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Application of root and bark extract of broussonetia papyrifera in preparation of skin anti-allergy and antipruritic medicine

A technology for constructing tree roots and extracts, which can be used in drug combinations, skin diseases, and vector-borne diseases, and can solve problems such as skin atrophy, secondary, and aggravated infections

Active Publication Date: 2021-12-28
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use of these drugs can cause serious side effects
For example, long-term topical use of glucocorticoids can lead to skin atrophy, secondary or aggravated infection

Method used

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  • Application of root and bark extract of broussonetia papyrifera in preparation of skin anti-allergy and antipruritic medicine
  • Application of root and bark extract of broussonetia papyrifera in preparation of skin anti-allergy and antipruritic medicine
  • Application of root and bark extract of broussonetia papyrifera in preparation of skin anti-allergy and antipruritic medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of the root bark and stem bark extract of embodiment 1

[0016] Weigh 50g of dried and pulverized root bark, add 95% ethanol according to the material-to-liquid ratio of 1:4, heat and reflux at 75°C for extraction, once for 1 hour, and extract 3 times in total; combine the extracts and filter to obtain the supernatant ①, carry out rotary evaporation to 1 / 10 of the volume of the supernatant ① to obtain a concentrated solution; then add twice the volume of distilled water to the concentrated solution for ultrasonication; after fully dispersed, perform centrifugation to obtain the supernatant ②, rotary evaporate to no alcohol smell , then add an equal volume of ethyl acetate for extraction, repeat 2-3 times; remove the lower layer extract, then use an equal volume of water-saturated n-butanol to extract, repeat 2-3 times, combine the upper layer extracts to obtain n-butanol extraction liquid. Finally, the n-butanol extract was concentrated to an extract sa...

Embodiment 2

[0018] The in vitro hyaluronidase experiment of the root bark extract of embodiment 2

[0019] Studies have shown that hyaluronidase is closely related to allergies, and it can enzymatically decompose hyaluronic acid in the body, turning it into a low-molecular-weight acidic stimulus, and inducing the body to produce sensitive symptoms. The present invention adopts hyaluronidase in vitro inhibition experiment to measure the inhibitory effect of BP-R-nBtOH on hyaluronidase activity. The experimental concentration is 0.5mg / mL~2.5mg / mL.

[0020] Required solution preparation:

[0021] BP-R-nBtOH solution: take the BP-R-nBtOH in Example 1 and prepare a solution with a concentration of 0.5 mg / mL-2.5 mg / mL with deionized water.

[0022] Acetic acid buffer solution: Measure 1.155mL of glacial acetic acid and dilute to 100mL, mix well, take 4.8mL of it as solution A; weigh 2.72g of sodium acetate crystals, add water to dissolve to 100mL and mix well, take 45.2mL of it as solution B;...

Embodiment 3

[0033] The preparation of embodiment 3 tree root bark, stem bark hydrogel

[0034] Weigh 1 g of Carbomer 940, sprinkle it in 100 mL of water to swell overnight, and adjust the pH of the gel to 6.5 with triethanolamine. Take 1 g of the dry powder of n-butanol extract from root bark or stem bark (see Example 1 for the preparation method), fully dissolve it with a small amount of deionized water, add it to the prepared gel matrix, stir evenly, and replenish the gel with water. Glue to 10g, and mix uniformly to obtain a 10% root bark hydrogel preparation or a 10% stem bark n-butanol extract hydrogel preparation.

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Abstract

The invention provides application of broussonetia papyrifera root and bark extracts in preparation of skin anti-allergy and itching-relieving medicines. The anti-allergy effects of broussonetia papyrifera root and bark n-butyl alcohol extracts with different concentrations are investigated through an in-vitro hyaluronidase inhibition experiment; the hydrogel preparation is prepared by taking the N-butanol extract of the root bark of the broussonetia papyrifera as a raw material medicine, and the curative effect of the hydrogel preparation on a mouse itching model is investigated. Research results show that the broussonetia papyrifera root bark n-butyl alcohol extracts with different concentrations have an obvious hyaluronidase inhibition effect, and have a good prevention and treatment effect on a 4-aminopyridine induced mouse skin itch model. As a traditional medicinal material, the root bark of broussonetia papyrifera is high in external use safety, is expected to become an effective active component of an anti-allergy and antipruritic product, and has a wide development prospect in an external antipruritic preparation.

Description

technical field [0001] The invention relates to the application of the root bark extract of mulberry tree in the preparation of antiallergic and antipruritic medicine for skin. Background technique [0002] Pruritus is an unpleasant somatic sensation that is a common accompaniment of many allergic diseases. In recent years, the incidence of skin allergies and itching has been on the rise, which is related to changes in climate and environment, the application of a large number of chemicals, mental stress, and changes in dietary structure. Itching can thicken the skin and turn into eczema. In severe cases, scratches and blood scabs may appear, which significantly affects the physical and mental health and quality of life of patients. On the other hand, the scratching behavior caused by pruritus will not only damage the patient's skin barrier, but also make the patient fall into a vicious circle of "itch-scratch-severe itching", resulting in increasing treatment costs. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K9/06A61P17/00A61P37/08A61P17/04A61K125/00A61K135/00
CPCA61K36/60A61K9/06A61P17/00A61P37/08A61P17/04Y02A50/30
Inventor 刘冰由天辉张敏君杨慧文向文静曾诚
Owner GUANGDONG PHARMA UNIV
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