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Bionic silk fibroin-based self-driven electrically-controlled drug-loaded patch and preparation method thereof

A vegetal protein and bionic silk technology, applied in electrotherapy, pharmaceutical formulations, electrodes, etc., can solve the problems of large volume and high cost of electronically controlled patches, and achieve the effects of improving delivery efficiency, good feedback control, and broadening the range of choices.

Pending Publication Date: 2022-03-08
THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the need for bulky, expensive energy storage power supplies and complex electronic components to achieve feedback control, the application of electronically controlled patches still faces many challenges.

Method used

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  • Bionic silk fibroin-based self-driven electrically-controlled drug-loaded patch and preparation method thereof
  • Bionic silk fibroin-based self-driven electrically-controlled drug-loaded patch and preparation method thereof
  • Bionic silk fibroin-based self-driven electrically-controlled drug-loaded patch and preparation method thereof

Examples

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preparation example Construction

[0041] The present application also provides a preparation method of a bionic silk fibroin-based self-driven electronically controlled drug-loaded patch, including the following steps:

[0042] Combining the first electrode layer, the first friction layer, the first gasket, the second gasket, the second friction layer and the second electrode layer to obtain a biomimetic silk fibroin-based friction nanogenerator, the first friction layer is Biomimetic silk fibroin layer, the second friction layer is an insulating material layer;

[0043] The conductive film, the drug-loaded patch and the microneedle array are sequentially placed and pressed to obtain the drug-loaded microneedle patch;

[0044] The biomimetic silk fibroin-based triboelectric nanogenerator is connected with the drug-loaded microneedle patch through wires.

[0045] In the present application, in the process of preparing the biomimetic silk fibroin-based self-driven electronically controlled drug-loaded patch, th...

Embodiment 1

[0066] 1) Preparation of biomimetic silk protein membrane: natural silkworm rolls were placed in 0.02M Na 2 CO 3 Boil in the solution for 30min, then rinse with deionized water to remove residual sericin and Na 2 CO 3 , put it in an oven at 50°C and dry it for later use; take the degummed silkworm roll and dissolve it in 9.3M lithium bromide solution at 60°C for 4 hours; pour the cooled silk fibroin solution into a dialysis bag (8000Da), and deionize the water Dialyze for 72 hours, change the water every 3 hours, and then centrifuge the solution to remove impurities;

[0067] Use polydimethylsiloxane (PDMS) to rub the lotus leaf structure to prepare a reverse mold, mix PDMS and crosslinking agent according to the ratio of 10:1, vacuum defoam, and then import it into the acrylic mold where the lotus leaf is fixed. Place it horizontally at room temperature for 24 hours, then place it in an air-blast drying oven at 80°C for 2 hours to cross-link to prepare the reverse mold;

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Abstract

The invention provides a bionic silk fibroin-based self-driven electrically-controlled drug-loaded patch. The bionic silk fibroin-based self-driven electrically-controlled drug-loaded patch comprises a bionic silk fibroin-based friction nano-generator and a drug-loaded microneedle patch connected with the bionic silk fibroin-based friction nano-generator. The invention further provides a preparation method of the self-driven electric control medicine carrying patch. According to the self-driven electronic control medicine carrying patch, the conversion efficiency of converting biological mechanical energy into electric energy and the sensitivity of sensing response are improved, the friction nanometer generator has the self-cleaning function and is environmentally friendly, meanwhile, the medicine delivery efficiency is improved, and the application prospect is wide. And the electrically-controlled drug-loading patch is not limited by the drug-loading capacity, so that the range of the molecular weight of the available drug is widened, and the limitation of preparation conditions when only depending on the drug-loading microneedle array patch is reduced.

Description

technical field [0001] The invention relates to the technical field of polymer biomedical materials, in particular to a bionic silk fibroin-based self-driven electronically controlled drug-loaded patch and a preparation method thereof. Background technique [0002] Transdermal therapeutic skin patches for drug delivery have received increasing attention in recent years. Compared with oral administration and subcutaneous injection, transdermal administration can not only bypass the first-pass effect of the liver and avoid the destruction of the drug in the gastrointestinal tract, but also has the advantages of less toxic side effects, convenient medication, and good patient compliance. [0003] In order to improve the efficiency of transdermal drug delivery, various methods have been explored to enhance skin permeability. Iontophoresis, a physical enhancement method that has been shown to accelerate transdermal penetration, accelerates drug penetration into the skin by apply...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/42A61K50/00
CPCA61K9/0021A61K47/42A61K9/0009A61K9/0097C09J9/02A61M2037/0023A61M37/0015
Inventor 刘颖陈延东陈春英赵宇亮
Owner THE GBA NAT INST FOR NANOTECHNOLOGY INNOVATION
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