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Metal organic framework material for purifying dendrobium officinale polysaccharide compound and purification method

A metal-organic framework and Dendrobium officinale polysaccharide technology, applied in chemical instruments and methods, other chemical processes, etc., to achieve good adsorption and desorption performance

Active Publication Date: 2021-12-21
梅州绿盛林业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]At present, most of the extraction methods of Dendrobium officinale are water extraction and alcohol precipitation, or the introduction of enzymes, ultrasonic waves and other auxiliary treatments during water extraction, and the purification methods usually use anion exchange columns Chromatography, there is still a lack of methods for enriching and separating polysaccharides from Dendrobium candidum and separating and purifying its active ingredients in the art

Method used

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  • Metal organic framework material for purifying dendrobium officinale polysaccharide compound and purification method
  • Metal organic framework material for purifying dendrobium officinale polysaccharide compound and purification method
  • Metal organic framework material for purifying dendrobium officinale polysaccharide compound and purification method

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Experimental program
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Effect test

Embodiment 1

[0043] The extraction of embodiment 1-Dendrobium officinale polysaccharide

[0044] 1. Experimental materials

[0045] The original medicinal material of Dendrobium candidum, remove impurities, cut the medicinal material into small pieces, dry at 50°C, powder, pass through a No. 3 sieve, and set aside.

[0046] UV1780 ultraviolet-visible spectrophotometer (Shimadzu, Japan); SIMF140AY65-PC ice machine (Matsushita Electric Industrial Co., Ltd., Japan); Merck Millipore Direct-Q, 3, 5, 8, pure water / ultrapure water All-in-one machine (Germany, Merck Group); HWS-28 electric heating constant temperature water bath (Shanghai Qixin Scientific Instrument Co., Ltd.); KQ-500DA CNC ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); D-glucose anhydrous standard (National Institute for Food and Drug Control, batch number: 110833-201506); concentrated sulfuric acid (Sinopharm Chemical Reagent Co., Ltd., batch number: 20180227); phenol (Sinopharm Chemical Reagent Co., Ltd., batch ...

Embodiment 2

[0072] Preparation and characterization analysis of embodiment 2-MIL-101 (Cr)

[0073] MIL-101(Cr) was synthesized by solvothermal method. The specific process was as follows: 30mL deionized water, 1.101g terephthalic acid, 2.699g chromium nitrate nonahydrate (Cr(NO) 3 9H 2 O) and 100 μL of hydrofluoric acid, magnetically stirred for 30 minutes, heated from room temperature to 220° C. and kept for 8 hours, cooled naturally, filtered with suction, purified, kept in an oven at 150° C. overnight, and set aside.

[0074] 1. Powder X-ray Diffraction (PXRD)

[0075] The powder X-ray diffraction (PXRD) method was used to characterize the phase crystallinity and purity of MOFs samples, and to verify whether the crystal structure of MOFs samples changed during the experiment. Adopt the D / MAX2500 type X. ray diffractometer (XRD) instrument that Japan Rigaku company produces, use Cu target ray Ka ray in the measurement process, wavelength is selected as the radiation source of A=0.1540...

Embodiment 3

[0086] Embodiment 3-[Zn(nicotinate) 2 ] n The preparation and characterization analysis of

[0087] According to the following steps to prepare [Zn(nicotinate) 2 ] n : Weigh zinc sulfate heptahydrate (ZnSO 4 ·7H 2 O) 2.336g was dissolved in 15mL distilled water, ultrasonicated until ZnSO 4 ·7H 2 O is completely dissolved. Weigh 1.00g of nicotinic acid into a beaker, add 5mL of DMF and 10mL of absolute ethanol, stir magnetically for 30min, then mix the two solutions, stir magnetically until evenly mixed, then transfer to a reaction kettle, and place in a 120°C Keep it under ambient conditions for 10 h, and cool it down to room temperature naturally to obtain a suspension with white precipitate. The product is filtered, washed with distilled water and hot ethanol several times and purified, then dried overnight at 150°C to obtain a white solid powder.

[0088] [Zn(nicotinate) 2 ] n The characterization analysis method is identical with above embodiment 2. The result i...

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Abstract

The invention provides a metal organic framework material for purifying a dendrobium officinale polysaccharide compound. The metal organic framework material is MIL-101 (Cr) prepared from chromium nitrate nonahydrate, deionized water, terephthalic acid and hydrofluoric acid through a solvothermal method. The invention also provides a method for purifying a dendrobium officinale polysaccharide compound. The method comprises the step of purifying a dendrobium officinale polysaccharide crude extract by using the metal organic framework material disclosed by the invention. The invention also provides application of the metal organic framework material in separation and purification of dendrobium officinale polysaccharide compounds. Compared with the prior art, the metal organic framework material disclosed by the invention has good adsorption and desorption performance on the dendrobium officinale polysaccharide, and is suitable for enriching, separating and purifying the dendrobium officinale polysaccharide.

Description

technical field [0001] The invention belongs to the field of organic chemistry, and in particular relates to a metal-organic framework material used for purifying polysaccharide compounds of Dendrobium officinale and a method for purifying polysaccharide compounds of Dendrobium officinale. Background technique [0002] There are many kinds of natural products, and their active ingredients are complex and low in content, which are difficult to enrich. How to purify and separate active ingredients from complex natural products is an important issue to speed up the application process of natural products. Using traditional separation methods, such as macroporous resins, silica gel column chromatography, etc., although these methods are simple in process, they consume a large amount of solvent, cause serious pollution, time-consuming, energy-consuming, and high economic costs, and are difficult to achieve for some components with similar structures and properties. effective sepa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00B01J20/22
CPCC08G83/008B01J20/226
Inventor 李远平
Owner 梅州绿盛林业科技有限公司