Preparation method of sodium isethionate

A technology of sodium isethionate and ethanesulfonic acid, applied in the preparation of sulfonate, organic chemistry, etc., can solve the problems of increased workload, high energy consumption, cumbersome steps, etc., and achieve the effect of improving quality and application range

Active Publication Date: 2021-12-17
WANHUA CHEM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patent application CN102050764A provides a method for crystallizing and purifying sodium isethionate using a multi-effect evaporator, which can reduce the impurity ethylene glycol to 0.1 wt%, but this method will cause waste of materials and excessive energy consumption. The cumbersome steps increase a lot of workload

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Add 581.67g of choline chloride to the beaker, then add 1000g of pentafluoroethanesulfonic acid dropwise to the beaker, keep stirring during the dropwise addition to avoid local overheating, and stir at 20-50°C until completely dissolved to obtain the formula Choline Chloride-Pentafluoroethanesulfonic Acid Deep Eutectic Solvent.

[0036] Introduce 62.5 g of mixed inhibitors of sulfur dioxide and sulfur trioxide (mass ratio: 1:1) into 500.0 g of choline chloride-perfluoroethanesulfonic acid deep eutectic solvent, heat up to 150 ° C, press to 4 MPa, and stir 2h, to ensure that the solvent is fully absorbed and passivated.

[0037] Configure 1000g sodium bisulfite solution (12wt%) with passivation solvent and join in the reactor, temperature control is at 45 ℃, feed ethylene oxide 60.9g with the flow velocity of 15g / min in the reactor behind, during the reaction Regulate the reaction pressure at 2 bar, and time the reaction for 25 minutes after passing through the ethylen...

Embodiment 2

[0039]Add 788.16g of choline chloride to the beaker, then add 1000g of trifluoroethanesulfonic acid dropwise to the beaker, keep stirring during the dropwise addition to avoid local overheating, stir at 20-50°C until completely dissolved, and obtain the formula Choline chloride-trifluoroethanesulfonic acid deep eutectic solvent.

[0040] Pass into 500.0g of choline chloride-trifluoroethanesulfonic acid deep eutectic solvent 41.67g of mixed inhibitor of sulfur dioxide and sulfur trioxide (mass ratio is 1:0.5), heat up to 100°C, press to 1MPa, Stir for 0.5h to ensure that the solvent is fully absorbed and passivated.

[0041] Configure 1000g sodium bisulfite solution (5wt%) with passivation solvent and join in the reactor, temperature control is at 25 ℃, feed ethylene oxide 22.2g with the flow rate of 5.0g / min in the reactor behind, the reaction process Regulate the reaction pressure at 1 bar, and time the reaction for 5 minutes after passing through the ethylene oxide. After t...

Embodiment 3

[0043] Add 498.57g of choline chloride to the beaker, then dropwise add 1000g of pentafluoroethanesulfonic acid into the beaker, keep stirring during the dropwise addition to avoid local overheating, stir at 20-50°C until completely dissolved, and obtain the formula Choline Chloride-Pentafluoroethanesulfonic Acid Deep Eutectic Solvent.

[0044] Introduce 38.46 g of mixed inhibitors of sulfur dioxide and sulfur trioxide (mass ratio: 1:0.8) into 500.0 g of choline chloride-perfluoroethanesulfonic acid deep eutectic solvent, raise the temperature to 200 ° C, and press to 8.0 MPa, Stir for 1.0h to ensure that the solvent is fully absorbed and passivated.

[0045] Configure 1000g of sodium bisulfite solution (10wt%) with a passivation solvent and add it to the reactor, control the temperature at 80°C, then feed 59.25g of ethylene oxide into the reactor at a flow rate of 10.0g / min, and the reaction process Regulate the reaction pressure at 4.0bar, and time the reaction for 60 minut...

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PUM

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Abstract

The invention discloses a preparation method of sodium isethionate, which comprises the following steps of: introducing a novel deep-eutectic solvent which has good dissolvability to raw materials sodium hydrogen sulfite and ethylene oxide but has no dissolvability to products; and passivating the deep-eutectic solvent by using an inhibitor, dissolving sodium hydrogen sulfite in the passivated deep-eutectic solvent, introducing ethylene oxide into a reaction solution according to a ratio, and carrying out an addition reaction on sodium hydrogen sulfite and ethylene oxide to obtain sodium isethionate. As the solvent cannot dissolve sodium isethionate, the sodium isethionate is continuously separated out in a solid form along with the reaction without influencing the reuse of the reaction mother liquor. According to the method, the problem of accumulation of impurity ethylene glycol in a traditional ethylene oxide method is solved, and solid sodium isethionate with extremely high purity can be directly obtained.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a preparation method of sodium isethionate, a taurine intermediate. Background technique [0002] Sodium isethionate, also known as sodium 2-hydroxyethylsulfonate, is the main raw material for the production of taurine and sodium cocoyl isethionate, and is widely used in electroplating, detergent and other industries . It can be used as detergent for woolen products, intermediates of household chemical products (such as shampoo, high-grade soap, etc.), pharmaceutical raw materials and fine chemical products. [0003] At present, sodium isethionate is mainly used in the synthesis of taurine, and the specific steps are to utilize the ethylene oxide method: 1. sodium bisulfite solution and ethylene oxide carry out addition reaction to obtain sodium isethionate; 2. Ammonolysis of sodium isethionate solution and liquid ammonia produces sodium taurine; 3. Taurine is ob...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/08C07C303/32
CPCC07C303/32C07C309/08
Inventor 蔺海政桂振友郭斌孔令晓丰茂英付广权陈来中张永振
Owner WANHUA CHEM GRP CO LTD
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