Bionic anisotropic hybrid cross-linked hydrogel as well as preparation method and application thereof
A hybrid cross-linking and anisotropic technology, applied in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve the problems of loss of inherent strength, brittle fracture, lack of ductility, etc., and achieve low cost, high toughness, mechanical properties, The effect of excellent biocompatibility
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0037] Add 2.5g of chitosan powder to 50g of LiOH / KOH / urea / H at a weight ratio of 4:6:8:82 2 O solution, after being uniformly dispersed, put it in the refrigerator at -30°C, take it out after 24 hours, and keep the temperature at 5°C for 3 hours to completely thaw, stir evenly and centrifuge at 4000rpm for 10 minutes to remove air bubbles, and obtain a transparent Chitosan alkali solution. Then, the above-mentioned chitosan alkaline solution was poured into a mold, and immersed in 37° C. hot water for 30 minutes to make it gel, so as to convert into alkaline chitosan hydrogel. The alkaline chitosan hydrogel was immersed in deionized water for 3 days to remove residual alkali and urea, and finally chitosan hydrogel was obtained.
[0038] The chitosan hydrogel was placed on a retractable stretching fixture, and pre-stretched to a strain of 20%, then fixed, and kept at a constant temperature in the air until it was completely dry. The drying temperature was 25° C., and the dryi...
Embodiment 2
[0052] Add 2 g of chitosan powder to 50 g of LiOH / KOH / urea / H at a weight ratio of 4:6:8:82 2 O solution, after being uniformly dispersed, put it in the refrigerator at -30°C, take it out after 24 hours, and keep the temperature at 5°C for 3 hours to completely thaw, stir evenly and centrifuge at 4000rpm for 10 minutes to remove air bubbles, and obtain a transparent Chitosan alkali solution. Then, the above-mentioned chitosan alkaline solution was poured into a mold, and immersed in 37° C. hot water for 30 minutes to make it gel, so as to convert into alkaline chitosan hydrogel. The alkaline chitosan hydrogel was immersed in deionized water for 3 days to remove residual alkali and urea, and finally chitosan hydrogel was obtained.
[0053] The chitosan hydrogel is placed on a stretchable stretching fixture, and pre-stretched to a strain of 40%, then fixed, and kept at constant temperature in the air until it is completely dry. The drying temperature is 40° C., and the drying ti...
Embodiment 3
[0058] Add 0.5 g of chitosan powder to 20 g of LiOH / KOH / urea / H at a weight ratio of 4:6:8:82 2 O solution, after being uniformly dispersed, put it in the refrigerator at -30°C, take it out after 24 hours, and keep the temperature at 5°C for 3 hours to completely thaw, stir evenly and centrifuge at 4000rpm for 10 minutes to remove air bubbles, and obtain a transparent Chitosan alkali solution. Then, the above-mentioned chitosan alkaline solution was poured into a mold, and immersed in hot water at 50° C. for 30 minutes to form a cross-link, so as to transform into an alkaline chitosan hydrogel. The alkaline chitosan hydrogel was immersed in deionized water for 3 days to remove residual alkali and urea, and finally chitosan hydrogel was obtained.
[0059] The chitosan hydrogel was placed on a stretchable stretching fixture, and pre-stretched to a strain of 30%, then fixed, and kept at constant temperature in the air until it was completely dry. The drying temperature was 25° C....
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More