Artificial bone material without loss of elastic modulus as well as preparation method and application of artificial bone material

A technology of elastic modulus and artificial bone, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of clinical application and low elastic modulus, achieve strong industrial application potential, convenient operation, and avoid bone healing slow effect

Active Publication Date: 2021-12-21
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PEKK porous scaffolds are faced with the embarrassing situation that clinical application cannot be realized because the elastic modulus is lower than that of human bones.

Method used

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  • Artificial bone material without loss of elastic modulus as well as preparation method and application of artificial bone material
  • Artificial bone material without loss of elastic modulus as well as preparation method and application of artificial bone material
  • Artificial bone material without loss of elastic modulus as well as preparation method and application of artificial bone material

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preparation example Construction

[0033] The invention discloses a preparation method of an artificial bone material with no loss in elastic modulus, the steps are as follows:

[0034] a. Preparation of porogen: Use a pulverizer to pulverize the large-sized porogen, and use screens of different sizes to control the particle size of the porogen to 50 μm-200 μm;

[0035] b. Sulfonation treatment: Use 200-mesh, 400-mesh, and 600-mesh sandpaper to smooth the surface of the polyetheretherketone sample, and ultrasonically ultrasonicate the sample in ethanol, acetone, and deionized water for 15 minutes, and then immerse the naturally dried sample in a mass Soak in concentrated sulfuric acid with a fraction of 90%-98% for 30-180s;

[0036] c. Cold pressing: at room temperature, apply an external pressure of 2-6 MPa to the surface of the sulfonated polyether ether ketone material, so that the porogen spread under the material is embedded on the surface;

[0037] d. Leaching: Place the sulfonated sample in deionized wa...

Embodiment 1

[0040] Embodiment 1 A kind of artificial bone material without loss of elastic modulus and its preparation method

[0041] 1) Preparation of pure PEKK sample:

[0042] Use 200-mesh, 400-mesh, and 600-mesh sandpaper in turn to polish the surface of the polyether ketone ketone sample, and ultrasonically clean the sample in ethanol, acetone, and deionized water for 15 minutes, and then dry it naturally;

[0043] from figure 1 It can be seen from the scanning electron microscope image of the surface of the pure PEKK sample after polishing that the surface of the pure PEKK sample is smooth and flat, and no pore structure is observed.

[0044] 2) Preparation of sulfonated SPEKK samples:

[0045] Use 200-mesh, 400-mesh, 600-mesh sandpaper in turn to smooth the surface of the polyether ketone ketone sample, ultrasonicate the sample in ethanol, acetone, and deionized water for 15 minutes, and then immerse the naturally dried sample in a mass fraction of 90%-98 % concentrated sulfuri...

Embodiment 2

[0059] Embodiment 2 A kind of artificial bone material without loss of elastic modulus and its preparation method

[0060] 1) Preparation of a porous polyether ketone ketone material with no loss in elastic modulus:

[0061] a. Preparation of porogen: Use a pulverizer to pulverize the large-sized porogen sodium chloride, and use screens of different sizes to sieve out sodium chloride with a porogen size of 10 μm-50 μm.

[0062] b. Sulfonation treatment: use 200-mesh, 400-mesh, and 600-mesh sandpaper to smooth the surface of the polyetheretherketone sample, and ultrasonically ultrasonicate the sample in ethanol, acetone, and deionized water for 15 minutes, and then immerse the naturally dried sample in a mass Soak in concentrated sulfuric acid with a fraction of 90%-98% for 120s;

[0063] c. Cold pressing: at room temperature, an external pressure of 4 MPa is applied to the surface of the sulfonated polyetheretherketone material, so that the porogen spread under the material i...

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Abstract

The invention belongs to the technical field of biomedical polymer materials, and discloses an artificial bone material without loss of elastic modulus as well as a preparation method and application of the artificial bone material. According to the preparation method, sulfonation treatment is combined with a cold pressing technology, so that a cross-scale porous structure is constructed on the surface of polyether ketone ketone, and the modified polyether ketone ketone material comprising a small-pore structure with the pore diameter range of 0.5-5 microns and a large-pore structure with the pore diameter range of 50-200 microns is obtained. The material not only can effectively maintain the elastic modulus matched with the human skeleton, is beneficial to long-term stability after being implanted as an artificial bone material, avoids the problems of slow bone healing, osteoporosis and the like caused by a stress shielding effect, but also can improve the form of an implant through a cross-scale porous structure, and a biological anchoring effect is provided for inward growth of tissues.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and in particular relates to an artificial bone material with no loss in elastic modulus, a preparation method and application thereof. Background technique [0002] In order to manufacture orthopedic implants that can mimic the complex structure of bone, additive manufacturing technology is attracting more and more attention in the field of implant manufacturing. Metal materials represented by pure titanium and titanium alloys have become widely used 3D printing materials in clinical and experimental research due to their excellent biocompatibility. However, due to the high elastic modulus of metal implants, it will inevitably lead to the generation of stress shielding effect. [0003] The stress shielding effect means that when two materials with a large difference in elastic modulus are used together, the material with a larger elastic modulus bears greater stress. There...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26C08J7/14C08J7/12C08L61/16A61L27/18A61L27/50A61L27/56
CPCC08J9/26C08J7/14C08J7/12A61L27/18A61L27/56A61L27/50C08J2361/16A61L2430/02C08L61/16
Inventor 俞麟陈志勇丁建东
Owner FUDAN UNIV
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