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Application of programmable immunocompetence carbon fiber-molybdenum disulfide composite material in preparation of wound healing medicine

A composite material and wound healing technology, applied in the direction of molybdenum sulfide, carbon fiber, drug combination, etc., can solve the problems of not being able to achieve the optimal treatment effect, accelerate wound healing, etc., and achieve the effect of promoting wound healing and accelerating wound healing

Pending Publication Date: 2022-03-15
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are currently some materials that can be used for antibacterial or promoting cell proliferation and angiogenesis in wounds, they only promote individual stages in wound healing, and the whole process of wound healing is continuous and complex, and only promotes a single Unable to achieve optimal therapeutic effect at a certain stage
All in all, most of the currently reported materials for wound healing cannot simultaneously meet the requirements of simple synthesis process, good biocompatibility, strong antibacterial ability, and favorable cell proliferation to efficiently accelerate wound healing.

Method used

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  • Application of programmable immunocompetence carbon fiber-molybdenum disulfide composite material in preparation of wound healing medicine
  • Application of programmable immunocompetence carbon fiber-molybdenum disulfide composite material in preparation of wound healing medicine
  • Application of programmable immunocompetence carbon fiber-molybdenum disulfide composite material in preparation of wound healing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1MoS 2 Preparation of Nanomaterials

[0026] First use an analytical balance to weigh 150 mg (NH 4 ) 2 MoS 4 Dissolved into 30 mL of pure water by strong magnetic stirring (500 rpm) to obtain a homogeneous solution, then the solution was transferred to a 50 mL polyphenylene-lined stainless steel autoclave and kept at 220 °C for 12 h. Finally, the obtained black product (MoS 2 nanomaterials) were washed three times with ethanol and deionized water respectively and redispersed in pure aqueous solution for further use.

Embodiment 2

[0027] Example 2ACF-MoS 2 Preparation of composite materials

[0028] First, the carbon fiber (CF) was refluxed in acetone solution for 10 h, then soaked in concentrated nitric acid for about 4 h, and washed with pure water until neutral to obtain activated carbon fiber (ACF). Using N,N-dimethylformamide (DMF) as solvent and reducing agent, (NH 4 ) 2 MoS 4 MoS on ACF as precursors of molybdenum and sulfur 2 Functional. Concrete steps include: take 300mg ACF and 150mg (NH 4 ) 2 MoS 4 Put them together in a mixture of 15 mL DMF and 15 mL pure water to obtain a homogeneous solution, then transfer the solution into a 50 mL polyphenylene-lined stainless steel autoclave and keep at 220 °C for 12 h. Finally, the obtained black product (ACF-MoS 2 composites) were washed three times with ethanol and deionized water respectively and redispersed in pure aqueous solution for further use. ACF-MoS obtained by inductively coupled plasma emission spectrometer (ICP) test 2 The conte...

Embodiment 3

[0030] Example 3 Study of ACF-MoS 2 Effect of Composite Materials on Macrophage Polarization

[0031] RAW264.7 cells (mouse mononuclear macrophage leukemia cells) were plated in 6-well plates and cultured for 24 hours, and then treated with equal amounts of different materials (Control, ACF, MoS 2 , ACF-MoS 2 ) to treat cells and perform NIR (0.75W / cm 2) light treatment. After continuing to culture for 6 h, the cells were washed twice with PBS, and the cells were lysed and centrifuged down (1000 rpm, 6 min). Raw 264.7 cells induced by different conditions were collected, and the expressions of surface marker antigens CD80 (M1 macrophage marker) and CD206 (M2 macrophage marker) in each group were detected by flow cytometry.

[0032] figure 2 for ACF-MoS 2 Effect diagram of the composite material on the polarization of macrophages, where (a-c) respectively represent: (a): Each group (1: Control; 2: ACF; 3: Mo S 2 ;4:ACF-MoS 2 ;5:Control+Laser;6:ACF+Laser;7:MoS 2 +Laser...

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Abstract

The invention provides application of a programmable immunocompetence carbon fiber-molybdenum disulfide composite material in preparation of a wound healing medicine. It is found for the first time that the ACF-MoS2 composite material can control the time of a wound in an inflammation stage and a proliferation stage by intelligently adjusting polarization of macrophages through light control, so that wound healing is efficiently promoted. According to the invention, a new application of the ACF-MoS2 composite material is developed, and a new idea is provided for exploring a novel composite material with multiple functions. The ACF-MoS2 composite material combines the respective advantages of ACF and MoS2, integrates excellent properties such as photo-thermal performance, heat-conducting property, mimic enzyme activity and biocompatibility, and is capable of efficiently sterilizing and promoting inflammation in the early stage of wound healing; in the later stage of wound healing, oxidative stress of a wound part is eliminated, cell proliferation and tissue reconstruction are promoted, and wound healing is accelerated.

Description

technical field [0001] The invention relates to a new application of a composite material, in particular to the application of a programmable immunoactive carbon fiber-molybdenum disulfide composite material in the preparation of wound healing medicine. Background technique [0002] Carbon fiber (CF) / molybdenum disulfide (MoS 2 ) composite material is a sustainable clean energy that has received widespread attention since the new century. It is widely used in the field of electrocatalytic hydrogen evolution, such as Wan Meng et al. Journal of Inorganic Chemistry, 2017,33(04):595-600; Li Weibin et al .Journal of Materials Science and Engineering, 2015,33(03):410-414; Chinese patent with publication number CN110961122A, etc. The composite material mostly utilizes MoS 2 The high catalytic activity of nanosheets and the high specific surface area, good stability, and high conductivity of CF are used to study the application of composite materials with different shapes and str...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/44A61K33/24A61P17/02A61P31/04A61P31/10A61P29/00C01G39/06D06M11/53D06M101/40
CPCA61K41/0052A61K33/44A61K33/24A61P17/02A61P31/04A61P31/10A61P29/00C01G39/06D06M11/53C01P2002/80C01P2004/03D06M2101/40A61K2300/00
Inventor 李奚毛梦欣
Owner CHANGCHUN UNIV OF TECH
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