Preparation method of wound dressing for relieving scar generation
A wound dressing and scar technology, which is applied in the field of biomedical engineering, can solve the problems of scar reduction, prevent the imbalance of collagen synthesis and degradation, promote rapid degradation, and promote activation and differentiation.
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Embodiment 1
[0025] 1. Take the illite powder with a particle size of 25nm, and in a vacuum of 5mmHg, 480W ultrasonic, wash with a mass fraction of 12% perchloric acid solution, then wash with 50g / L sodium hydroxide solution, and then wash with pure water to medium properties, vacuum-dried to obtain activated illite nanopowder;
[0026] 2. Take 1.2g of TPU particles, 115mg of activated illite nanopowder prepared in step 1, 72mg of hyaluronic acid, 30mg of hematin, 2mg of hirudin, and 1.3mg of thymosin β4, add them to 10mL of DMF, and stir at 4°C to obtain a core layer spinning silk liquid;
[0027] 3. Take 7mg of collagenase with a specific activity of 240CDU / mg, 115mg of activated illite nanopowder prepared in step 1, add 10mL of hexafluoroisopropanol, stir overnight at 4°C, then add 800mg of collagen and 28mg of Panax notoginseng extract, Stir at 4°C to obtain a shell spinning solution;
[0028] 4. Using a 10mL syringe, the voltage of the No. 7 flat needle is 18KV, the distance is 12cm...
Embodiment 2
[0031] 1. Take the illite powder with a particle size of 20nm, and wash it with 10% perchloric acid solution, then 40g / L sodium hydroxide solution, and then wash it with pure water until medium properties, vacuum-dried to obtain activated illite nanopowder;
[0032] 2. Take 1g of TPU particles, 120mg of activated illite nanopowder prepared in step 1, 50mg of hyaluronic acid, 34mg of hematin, 1mg of hirudin, and 1mg of thymosin β4, and add them to 10mL of DMF, and stir at 4°C to obtain a core spinning solution ;
[0033] 3. Take 5mg of collagenase with a specific activity of 300CDU / mg, 120mg of activated illite nanopowder prepared in step 1, add 10mL of hexafluoroisopropanol, stir overnight at 4°C, then add 500mg of collagen and 20mg of Panax notoginseng extract, Stir at 4°C to obtain a shell spinning solution;
[0034] 4. Using a 10mL syringe, the voltage of the No. 7 flat needle is 15KV, the distance is 15cm, the injection rate of the core layer is 0.3mL / h, the injection ra...
Embodiment 3
[0037] 1. Take the illite powder with a particle size of 30nm, and wash it with 20% mass fraction of perchloric acid solution, then with 80g / L sodium hydroxide solution, and then with pure water to medium properties, vacuum-dried to obtain activated illite nanopowder;
[0038] 2. Take 1.3g of TPU particles, 100mg of activated illite nanopowder prepared in step 1, 80mg of hyaluronic acid, 20mg of hematin, 3mg of hirudin, and 2mg of thymosin β4, and add them to 10mL of DMF, stir at 4°C to obtain the core layer spinning liquid;
[0039] 3. Take 8mg of collagenase with a specific activity of 125CDU / mg, 100mg of activated illite nanopowder prepared in step 1, add 10mL of hexafluoroisopropanol, stir overnight at 4°C, then add 900mg of collagen and 50mg of Panax notoginseng extract, Stir at 4°C to obtain a shell spinning solution;
[0040] 4. Use a 10mL syringe, the voltage of the No. 7 flat needle is 20KV, the distance is 10cm, the core layer injection rate is 0.7mL / h, the shell l...
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