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Sterilization and antibacterial cooperative treatment method for medical instrument and intelligent medical instrument

A medical device and collaborative processing technology, which is applied in toilet sanitary equipment, water supply equipment, buildings, etc., can solve the problem of pH reduction, achieve the effect of inhibiting recurrence, excellent antibacterial effect, and good market promotion prospects

Active Publication Date: 2022-01-14
SHENZHEN WORLD SURGERY MEDICAL DEVICE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the existing surgical infection problem, provide a kind of medical equipment sterilization and antibacterial synergistic treatment method, by this method, antibacterial treatment is completed in the sterilization process, the sterilization procedure of medical equipment is hardly increased, only By changing the sterilization conditions, you can obtain intelligent medical devices, which not only meet the current sterile requirements of surgical tools, but also can automatically adjust the release speed of antibacterial components according to the human body environment during use, and truly realize the accelerated release of infected wounds , the excellent effect of slow release on normal wounds; more importantly, the volatile carboxylic acid produced at the same time as the antibacterial agent is released, resulting in a decrease in pH, making the wound environment closer to a slightly acidic environment that is conducive to promoting wound healing , which also has the unexpected effect of promoting wound healing

Method used

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  • Sterilization and antibacterial cooperative treatment method for medical instrument and intelligent medical instrument
  • Sterilization and antibacterial cooperative treatment method for medical instrument and intelligent medical instrument
  • Sterilization and antibacterial cooperative treatment method for medical instrument and intelligent medical instrument

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] A medical device sterilization and antibacterial co-processing method, comprising:

[0064] Step 1: prepare the ethyl acetate solution of acetic acid with a molar concentration of 0.5mol / L, and the ethyl acetate solution of triclosan with a molar concentration of 0.1mol / L;

[0065] Immerse the polyurethane sponge in the above-mentioned ethyl acetate solution of acetic acid for 5-20s to obtain a sponge with acetic acid / ethyl acetate solution;

[0066] DuPont Tyvek paper is used as a load carrier, immersed in triclosan-ethyl acetate solution for 5-20s, and dried for 12h-36h to obtain Tyvek paper with triclosan.

[0067] Step 2: Put the sponge with acetic acid / ethyl acetate solution and the polypropylene mesh strip in the same blister box, and the polypropylene mesh strip is attached to the inner wall of the container, and then soak and dry The dry Tyvek paper with triclosan is covered on the blister box and sealed to obtain the sample to be sterilized. Since the special ...

Embodiment 2

[0072]In this example, taking ultra-high molecular weight polyethylene suture thread as an example, the medical device sterilization and antibacterial synergistic treatment method is introduced. The ultra-high molecular weight polyethylene suture thread is a product produced by Dabo Medical Technology Co., Ltd., and the model is 2# Absorbable sutures. It should be noted that the method in the present invention is not limited to medical devices made of polyethylene, and other materials such as polypropylene, polyether ether ketone, polyurethane, polydioxanone, etc. At the same time, the method of the present invention is not limited to sutures, other types of medical devices such as antibacterial surgical tools, antibacterial suture tools, antibacterial dressings, antibacterial hernia patch, antibacterial meningeal patch, antibacterial tape thread anchor, antibacterial tape trip titanium The same applies to boards, etc.

[0073] Methods as below:

[0074] Step 1: Prepare the ...

Embodiment 3

[0085] In this example, the antibacterial effect of the ultra-high molecular weight polyethylene suture obtained in Example 2 under different pH conditions was studied.

[0086] Inhibition zone tests were carried out under different pH conditions, pH = 3, 6 and 9 respectively, using Staphylococcus aureus, two samples in each group, taking the average value, the antibacterial effects are shown in Figure 5 , Image 6 and Figure 7 , the antibacterial data are shown in Table 2.

[0087] Table 2 The antibacterial effect table of suture after 24h culture in different pH environments

[0088] group pH=3 pH=6 pH=9 1 1.1 1.5 4.0 2 1.2 1.5 4.2 Average diameter of inhibition zone / cm 1.15 1.5 4.1

[0089] from Figure 5 , Image 6 , Figure 7 As can be seen from Table 2, when the environmental pH value increases, reaching alkaline conditions can accelerate the hydrolysis of triclosan carboxylate esters and improve antibacterial performance...

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Abstract

The invention relates to a sterilization and antibacterial cooperative treatment method for a medical instrument and an intelligent medical instrument. The sterilization and antibacterial cooperative treatment method comprises the following steps: step 1, obtaining a carrier impregnated with triclosan and a carrier impregnated with volatile carboxylic acid; step 2, putting the carrier impregnated with the triclosan, the carrier impregnated with the volatile carboxylic acid and a to-be-treated medical instrument into a container to obtain a to-be-sterilized sample; step 3, putting the to-be-sterilized sample into sterilization equipment, and performing ethylene oxide sterilization to obtain a sterilized medical instrument; and step 4, performing ethylene oxide analysis on the sterilized medical instrument. According to the sterilization and antibacterial treatment method for the medical instrument, the formation of an antibacterial layer and sterilization treatment are combined, the problems that the triclosan is unevenly loaded and release cannot be controlled in vivo are solved, the antibacterial effect is achieved to the maximum extent and most effectively, the triclosan can be intelligently released according to the use environment requirement, besides, wound healing can be promoted, and the method has important practical significance for treating postoperative infection.

Description

technical field [0001] The invention relates to a medical device processing technology, in particular to a medical device sterilization and antibacterial collaborative processing method and an intelligent medical device. Background technique [0002] A large number of patients around the world undergo a large number of surgical operations every year. According to the data released by the National Bureau of Statistics, in 2019, the number of inpatient surgeries in medical and health institutions across the country reached more than 69 million. More than 27 million operations are performed in the United States every year, and the rate of postoperative surgical site infections (SSIs) reaches 2% to 3%. There are nearly 700,000 cases of SSIs each year. [0003] The occurrence of postoperative infection is related to the growth of bacteria in the postoperative site and the colonization of surgical implants or medical devices to form colonies. During the operation, bacteria in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/20A61L2/26A61L2/18A61L101/44A61L101/34
CPCA61L2/206A61L2/26A61L2/18A61L2202/24A61L2101/34Y02A50/30
Inventor 张雄曾达时瑞林意华兰林晖
Owner SHENZHEN WORLD SURGERY MEDICAL DEVICE TECH