Extraction process for optimizing three effective components of cortex dictamni by combining analytic hierarchy process with response surface method
A technology of response surface method and extraction process, which is applied in the field of extraction process of three active components of Cortex alba in combination with AHP combined with response surface method
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Embodiment approach 1
[0019] Extraction and content determination of embodiment one whitewash
[0020] The drawing of embodiment one standard curve
[0021] Take 1 mg of the standard substance of white chloric acid, alkone, and phellodendron, and make 0.004, 0.006, 0.008, 0.01, 0.012 mg / mL standard solution of white christine, 0.016, 0.020, 0.024, 0.028, 0.032 mg / mL of arketone Standard solution and 0.03, 0.04, 0.05, 0.06, 0.07mg / mL Phellodendron standard solution. The absorbance A of standard solutions of different concentrations of whitewash, alkone and phellodendron was measured by UV at 236 nm, 218 nm, and 212 nm wavelength respectively. With the concentration as the abscissa and the absorbance as the ordinate, draw the standard curve of the three standard substances. Each group was measured three times, the average value was calculated, and the content was calculated according to the formula.
[0022] Formula (1-1)
[0023] Formula (1-2)
[0024] Formula (1-3)
[0025] Formula ...
Embodiment approach 2
[0028] Embodiment 2 Fresh Cortex Single Factor Experiment
[0029] Investigate four factors: solid-liquid ratio, extraction time, ethanol concentration, and extraction times. Under each factor, 5 levels were selected, and then the experiment was carried out under the condition that the other three factors were fixed, and the contents of the three active ingredients were compared. Taking the contents of the three active ingredients as reference factors, the optimal level of single factor was screened out, and the experiment was repeated three times.
[0030] (1) Effect of solid-liquid ratio on content of three active ingredients
[0031] Accurately weigh 3 g of white fresh cortex, fix the extraction temperature at 80°C, extract for 1.5 h, ethanol concentration 80%, extract once, and the ratio of solid to liquid is 1: 5 g / mL, 1: 10 g / mL , 1:15 g / mL, 1:20 g / mL, and 1:25 g / mL, each group was paralleled to three groups, and the effects of different material-liquid ratios on the c...
Embodiment approach 3
[0043] The establishment of the comprehensive weight of the three active components of the white fresh cortex by the three-chromatographic analysis method of the implementation scheme
[0044] Analytic hierarchy process was used to establish comprehensive weights for the three constituent indexes of white fresh alkaloid, alkone and phellodendron. According to the above single factor experimental results, according to the extraction amount of the three indicators, the priority order of the three active ingredients was preliminarily determined to be cortex ketone > ash ketone > clarinetine, so as to construct the priority judgment matrix for the target pairwise comparison, and assign The relative score of each indicator. The results are shown in Table 1-2.
[0045] (1) Scoring criteria for each index component
[0046] Table 1 Scoring criteria for each level of evaluation indicators
[0047]
[0048] Table 2 Priority judgment matrix for target component pair comparison
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