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Method for preparing anticoagulant coating and medical implant

An anticoagulant and implant technology, applied in the field of medical devices, can solve the problems of poor controllability, complicated operation, poor coating durability, etc., and achieve the effect of good durability and simple operation

Pending Publication Date: 2021-12-21
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the methods for modifying the anticoagulant properties of metal materials mainly include electrochemical treatment, micro-arc oxidation, chemical conversion, ion implantation, laser surface melting, surface nanocrystallization and other methods. Most of these treatment methods have complex operations, Disadvantages such as poor controllability and poor coating durability

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  • Method for preparing anticoagulant coating and medical implant

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Effect test

Embodiment 1

[0045] In this embodiment, the substrate is a nickel-titanium alloy sheet of 5 cm×5 cm×0.6 mm.

[0046] The method for forming the anticoagulant coating on the surface of the substrate comprises the following steps:

[0047] First, the substrate was ultrasonically cleaned in ultrapure water for 10 minutes, and then taken out and dried.

[0048] Next, the substrate was immersed in a 5% 3-mercaptopropyltriethoxysilane solution in isopropanol to react for 2 hours, taken out for cleaning, and dried.

[0049] Next, immerse the substrate with mercapto groups introduced into its surface in an oxidative solution for oxidation reaction for 1 h, so as to introduce sulfonic acid groups on the surface of the substrate, take it out and wash it with ultrapure water. The oxidizing solution is formed by mixing methanol, 30% hydrogen peroxide aqueous solution and concentrated sulfuric acid, wherein the volume fraction of methanol is 19.95%, the volume fraction of hydrogen peroxide solution is...

Embodiment 2

[0054] In this embodiment, the substrate is a stainless steel sheet of 8 cm×8 cm×0.5 mm.

[0055] The method for forming the anticoagulant coating on the surface of the substrate comprises the following steps:

[0056] First, the substrate was ultrasonically cleaned in ultrapure water for 10 minutes, and then taken out and dried.

[0057] Next, the substrate was immersed in a methanol solution of 1% 3-mercaptopropyltrimethoxysilane to react for 3 hours, taken out, cleaned and dried.

[0058] Next, immerse the substrate with mercapto groups introduced into its surface in an oxidative solution for oxidation reaction for 30 minutes to introduce sulfonic acid groups on the surface of the substrate, take it out and wash it with ultrapure water. The oxidizing solution is formed by mixing methanol, 30% hydrogen peroxide aqueous solution and concentrated sulfuric acid, wherein the volume fraction of methanol is 50%, the volume fraction of hydrogen peroxide solution is 49.95%, and the...

Embodiment 3

[0063] In this embodiment, the substrate is a cobalt-chromium alloy sheet of 6 cm×6 cm×0.6 mm.

[0064] The method for forming the anticoagulant coating on the surface of the substrate comprises the following steps:

[0065] First, the substrate was ultrasonically cleaned in ultrapure water for 10 minutes, and then taken out and dried.

[0066] Next, the substrate was immersed in an ethanol solution with a mass fraction of 10% of 3-mercaptopropyltriethoxysilane to react for 1.5 hours, taken out, cleaned and dried.

[0067] Next, immerse the substrate with mercapto groups introduced into its surface in an oxidative solution for oxidation reaction for 1 h, so as to introduce sulfonic acid groups on the surface of the substrate, take it out and wash it with ultrapure water. The oxidizing solution is formed by mixing methanol, 30% hydrogen peroxide aqueous solution and concentrated sulfuric acid, wherein the volume fraction of methanol is 49.99%, the volume fraction of hydrogen p...

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Abstract

The invention relates to a method for preparing an anticoagulant coating and a medical implant, and in the method for preparing the anticoagulant coating, a base material is directly soaked in reaction solutions of all steps for corresponding reaction. The method for preparing the anticoagulant coating is easy to operate and high in controllability, complex equipment and operation are not needed, and a prepared anticoagulant coating has good durability.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a method for preparing an anticoagulant coating and a medical implant. Background technique [0002] Metal materials are one of the earliest biomedical materials used by human beings. They have excellent properties such as high strength, fatigue resistance and easy processing. Therefore, metal materials occupy an important position in biomedical materials. For biomedical materials to stay in the physiological environment of the human body for a long time and perform their functions, the first condition is to have relatively stable chemical properties and certain biocompatibility such as blood compatibility. However, the surface of some metal materials used in contact with tissues or body fluids lacks effective anticoagulant properties, which easily leads to coagulation on the surface of metal materials, which in turn leads to a series of side effects such as thrombus. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C22/50C23C22/54C23C22/58A61L33/10A61L33/12A61L33/04
CPCC23C22/50C23C22/54C23C22/58A61L33/0011A61L33/0041A61L33/0076A61L33/08A61L33/04A61L33/128C23C2222/20A61L2300/21A61L2300/232A61L2300/252A61L2300/42A61L2400/18A61L2420/02A61L2420/06C08L5/10C08L89/00
Inventor 冯德军杨敬轩康亚红陆威姜洪焱罗七一
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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