Pharmaceutical composition and health food
  • Pharmaceutical composition and health food
  • Pharmaceutical composition and health food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1. The preparation of the extract of steamed and exposed ginseng fruit using four-year-old ginseng.

[0070] The steamed ginseng fruit extract was prepared by using picked ginseng fruit by the following method.

[0071] First, ginseng fruits that were about to mature were picked from 4-year-old ginseng in late May 2018 (Gyeonggi-do, Korea), washed with clean water, and then dried with a hot air dryer (JW-500ED, Jinwoo Electronic Co., Korea) ) was dried at a temperature of 50° C. for 15 hours. Steam the dried ginseng fruit at 95°C for 5 hours, then dry at 50°C for 1 hour, and repeat this steaming and exposure process 4 to 7 times to obtain four-steamed and four-exposure or seven-steamed and seven-exposed ginseng fruits. Mix the obtained four-steamed-four-exposed and seven-steamed-seven-exposed ginseng fruits in a weight ratio of 1:1, add 30 times the volume of distilled water, and conduct hot water extraction at a temperature of 95°C for 24 hours to obtain ste...

Embodiment 2

[0073] Example 2. Preparation of steamed and exposed ginseng fruit extract using three-year-old ginseng.

[0074] Except for using 3-year-old ginseng instead of 4-year-old ginseng, the hot water extract and alcohol extract of steamed ginseng fruit were prepared from ginseng with 3-year-old root in the same method and conditions as in Example 1 above.

Embodiment 3

[0075] Example 3. Preparation of fermented product using steamed and exposed ginseng fruit extract of four-year-old ginseng

[0076] The above-mentioned steamed ginseng fruit extract prepared from four-year-old ginseng was inoculated with Lactobacillus plantarum (KCTC14392BP) strain to prepare a fermented product.

[0077] Wherein, the inventor of the present invention deposited the above-mentioned Lactobacillus plantarum (Lactobacillus plantarum) at the Korean Type Culture Collection (KCTC) (address: Jeollabuk-do, South Korea) on September 5, 2016, and its preservation number is KCTC21084, and, On November 30, 2020, the above strain was requested to be converted into a patent deposit under the Budapest Treaty (Budapest Treaty), which was assigned the deposit number KCTC14392BP (the depository institution is still the Korean Type Culture Collection (KCTC), and its address is South Korea. Luobei Road).

[0078] Specifically, after all the hot water extract and alcohol extract ...

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PUM

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Abstract

The present invention relates to a pharmaceutical composition for preventing or treating degenerative brain diseases comprising a fermented steam-dried ginseng berry. More specifically, the fermented steam-dried ginseng berry provides a high content of total ginsenoside and polyphenol and antioxidant activity, inhibits acetylcholinesterase, improves a cognitive function and a spatial perception ability in an animal model of dementia, recovers expression of acetylcholine in brain tissues of the animal model of dementia, inhibits amyloid-beta accumulation, suppresses brain damage in the animal model of dementia, and promotes expression of brain damage-related genes in neuronal cell lines, and thus, the fermented steam-dried ginseng berry can be advantageously used for the treatment of degenerative brain diseases, improvement of cognitive function, and brain protection.

Description

technical field [0001] The present invention relates to a pharmaceutical composition and health food for preventing or treating neurodegenerative diseases, which contain fermented product of steamed ginseng fruit as an active ingredient. Background technique [0002] Ginseng (Panax ginseng C.A.meyer) is a plant of the genus Panax in the Araliaceae family. It has been used as a crude drug for preventing diseases and prolonging life in Korea, China and Japan more than 2,000 years ago. The efficacy and effects of ginseng have been known so far to have the effect on the central nervous system, anti-carcinogenic effect, anti-cancer activity, immune function regulation effect, anti-diabetic effect, liver hyperfunction effect, improvement of cardiovascular disorders, anti-arteriosclerosis effect, blood pressure regulation effects, menopausal disorder improvement, osteoporosis improvement effect, anti-stress activity, anti-fatigue effect, antioxidant activity, anti-aging activity, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P25/00A61P25/28A61P25/16A61P25/14A61P9/10A23L33/00A61K131/00
CPCA61K36/258A61P25/00A61P25/28A61P25/16A61P25/14A61P9/10A23L33/00A61K2236/19A23V2002/00A23V2200/322A61K35/747A61K35/742A23L33/105A23L29/065A23V2250/2124A61K2236/33A61K2236/51
Inventor 朱成洙张秀吉
Owner 人类科学有限公司
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