Nanogold biochip for detecting Alzheimer's disease marker as well as preparation method and application of nanogold biochip
An Alzheimer's disease, biochip technology, applied in measurement devices, material excitation analysis, fluorescence/phosphorescence, etc., can solve the problems of not reaching the picogram level, inaccurate results, low sensitivity, etc., and improve the emission intensity. , the effect of improving the detection signal and improving the sensitivity
Pending Publication Date: 2022-03-01
SHENZHEN UNIV +1
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The invention provides a nanogold biochip for detecting an Alzheimer's disease marker and a preparation method and application of the nanogold biochip. Gold nanoparticles are deposited on a chip substrate, so that a plurality of discontinuous gold nanoparticles with uniform intervals are distributed on the surface of the chip; and fixing a capture antibody for detecting the Alzheimer's disease marker on the chip through printing to form a capture layer, thereby obtaining the nanogold biochip. A local electric field is generated due to gaps of the gold nanoparticles, so that the emission intensity of the coupled fluorescent molecules is improved, surface plasmas and the fluorescent molecules resonate, and fluorescence detection signal amplification is realized. The gold nanoparticles can also increase the specific surface area and increase binding sites for capturing the antibody. The near-infrared fluorescent molecules are adopted, so that background fluorescent signals of the substrate can be effectively avoided, and the signal-to-noise ratio is increased. Finally, background noise is reduced by detecting near-infrared fluorescence, a fluorescence output signal is enhanced by the gold nanoparticles, and the sensitivity of Alzheimer's disease biomarker detection is improved.
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Property | Measurement | Unit |
Diameter | 300.0 ~ 500.0 | µm |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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