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PDMS microneedle secondary mother board transfer process based on 3D printing technology

A 3D printing and microneedle technology, applied in 3D object support structures, manufacturing tools, additive processing, etc., can solve the problems of incompatible factory-scale preparation, inability to use large-scale, complex technical processes, etc., and achieve excellent replication performance , low cost, flexible mode effect

Pending Publication Date: 2022-01-14
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the traditional transdermal drug delivery method, the microneedle transdermal drug delivery system has a large drug load, can painlessly transport the drug to the subcutaneous layer through the stratum corneum of the skin, and can deliver the drug accurately and effectively, so that the drug can be maximized. Absorption; the system has the advantages of safety, painless, minimally invasive, drug sustained and controllable release, and convenient use. It has emerged as a new transdermal drug delivery system and has received extensive attention. , diabetes treatment, etc. have been widely used, and have broad market application prospects; there are various methods for microneedle preparation, and currently there are mainly microtemplate method, droplet generation air blowing method, electric stretching method, thermal stretching method , magnetorheological stretching lithography, 3D printing, etc., these processing methods can prepare silicon microneedles, metal microneedles and polymer microneedles, etc., with controllable aspect ratio, high sharpness, drug loading capacity Among them, the micro-template method is widely used due to its high accuracy, multi-function and repeatability of the template, but it has not been able to achieve low-cost mass production, so that it cannot be used on a large scale; its classic production process is The following three main steps: (1) use a strong material (metal or silicon) to prepare a microneedle positive mold by laser etching and ion etching; (2) make a negative mold (usually made of polydimethylsiloxane) through a positive mold (3) form the final microneedle structure in the female mold; the above-mentioned preparation methods require expensive equipment, complicated technical processes, and do not meet the requirements of large-scale preparation in factories, so in specific applications limited space in

Method used

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  • PDMS microneedle secondary mother board transfer process based on 3D printing technology
  • PDMS microneedle secondary mother board transfer process based on 3D printing technology
  • PDMS microneedle secondary mother board transfer process based on 3D printing technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Based on the 3D printed microneedle tip male mold 2, the microneedle female mold 3 was prepared using PDMS material;

[0049] Implement the first step: make a microneedle model with an aspect ratio of 4:1, a pitch of 1.5mm, and a needle height of 0.2-3mm on 3DMax software, and export it in STL format for printing;

[0050] Implement the second step: import the STL file into the light-curing 3D printer, and use the 3D printed light-curing resin for printing, with a slice thickness of 0.1mm;

[0051] Implement the third step: after the printing is completed, wash with 95%-100% absolute ethanol or acetone to wash off the excess resin solution on the template;

[0052] Carry out the fourth step: Put the cleaned microneedle tip mold into the UV lamp curing box for curing, but the curing time should not be too short to avoid insufficient strength of the resin microneedle tip template;

[0053] Implement the fifth step: fix the base plate of the resin microneedle t...

Embodiment 2

[0059] Example 2: Based on the 3D printed microneedle tip male mold 2, the microneedle female mold 3 was prepared using PDMS material;

[0060] According to Example 1, using PDMS material to prepare different microneedle female molds 3, the difference is that the PDMS solid-liquid weight is mixed uniformly according to different weights: 1. The PDMS solid-liquid weight is mixed uniformly according to 10:2.1; 2. The PDMS solid-liquid weight is uniformly mixed according to 10:2.1; The liquid weight is mixed evenly according to 10:2.2; 3. The PDMS solid-liquid weight is mixed evenly according to 10:2.3; 4. The PDMS solid-liquid weight is mixed evenly according to 10:2.4; 5. The PDMS solid-liquid weight is mixed evenly according to 10:2.5;

[0061] Use PDMS material to prepare different microneedle female molds 3, the difference is: 1. After the PDMS perfused microneedle mold is left to stand, put it into a vacuum drying oven for drying at 80°C for 2 hours; 2. PDMS perfusion After...

Embodiment 3

[0062] Example 3: Based on the 3D printed microneedle tip male mold 2, the microneedle female mold 3 was prepared using PDMS material;

[0063] According to Example 1, using PDMS material to prepare different microneedle female molds 3, the difference is: 1. Use 3D printed photocurable resin for printing, the thickness of the slice is 0.05mm, and when the thickness of the slice is 0.05mm, it is higher than when the thickness is 1mm The positive mold of the resin microneedle tip is smoother; 2. It is printed with 3D printed light-cured resin, and the thickness of the slice is 0.025mm. Figure 5 It can be seen that when printing with 3D printed light-curing resin, when the thickness of the slice is 0.025mm, it is smoother and more precise than the resin microneedle tip male mold with a thickness of 0.1mm and 0.05mm;

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Abstract

The invention discloses a PDMS microneedle secondary mother board transfer process based on a 3D printing technology, and provides a preparation method and application of the PDMS microneedle secondary mother board transfer process. A resin microneedle male mold printed by a photocuring printer is copied through the PDMS transfer process in a high-precision mode,the preparation process of a microneedle template is greatly simplified, and the PDMS microneedle secondary mother board transfer process has the advantages of being controllable in size, large in scale, high in precision, economical, efficient and the like. The resin microneedle tip template manufactured through the 3D printing technology is used as a PDMS material transfer female die, the equipment cost problem in the microneedle preparation process is greatly reduced, and the PDMS microneedle secondary mother board transfer process has the advantages of being economical, efficient, easy to operate, flexible in mode, personalized, high in precision and the like. According to the prepared PDMS microneedle female die, a PDMS material is adopted for die transfer, and besides low cost and simple operation, on one hand, the PDMS material has excellent replication performance, the replication ratio of a microneedle array can reach the maximum, and the distortion phenomenon is reduced to the maximum extent.

Description

technical field [0001] The invention relates to a microneedle mold for a 3D printer, specifically a PDMS microneedle secondary master plate transfer process based on 3D printing technology, and belongs to the technical field of biological materials. Background technique [0002] Due to the barrier function of the stratum corneum of the human skin, most drugs cannot directly and quickly enter the subcutaneous area to achieve an ideal therapeutic effect. Compared with the traditional transdermal drug delivery method, the microneedle transdermal drug delivery system has a large drug load, can painlessly transport the drug to the subcutaneous layer through the stratum corneum of the skin, and can deliver the drug accurately and effectively, so that the drug can be maximized. Absorption; the system has the advantages of safety, painless, minimally invasive, drug sustained and controllable release, and convenient use. It has emerged as a new transdermal drug delivery system and ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/124B29C64/307B29C64/35B33Y40/00B33Y40/20B33Y80/00B29C35/08
CPCB29C64/124B29C64/307B29C64/35B33Y40/00B33Y40/20B33Y80/00B29C35/0805B29C2035/0827
Inventor 范增杰张向丽
Owner LANZHOU UNIVERSITY