Preparation process, device and application of a kind of selenized chitosan oligosaccharide

Abstract

The invention belongs to the technical field of organic selenium preparation, and specifically relates to a preparation process, device and application of selenized chitosan oligosaccharide; Sodium acid is added to the chitosan oligosaccharide solution for ultrasonic treatment; the reacted mixed solution is subjected to centrifugal dialysis; the reaction concentrate is subjected to suction filtration, and then the filtrate obtained by suction filtration is concentrated under reduced pressure; Add absolute ethanol, stand still after precipitation occurs, and centrifuge to wash and dry the precipitate with absolute ethanol; the device includes a rack, a stirring mixing tank, a temperature-controlled ultrasonic treatment tank, a centrifugal dialysis concentration device and a control box; the present invention The catalyst of the disclosed preparation device is nickel particles attached to the heat dissipation fin group, and there is no need to filter the catalyst after the reaction, and the acetic acid smell that acetic acid is easy to emit can also be completely filtered to remove the peculiar smell and then discharged, optimizing the reaction steps and workshop environment.

Description

A kind of preparation technology, device and application of selenized oligomeric chitosan technical field The invention belongs to the technical field of machine selenium preparation, be specifically related to a kind of preparation technology, device of selenized oligochitosan and applications. Background technique Chitosan, as a kind of cationic polysaccharide, has excellent biocompatibility, biodegradability, and no toxic side effects at the same time. use. Selenium is one of the essential trace elements for the human body. Selenium is mainly involved in antioxidant, thyroid hormone synthesis and immune function in the body. Deficiency of selenium in the body can cause several chronic diseases such as cancer. With the development of chitosan metal complexes The further understanding of the compound, combined with the good biological activity of organic selenium compounds, people's research on chitosan selenium is also more and more. The oligomerization promot...

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Problems solved by technology

The preparation process of the selenized chitosan oligosaccharide disclosed by this invention has simple steps, strong operability, and high selenium content in the product, but in the process of realizing its industrial production, the ultrasonic treatment in the second step will often reduce the temperature of the reaction solution increase, and when the temperature of sodium selenite is too high, selenous acid will decompose, which is unfavorable for the carrying out of the reaction, and the temperature increase will cause the further hydrolysis of oligomeric amino polysaccharides, thereby reducing the yield of the product. Therefore, the preparation process also often intermittently feeds nitrogen to reduce the temperature of the reaction solution during the production process.

But because the solvent of this reaction solution is acetic acid solution, and acetic acid solution has the property of volatilization, in carrying out the industrialized production process of above-mentioned selenized oligomeric amino polysaccharide, acetic acid solution tends to give off a pungent sour taste, and to react Nitrogen is passed into the solution, and the nitrogen can further take the acetic acid out of the reactor, making the whole workshop full of peculiar smell

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