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Tissue-adhesive hydrogel and application thereof

A technology of hydrogel and precursor solution, which is applied in the field of medical materials, can solve the problems of mechanical strength, antibacterial property, hemostatic effect to be clarified and improved, poor tissue adhesion performance, long gel time, etc., and achieve excellent biological Compatibility, improved antibacterial performance, and excellent tissue adhesion

Active Publication Date: 2022-01-18
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although biocompatibility is good, its gel time is relatively long, and its adhesion to tissues is poor, only 10-30gfcm 2 (1 ~ 3KPa), the application is limited, and its mechanical strength, antibacterial property, and hemostatic effect have yet to be clarified and improved

Method used

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  • Tissue-adhesive hydrogel and application thereof
  • Tissue-adhesive hydrogel and application thereof
  • Tissue-adhesive hydrogel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1, the preparation of adhesive hydrogel of the present invention

[0076] 1. The lyophilized ADA-PBA was dissolved in 0.02% NaOH PBS solution containing 1% LAP at a mass volume ratio of 10%. Incubate at 50°C for 15 minutes to fully dissolve and set aside.

[0077] 2. The freeze-dried CMCS-MA-DD was dissolved in PBS solution with a mass volume ratio of 10%. Incubate at 50°C for 15 minutes to fully dissolve and set aside.

[0078] 3. Mix the solutions in step 1 and step 2 evenly at a volume ratio of 1:1, adjust the pH value of the system to between 7-8 with a certain amount of 2% NaOH PBS solution, and the gel will form within 5s to obtain a hydrogel Glue H (Non-P).

Embodiment 2

[0079] Embodiment 2, the preparation of adhesive hydrogel of the present invention

[0080] The gel H(Non-P) of Example 1 was irradiated with 405nm blue light for 60s, and the gel system was further cross-linked to form hydrogel H(P).

Embodiment 3

[0081] Embodiment 3, the preparation of adhesive hydrogel of the present invention

[0082] 1. The lyophilized ADA-PBA was dissolved in 0.02% NaOH PBS solution containing 1% LAP at a mass volume ratio of 10%. Incubate at 50°C for 15 minutes to fully dissolve and set aside.

[0083] 2. The freeze-dried CMCS-MA-DD was dissolved in PBS solution with a mass volume ratio of 10%. Incubate at 50°C for 15 minutes to fully dissolve and set aside.

[0084] 3. Prepare 400 μg / mL tannic acid PBS solution, which is ready for immediate use.

[0085] 4. Mix the solutions in step 1 and step 2 at a volume ratio of 1:1, then add a certain amount of the solution in step 3, so that the concentration of tannic acid in the final gel is 5 μg / mL, and mix well. Use a certain amount of 2% NaOH PBS solution to adjust the pH value of the system to 7-8, the gel will form within 5s, and irradiate with 405nm blue light for 60s, the gel system will be further cross-linked, and the hydrogel H(P+T) will be o...

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Abstract

The invention provides tissue-adhesive hydrogel. The tissue-adhesive hydrogel is formed by crosslinking modified carboxymethyl chitosan containing alkenyl and catechol groups, modified alginic acid containing aldehyde groups and dihydroxyboryl phenyl or salt thereof, a solvent and / or tannic acid. The hydrogel provided by the invention is good in mechanical property and biocompatibility, has excellent tissue adhesion, antibacterial property and hemostatic property, can be used for quickly closing wounds and realizing the effects of stopping bleeding, inhibiting bacteria and promoting wound healing as a medical tissue adhesive and wound dressing, and has a very good application prospect.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a tissue-adhesive hydrogel and its application. Background technique [0002] Acute trauma often occurs in military training and daily life. Uncontrollable bleeding and wound infection after tissue damage are the main causes of casualties. Therefore, it is very necessary to use first-aid supplies with the characteristics of fast sealing of wound surface, fast hemostasis, anti-infection and easy to use in first aid. At present, the gold standard for clinical wound closure is suture and anastomosis, but these methods will cause secondary tissue damage, wound infection, and are not suitable for emergency operations. Therefore, there is an urgent need to develop more rational approaches to acute wound management. [0003] With the development of biomaterials, many tissue adhesives are used for acute wound closure. Fibrin glue and cyanoacrylate glue are commonly used ti...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00A61L26/00C08J3/075C08J3/28C08L5/08C08L5/04C08K5/1545
CPCA61L24/0031A61L24/0015A61L24/08A61L26/0023A61L26/008A61L26/0066C08J3/075C08J3/28C08J2305/08C08J2305/04C08K5/1545A61L2400/04A61L2300/232A61L2300/404A61L2300/418C08L5/08C08L5/04
Inventor 解慧琪邹晨宇雷雄心
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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