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Novel preparation process of octylphenol polyoxyethylene ether

A technology of octylphenol polyoxyethylene ether and octylphenol, applied in the field of octylphenol polyoxyethylene ether OP-9 and its production process, to achieve good emulsification and low impurity content

Pending Publication Date: 2022-03-22
江苏保易制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to technical problems, OP-9 currently available in the domestic market contains harmful and toxic impurities such as ethylene glycol, diglycol, triglycol, ethylene oxide, and dioxane (dioxin).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] An octylphenol polyoxyethylene ether OP-9, the raw materials are composed according to the following weight: octylphenol: 25kg, ethylene oxide: 45kg, sodium methoxide: 25g, phosphoric acid: 0.8kg.

[0018] Put octylphenol and catalyst into the reactor, heat to 85-90°C to dissolve, raise the temperature to 105-110°C and dehydrate under reduced pressure until the water content is ≤0.01%, slowly add ethylene oxide to the reactor after drying, and control the pressure -0.1~ 0.3MPa, temperature 110 ~ 140 ℃ reaction. After the calculated amount of ethylene oxide is added, it is aged for 1 hour, degassed under reduced pressure for 1 hour, and neutralizing agent is added until pH=6-7. Add adsorbent, filter for 0.5 to 1 hour after adsorption, and obtain a colorless to pale yellow liquid, which is lighter than the yellow No. 2 standard solution.

Embodiment 2

[0020] An octylphenol polyoxyethylene ether OP-9, the raw materials are composed according to the following weight: octylphenol 30kg, ethylene oxide: 60kg, potassium hydroxide: 600kg, acetic acid: 1.0kg.

[0021] Its preparation process is with embodiment 1.

Embodiment 3

[0023] An octylphenol polyoxyethylene ether OP-9, the raw materials are composed according to the following weight: octylphenol: 27kg, ethylene oxide: 54kg, potassium hydroxide: 54g, acetic acid: 0.9kg.

[0024] Its preparation process is with embodiment 1.

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PUM

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Abstract

The invention aims to provide octylphenol polyoxyethylene ether OP-9 and a preparation process thereof. The technical scheme adopted by the invention is as follows: the octylphenol polyoxyethylene ether OP-9 is prepared from the following raw materials in parts by weight: 25 to 30 parts of octylphenol, 45 to 63 parts of ethylene oxide, 0.025 to 0.075 part of catalyst and 0.8 to 1.0 part of neutralizer. The composition has the advantages of nonylphenol polyoxyethylene ether OP-9, has good emulsifying, dispersing and antistatic properties, is low in impurity content and harmless to a human body, and is suitable for ophthalmic medicines.

Description

technical field [0001] The invention relates to an octylphenol polyoxyethylene ether OP-9 and a production process thereof. Background technique [0002] Octylphenol polyoxyethylene ether is a product obtained by polymerization of p-tertoctylphenol (CAS: 140-66-9, also known as octylphenol) and ethylene oxide. Due to different degrees of polymerization, it is divided into OP-4, OP -7, OP-9, OP-10, OP-13, OP-15, OP-20, OP-30, OP-40, OP-50, etc., are a type of emulsifier commonly used in industry, with good emulsification , Dispersion, antistatic properties. [0003] Among them, OP-9, that is, octylphenol polyoxyethylene (9) ether, is the polymerization of octylphenol and ethylene oxide in a molar ratio of 1:9, and is currently a commonly used antibacterial agent in the pharmaceutical industry, especially ophthalmic preparations. [0004] Now the domestic commercially available OP-9 has harmful and toxic impurities such as ethylene glycol, diglycol, triglycol, ethylene oxide...

Claims

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Application Information

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IPC IPC(8): C08G65/28
CPCC08G65/2612
Inventor 何飞
Owner 江苏保易制药有限公司
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