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Antibacterial modified hernia repair tablet and preparation method thereof

A hernia repair patch and hernia repair technology, which is applied in the field of antibacterial modified hernia patch and its preparation, can solve the problems that drugs do not have long-term antibacterial effects, are not suitable for mass production, and have a narrow application range of antibacterial patches. Reduce the risk of postoperative infection, increase the success rate of surgery, and the effect of long-term antibacterial ability

Pending Publication Date: 2022-03-08
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides an antibacterial modified hernia repair patch and a preparation method thereof. Matching, thus limiting the application of a large number of antibacterial drugs, the drug release cycle does not have a long-term antibacterial effect, and the preparation process is cumbersome, not suitable for mass production.

Method used

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  • Antibacterial modified hernia repair tablet and preparation method thereof

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preparation example Construction

[0018] The preparation method of the antibacterial modified hernia repair patch provided by the present invention does not change the overall properties of the original patch, so that it has antibacterial properties, and the specific technical scheme is as follows:

[0019] A preparation method for an antibacterial modified hernia repair sheet, comprising the steps of:

[0020] S1, preparing the first spinning solution, subjecting the first spinning solution to electrospinning treatment for the first time to obtain a layer of electrospun nanofiber membrane, preparing a second spinning solution, and placing the second spinning solution in the first spinning solution The second electrospinning process is carried out on the first layer of electrospun nanofiber membrane to obtain two layers of electrospun nanofiber membrane, and the third spinning solution is prepared, and the third spinning solution is carried out on the two layers of electrospun nanofiber membrane. In the third ...

Embodiment 1

[0029] (1) Dissolve polyvinylidene fluoride in a mixed solvent of N,N-dimethylformamide (DMF) and acetone (Ace) with a volume ratio of 3:1, and prepare a spinning solution with a mass volume ratio of 25% (The first spinning solution), through electrospinning and spinning with a drum as a receiver, to obtain a layer of electrospun nanofiber membrane.

[0030] (2) Dissolve the polylactic acid-glycolic acid copolymer in a mixed solvent of N,N-dimethylformamide (DMF) and acetone (Ace) with a volume ratio of 1:1, and prepare a spinning solution with a mass volume ratio of 45%. The silk solution (second spinning solution) is continuously spun on the basis of one layer of electrospun nanofiber membrane in step (1) to obtain two layers of electrospun nanofiber membrane.

[0031] (3) Dissolve polyvinylidene fluoride in a mixed solvent of N,N-dimethylformamide (DMF) and acetone (Ace) with a volume ratio of 3:1, and prepare a spinning solution with a mass volume ratio of 25%. (The third...

Embodiment 2

[0038] (1) Dissolve polyvinylidene fluoride in a mixed solvent of N,N-dimethylformamide (DMF) and acetone (Ace) with a volume ratio of 3:1, and prepare a spinning solution with a mass volume ratio of 30%. (The first spinning solution), through electrospinning and spinning with a drum as a receiver, to obtain a layer of electrospun nanofiber membrane.

[0039](2) Mix polylactide-glycolide copolymer and poly-L-methoxypolyethylene glycol block copolymer (PELA) at a mass ratio of 7:1, and dissolve the mixed material in N,N- Dimethylformamide (DMF) and acetone (Ace) volume ratio is in the mixed solvent of 1:1, is mixed with the spinning solution (the second spinning solution) that mass volume ratio is 50%, in step (1) Continue spinning on the basis of one layer of electrospun nanofiber membrane to obtain two layers of electrospun nanofiber membrane.

[0040] (3) Dissolve polyvinylidene fluoride in a mixed solvent of N,N-dimethylformamide (DMF) and acetone (Ace) with a volume ratio...

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Abstract

The invention belongs to the technical field of biological materials, and particularly relates to an antibacterial modified hernia repair tablet and a preparation method thereof. According to the preparation method of the antibacterial modified hernia repair patch, the overall property of an original patch is not changed, and on the atomic level, plasma provides enough energy to destroy bonding on a polymer, so that when active sites are formed on the surface and new functional groups are generated, surface modification is carried out, and amino groups are grafted to the surface of the polymer through glow discharge. According to the antibacterial modified hernia repair patch, only the surface of the antibacterial modified hernia repair patch is activated and modified, the obtained antibacterial modified hernia repair patch has long-acting antibacterial ability, the original porous fiber structure of the patch is not damaged, cell ingrowth and biological activity expression are facilitated, and the process is simple and convenient to operate and easy for industrial production.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to an antibacterial modified hernia repair sheet and a preparation method thereof. Background technique [0002] Hernia repair mesh is mainly used in the repair of abdominal wall hernia, including inguinal hernia, umbilical hernia, femoral hernia, incisional hernia and parastomal hernia, among which inguinal hernia is the most common. Due to the high morbidity, hernia repair mesh is widely used in the repair of abdominal wall incision. Compared with traditional treatment methods, patch repair has the characteristics of simple operation and short repair period, but the site where the patch is implanted is prone to infection. Therefore, improving the durable anti-infection performance of the patch has become a research focus. In the preparation of the existing antibacterial patches, most of the drugs are used as antibacterial agents. In the preparation proces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/18A61L27/54A61L27/56A61L27/58D04H1/728D04H1/4374
CPCD04H1/728D04H1/4374A61L27/54A61L27/56A61L27/16A61L27/18A61L27/58A61L2400/12A61L2300/404
Inventor 栗可心郑志国张向东张传文曹阳
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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