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Film coating composition for silicification-free rubber plug, coating liquid for silicification-free rubber plug, preparation method of coating liquid and method for preparing silicification-free rubber plug

A technology of composition and siliconized rubber, which is applied in the field of preparation of coating liquid for siliconized rubber plugs, preparation of siliconized rubber plugs, and coating liquids for siliconized rubber plugs, which can solve the problem of weak adhesion of film materials and problems with film coating Rubber stoppers are hard, difficult to recycle and reuse, etc., to achieve reliable biological safety and biological stability, avoid mutual diffusion and penetration, and protect drug stability.

Active Publication Date: 2022-02-11
CHINA PETROLEUM & CHEM CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example: the surface of the rubber stopper is fully covered or the neck is covered with a film, but the film-coated rubber stopper is mainly used for pharmaceutical packaging with a high pH, ​​and it is prone to weak adhesion of the film material, easy peeling off of the film material, poor elasticity of the film material, and Membrane rubber plugs are relatively hard, prone to problems such as poor self-sealing and poor acupuncture performance, and are also more expensive
[0006] For example, CN2768773Y discloses a non-siliconization medical rubber stopper, which is composed of a thin film on the top surface and peripheral wall of the crown of the rubber stopper In order to avoid the pollution caused by siliconization of the rubber stopper, but when the film of this rubber stopper is pierced by the needle, the liquid medicine will come into contact with the rubber stopper, and it can still pollute the liquid medicine
[0007] Improved technical scheme CN105907298A discloses a kind of graft type rubber plug spraying liquid, which adopts catalysts such as dibutyltin dilaurate and dibutyltin dilaurate, Harmful to the human body and the environment, and difficult to separate during the reaction
[0008] Improved technical scheme CN107629240A discloses a preparation process of a silicone-free rubber plug, which uses a homogeneous catalyst such as titanate, which is difficult to recycle and repeat after the reaction. It is easy to be deactivated by hydrolysis; in addition, it uses high temperature thermal curing to cure the coating, the curing cycle is longer, and the curing temperature is higher

Method used

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  • Film coating composition for silicification-free rubber plug, coating liquid for silicification-free rubber plug, preparation method of coating liquid and method for preparing silicification-free rubber plug
  • Film coating composition for silicification-free rubber plug, coating liquid for silicification-free rubber plug, preparation method of coating liquid and method for preparing silicification-free rubber plug
  • Film coating composition for silicification-free rubber plug, coating liquid for silicification-free rubber plug, preparation method of coating liquid and method for preparing silicification-free rubber plug

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Experimental program
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Embodiment approach

[0033] According to a preferred embodiment of the present invention, the silicon-aluminum molar ratio of the H-type β-molecular sieve catalyst is 20-60. In such an embodiment, the preparation of the coating composition for silicone-free rubber stoppers with the catalyst containing the silicon-aluminum molar ratio is more conducive to the preparation of rubber stoppers with a low surface friction coefficient.

[0034] Preferably, the end-blocked polydimethylsiloxane is selected from amino-blocked polydimethylsiloxane, hydroxyl-blocked polydimethylsiloxane, α-hydrogen-ω-hydroxyl-polydimethylsiloxane at least one of siloxane and alkoxy-terminated polydimethylsiloxane. In the end-capped polydimethylsiloxane of the present invention, the alkoxy group includes a straight-chain alkoxy group, a branched-chain alkoxy group or a cycloalkoxy group, and the total number of carbon atoms in the alkoxy group is 1 -20.

[0035] According to a preferred embodiment of the present invention, t...

specific Embodiment approach

[0058] According to a preferred embodiment of the present invention, the method further includes: before performing the thermal curing, first drying the sprayed rubber plug; preferably, the drying temperature is 100-160°C .

[0059] The thermal curing, for example, can be carried out at a constant temperature, such as curing at a temperature of 100-250°C; it can also be carried out at different temperatures in stages, for example, first curing at 0-90°C, and then curing at 90-250°C Next solidify.

[0060] According to a preferred embodiment of the present invention, the thermal curing includes sequentially performing low-temperature curing at a temperature of 20-40°C and high-temperature curing at a temperature of 150-200°C. In this preferred embodiment, the rubber stopper cured in stages has a lower surface friction coefficient and better UV resistance, chemical resistance and aging resistance.

[0061] Preferably, the low temperature curing time is 12-36 hours, and the hig...

preparation example 1

[0082] The material of the non-siliconization rubber stopper in this embodiment is brominated butyl rubber, including preparing a coating solution from the coating composition, coating the coating solution on the surface of the cleaned and dried rubber stopper and curing the coating. step.

[0083] Among them, the composition of the coating composition is: 100g of hydroxyl-terminated polydimethylsiloxane (viscosity of 3500cSt at 20°C), 1g of H-type β-molecular sieve catalyst (silica-aluminum molar ratio is 25, cylindrical) 1g, Joint agent (KH-570) 100g, organic solvent (n-hexane) 200g.

[0084] The preparation process of the silicone-free rubber plug of the present embodiment, the specific steps are as follows:

[0085] (1) According to the above weight ratio, dissolve the blocked polydimethylsiloxane, coupling agent and catalyst in an organic solvent for contact reaction (contact reaction conditions include: temperature is 95°C, time is 8h), and obtained mixture solution; ...

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Abstract

The present invention relates to the technical field of medicinal rubber plug production, and discloses a silicification-free rubber plug coating composition, which contains two or more of the following components for mixed storage or independent storage: terminated polydimethylsiloxane, a catalyst and a coupling agent, and optionally contains an organic solvent, wherein the catalyst is a beta molecular sieve catalyst. Relative to 100 parts by weight of the terminated polydimethylsiloxane, the content of the catalyst is 0.01 to 3 parts by weight, the content of the coupling agent is 20 to 250 parts by weight, and the content of the organic solvent is 0 to 2000 parts by weight. The silicification-free rubber plug provided by the invention is simple in preparation process, free of influence on the quality of the rubber plug, free of repeated treatment, easy to implement and obvious in effect.

Description

technical field [0001] The present invention relates to the technical field of production of medical rubber stoppers, in particular to a coating composition for siliconization-free rubber stoppers, a method for preparing a coating solution for siliconization-free rubber stoppers, and siliconization-free rubber prepared by the method A coating solution for stoppers and a method for preparing silicone-free rubber stoppers. Background technique [0002] During the production process of rubber stoppers, rubber stopper manufacturers often carry out siliconization treatment on the rubber stoppers, that is, spray a layer of silicone oil on the surface of the rubber stoppers. The lubricity of silicone oil can prevent rubber stoppers from sticking during production and transportation, reduce the particles produced by friction between rubber stoppers, and ensure the normal loading and pressing of rubber stoppers on pharmaceutical filling machines. [0003] However, the technical defe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09D183/04C09D7/61C09D7/63C08J7/04C08L23/28
CPCC09D183/04C09D7/61C09D7/70C09D7/63C08J7/0427C08J2323/28C08J2483/04C08K7/26C08K5/5425C08K5/544C08K5/5435
Inventor 李建华钟林安婷婷王镭宋小飞
Owner CHINA PETROLEUM & CHEM CORP
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