Crude tea extract/chitosan oligosaccharide nanoparticle effervescent cream material, preparation method and application

A nanoparticle and extract technology, applied in applications, pharmaceutical formulations, food science, etc., can solve the problems of fast effervescent reaction rate, inability to maintain a mixed state, difficult to form a uniform dispersed self-assembly to create an environment, etc., to reduce Energy consumption, the effect of simplifying the production process

Active Publication Date: 2022-02-08
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the solubility of biological macromolecules represented by polysaccharides and proteins is different, and it is difficult to form a uniform dispersion system under the drive of effervescence to create an environment for the self-assembly between molecules only by changing the dispersion means; and the effervescent reaction rate is very fast, which cannot Maintain the mixed state for tens of minutes, which is the main obstacle for the direct application of effervescent technology to the preparation of nanomaterials

Method used

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  • Crude tea extract/chitosan oligosaccharide nanoparticle effervescent cream material, preparation method and application
  • Crude tea extract/chitosan oligosaccharide nanoparticle effervescent cream material, preparation method and application
  • Crude tea extract/chitosan oligosaccharide nanoparticle effervescent cream material, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A kind of preparation of the crude tea extract / chitooligosaccharide nanoparticle effervescent paste of allyl isothiocyanate (AITC), adopts the following steps:

[0052] S1: Take respectively 70 parts of crude tea extract rich in tea polysaccharide as wall material, 30 parts of chitosan oligosaccharide, 180 parts of citric acid and 280 parts of sodium bicarbonate solid as the acid and alkali in the effervescent agent and grind and grind to After there are no obvious large particles, sieve, the mesh should be ≥ 40 mesh, dry and store for later use;

[0053] S2: Put the crude tea extract, chitosan oligosaccharide, citric acid and sodium bicarbonate in the used S1 into the freeze dryer for 24 hours to dry. In order to ensure the stability of the paste during storage, the samples used should be as dry as possible;

[0054] S3: Mix PEG-600, which is liquid at normal temperature, and PEG-800, which is waxy solid at normal temperature, to adjust the appropriate carrier viscosit...

Embodiment 2

[0062] The preparation of a crude tea extract / chitooligosaccharide nanoparticle effervescent cream loaded with vitamin E (Vitamin, VE) adopts the following steps:

[0063] S1: Take respectively 80 parts of crude tea extract rich in tea polysaccharide as wall material, 20 parts of chitosan oligosaccharide, 180 parts of citric acid and 280 parts of sodium bicarbonate solid as acid and alkali in the effervescent agent and grind to After there are no obvious large particles, sieve, the mesh should be ≥ 40 mesh, dry and store for later use;

[0064] S2: Put the crude tea extract, chitosan oligosaccharide, citric acid and sodium bicarbonate in S1 into the freeze dryer for 48 hours to dry. In order to ensure the stability of the paste during storage, the samples used should be as dry as possible;

[0065] S3: Mix PEG-600, which is liquid at normal temperature, and PEG-800, which is waxy solid at normal temperature, to adjust the appropriate carrier viscosity and the amount of co-emul...

Embodiment 3

[0069] A kind of preparation of the crude tea extract / chitooligosaccharide nanoparticle effervescent paste of allyl isothiocyanate (AITC), adopts the following steps:

[0070] S1: Take 50 parts of crude tea extract rich in tea polysaccharide as wall material, 10 parts of chitosan oligosaccharide, 150 parts of tartaric acid as acid and alkali in effervescent agent, and 160 parts of sodium carbonate solid, and grind them until there is no obvious After the large particles are sieved, the mesh should be ≥ 40 mesh, dry and store for later use;

[0071] S2: Put the crude tea extract, chitosan oligosaccharide, tartaric acid and sodium carbonate used in S1 into a freeze dryer for 24 hours to dry. In order to ensure the stability of the paste during storage, the samples used should be as dry as possible;

[0072] S3: 150 parts of glycerin and 100 parts of Tween were mixed and prepared; the mixture was homogenized at 6000 rpm for 4 minutes to prepare an empty paste carrier;

[0073] S...

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Abstract

The invention relates to the technical field of active substance processing and delivery, in particular to a crude tea extract/chitosan oligosaccharide nanoparticle effervescent cream material, a preparation method and application. The crude tea extract/chitosan oligosaccharide nanoparticle effervescent cream is prepared from an effervescing agent, a plasticizer, a nonionic surfactant, a wall material and a core material by a specific preparation method. The crude tea extract/chitosan oligosaccharide nanoparticle effervescent cream and the preparation method are provided aiming at the defects of high energy consumption, long time, equipment requirement and organic solvent use in the field of nano material preparation, the technical requirements for simplicity, rapidness and low energy input are realized, the popularization and use of nano materials in actual production and daily life are promoted, and a new scheme is provided for nano delivery of hydrophobic substances.

Description

technical field [0001] The invention relates to the technical field of active substance processing and delivery, in particular to a crude tea extract / chitooligosaccharide nanoparticle effervescent cream material, a preparation method and application. Background technique [0002] Compared with general size, nanoscale substances have many advantages, such as larger specific surface area, higher loading capacity, better bioaccessibility, etc. In the fields of food, medicine, and biology, nanocomposites have been widely studied and applied in food preservation, active and drug delivery, and enzyme-loaded catalysis. [0003] The current preparation methods of nanomaterials (including nanoparticles, nanoliposomes and nanospinning, etc.) are mainly based on two types of methods: first, relying on the input of external mechanical energy, through high-speed stirring or the shearing effect brought by homogenization Promote the formation of nanocomposites. This method is mostly used ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/02C08L5/00C08L5/08C08L71/02C08K5/36C08K5/1545C08K5/13C08B37/00A23L33/105A23L33/125A23L2/395A61K47/46A61K47/36
CPCC08J9/02C08J9/0061C08J9/0033C08J9/0023C08B37/0003A23L33/105A23L33/125A23L2/395A61K47/46A61K47/36C08J2305/00C08J2405/08C08J2471/02A23V2002/00A23V2200/30A23V2200/328A23V2250/214A23V2250/282A23V2250/032A23V2250/1614A23V2250/1576A23V2250/712Y02A50/30
Inventor 孙逊董乾震李畅李钰金
Owner OCEAN UNIV OF CHINA
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