Anti-infection improved iodine-loaded titanium alloy antibacterial implant and preparation method thereof
A titanium alloy, an improved technology, used in prostheses, coatings, tissue regeneration, etc., can solve problems such as implant infection, and achieve the effects of controllable production process, short production cycle and suitable reaction conditions
Active Publication Date: 2022-03-04
ZHEJIANG UNIV
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[0004] The purpose of the present invention is to provide a technically simplified iodine-loaded titanium alloy implant and a preparation method for the implant infection problem caused by the use of titanium alloy medical materials in the field of surgical orthopedics
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[0026] Attached below Figure 1-3 An improved anti-infection iodine-loaded titanium alloy antibacterial implant of the present invention and its preparation method are further described in detail.
[0027] A kind of anti-infection improved type iodine-loaded titanium alloy antibacterial implant of the present invention and the specific implementation process of preparation method are as follows:
[0028] 1. The titanium alloy base material with a roughness Ra of 0-0.4 μm (provided by Zhejiang Kehui Medical Instrument Co., Ltd.) was pretreated by acetone (≥99.5%), ethylene glycol (≥99.5%), ultrapure water, etc. After treatment, the material was pickled in a solution system containing HF (≥40%, 20ml / L), HNO3 (65.0-68.0%, 80ml / L), H3PO4 (85%, 15ml / L) for 15min, and finally ultrasonic Wash 3 times and blow dry.
[0029] 2. Carry out anodic oxidation operation with the material after step 1 treatment, and its specific steps are as follows: 95.0~98.0wt% sulfuric acid (Sinopharm Ch...
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Abstract
The invention discloses an anti-infection improved iodine-loaded titanium alloy antibacterial implant and a preparation method, the improved iodine-loaded titanium alloy antibacterial implant comprises a titanium alloy material, a porous micro-nano structure is constructed on the surface of the titanium alloy material, and povidone iodine is deposited and attached on the surface of the porous micro-nano structure to form an antibacterial coating. The invention relates to a preparation method of an improved iodine-loaded titanium alloy antibacterial implant, which mainly applies an electrochemical method to perform iodine impregnation on the surface of a micro-arc oxidation titanium alloy, and comprises the following two steps: constructing a porous structure on the surface of the titanium alloy, and performing iodine impregnation improvement treatment and iodine loading. According to the method, an existing titanium alloy surface iodine loading process is improved, so that the material production process is more controllable, and surface antibacterial components are more stable. The process is simple, the reaction conditions are appropriate, the advantages of high efficiency and short production period are achieved, and the obtained titanium alloy implant is quite remarkable in antibacterial effect.
Description
technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to an anti-infection improved iodine-loaded titanium alloy antibacterial implant and a preparation method. Background technique [0002] Despite the rapid development of orthopedic surgery technology in the past ten years, deep tissue infection in the surgical site is still a difficult complication that medical staff must face. Implant-associated infection is the main manifestation of deep infection. More than half of these implant-associated infections were caused by Staphylococcus epidermidis and Staphylococcus aureus. During its pathogenesis, the formation of biofilm is a key link that makes the treatment of such infections difficult. The formation of biofilms provides a protective barrier for bacteria, making them resistant to antibiotics and the body's own immune defense response. Based on the above theories, some scholars have proposed that by modifying the sur...
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IPC IPC(8): A61L27/06A61L27/34A61L27/50A61L27/54A61L27/56C25D11/26
CPCA61L27/06A61L27/34A61L27/50A61L27/54A61L27/56C25D11/026C25D11/26A61L2430/02A61L2300/404A61L2300/202A61L2420/02A61L2420/04A61L2420/06A61L2300/106C08L39/06
Inventor 叶招明叶福林滕王锶源方明朱伟强虞方磊
Owner ZHEJIANG UNIV