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Usnea barbata extract, application thereof and skin external preparation containing same

A technology of skin external preparations and extracts, applied in the field of skin external preparations, to achieve the effect of strengthening the human epidermal barrier, reducing loss, and improving structure

Pending Publication Date: 2022-01-04
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The technical problem solved by the present invention is to address the lack of active substances that can be used to improve skin anti-aging ability, promote cell proliferation, enhance epidermal barrier or improve aging skin in the prior art. Its preparation method and application

Method used

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  • Usnea barbata extract, application thereof and skin external preparation containing same
  • Usnea barbata extract, application thereof and skin external preparation containing same
  • Usnea barbata extract, application thereof and skin external preparation containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The preparation of embodiment 1 Usnea tobea extract

[0079] (1) Mixing the dried Usnea barbata powder and distilled water to obtain a mixture; wherein the mass ratio of the dried Usnea barbata powder to the distilled water is 0.5:5.

[0080](2) Add 10 mM tetrasodium edetate to the mixture in step (1), adjust the pH value to 10.5-11, and heat at 55° C. for 2 hours to obtain the mixture;

[0081] (3) Centrifuge the mixture of step (2) at 4000 g for 10 min to remove solid matter to obtain a crude Usnea barbata extract solution; check the pH value, if it is not 6-6.5, adjust the pH value to 6-6.5; Then dilute the Usnea barbadensis crude extract solution;

[0082] Purify the diluted Usnea barbata crude extract solution, and filter continuously with a filter with decreasing porosity to clarify the Usnea barbata crude extract solution, and finally filter and sterilize the Usnea barbata crude extract solution with a porosity of 0.2 μm; For the dill extract, the pH value of t...

Embodiment 2

[0084] Embodiment 2 tests the content of each component in the Usnea tobeta extract

[0085] The specific method is as follows:

[0086] The total sugar content of the extracts was determined by a modification of the assay protocol described by Dubois et al. (M. Dubois et al. 1956. Anal. Chem. 28:350-356). The assay involves dissolving the raw material in concentrated sulfuric acid and reacting it with phenol to form dye complexes. The absorbance of the complex was read at 490 nm in a spectrophotometer. Sugar content was determined using a glucose standard curve.

[0087] The amino acid content of the extract was determined by the protocol published by Moore et al. (MOORE S et al. J Biol Chem. 1948 Oct; 176(1):367-88.), the free amino acid content of the extract was determined by using ninhydrin reagent to destroy amine Estimated by the formation of dye complexes after the base and carboxyl functional groups. The absorbance of the complex was read on a spectrophotometer at...

Embodiment 3

[0091] Embodiment 3 contains the lotion of Usnea barbadensis extract

[0092] According to the following components and dosage, the lotion is prepared, and the percentage refers to the weight percentage of each component in the lotion:

[0093] Glycerin 5%, polyols A 3-6%, betaine 1%, panthenol 0.5%, dipotassium glycyrrhizinate 0.05-0.1%, polyethylene glycol-32 0.5%, surfactant A 0.15-0.2%, 0.4-0.45% of preservative A, 0-0.15% of xanthan gum, 0.03% of perfume and the extract of Usnea barbata, the rest is deionized water, and the weight percentage sum of the above components is 100%.

[0094] Wherein, the percentage by weight of the Usnea barbadensis extract is 1%.

[0095] Polyols B are butanediol and 1,3-propanediol. Surfactant B is polyglyceryl-2 oleate and polyglyceryl-10 oleate. Preservatives B are propylparaben, methylparaben and phenoxyethanol. Acrylic resin Pemulen TR-2 is an acrylic (ester) / C10-30 alkanol acrylate crosspolymer. Xanthan gum is an extracellular mi...

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Abstract

The invention discloses an usnea barbata extract, application thereof and a skin external preparation containing the usnea barbata extract. The usnea barbata extract comprises saccharides, amino acids, phenolic compounds and small molecular weight RNA with the maximum length of 150 nucleotides; wherein the dry weight of the usnea barbata extract is 7-9g / kg; the concentration of the saccharides is 3-5g / L; the concentration of the amino acid is 100-300 mg / L; the concentration of the phenolic compounds is 400 to 600 mg / L; and the concentration of the small molecular weight RNA with the maximum length of 150 nucleotides is 10-30 mg / L. The usnea barbata extract disclosed by the invention is clear in action mechanism, safe and reliable, and has the effects of resisting aging, promoting cell proliferation, enhancing epidermal barrier and improving aged skin.

Description

technical field [0001] The present invention relates to a kind of Usnea barbata extract, its application and skin external preparation containing it. Background technique [0002] With the continuous development and maturity of the skin care product market, consumers are paying more and more attention to their own skin conditions. They hope to maintain a healthy and young skin condition through skin care products and see effective skin care effects. Therefore, the efficacy mechanism of active substances in skin care products The level of research needs to be improved, and the interpretation of the efficacy mechanism is getting more and more in-depth. It cannot be limited to simply describing the appearance, but needs to integrate biotechnology to deeply explain the change mechanism of the skin state. With the continuous development of cell biology technology, researchers have deepened their research on skin biology and discovered more targets and regulatory mechanisms relate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9733A61Q19/08A61K36/09A61P17/18
CPCA61K8/9733A61Q19/08A61K36/09A61P17/18A61K2800/805
Inventor 蒋丹丹李慧王风楼
Owner JALA GROUP CORPORATION
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