Preparation method of wound dressing for relieving scar generation

A wound dressing and scar technology, which is applied in the field of biomedical engineering, can solve the problems of scar reduction, prevent the imbalance of collagen synthesis and degradation, promote rapid degradation, and promote activation and differentiation.

Active Publication Date: 2022-04-15
青岛海氏海脉国际健康产业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional wound dressings only have the effect of anti-wound infection and promoting wound healing, but do not have the effect of reducing scars

Method used

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  • Preparation method of wound dressing for relieving scar generation
  • Preparation method of wound dressing for relieving scar generation
  • Preparation method of wound dressing for relieving scar generation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Take the illite powder with a particle size of 25nm, and in a vacuum of 5mmHg, 480W ultrasonic, wash with a mass fraction of 12% perchloric acid solution, then wash with 50g / L sodium hydroxide solution, and then wash with pure water to medium properties, vacuum-dried to obtain activated illite nanopowder;

[0026] 2. Take 1.2g of TPU particles, 115mg of activated illite nanopowder prepared in step 1, 72mg of hyaluronic acid, 30mg of hematin, 2mg of hirudin, and 1.3mg of thymosin β4, add them to 10mL of DMF, and stir at 4°C to obtain a core layer spinning silk liquid;

[0027] 3. Take 7mg of collagenase with a specific activity of 240CDU / mg, 115mg of activated illite nanopowder prepared in step 1, add 10mL of hexafluoroisopropanol, stir overnight at 4°C, then add 800mg of collagen and 28mg of Panax notoginseng extract, Stir at 4°C to obtain a shell spinning solution;

[0028] 4. Using a 10mL syringe, the voltage of the No. 7 flat needle is 18KV, the distance is 12cm...

Embodiment 2

[0031] 1. Take the illite powder with a particle size of 20nm, and wash it with 10% perchloric acid solution, then 40g / L sodium hydroxide solution, and then wash it with pure water until medium properties, vacuum-dried to obtain activated illite nanopowder;

[0032] 2. Take 1g of TPU particles, 120mg of activated illite nanopowder prepared in step 1, 50mg of hyaluronic acid, 34mg of hematin, 1mg of hirudin, and 1mg of thymosin β4, and add them to 10mL of DMF, and stir at 4°C to obtain a core spinning solution ;

[0033] 3. Take 5mg of collagenase with a specific activity of 300CDU / mg, 120mg of activated illite nanopowder prepared in step 1, add 10mL of hexafluoroisopropanol, stir overnight at 4°C, then add 500mg of collagen and 20mg of Panax notoginseng extract, Stir at 4°C to obtain a shell spinning solution;

[0034] 4. Using a 10mL syringe, the voltage of the No. 7 flat needle is 15KV, the distance is 15cm, the injection rate of the core layer is 0.3mL / h, the injection ra...

Embodiment 3

[0037] 1. Take the illite powder with a particle size of 30nm, and wash it with 20% mass fraction of perchloric acid solution, then with 80g / L sodium hydroxide solution, and then with pure water to medium properties, vacuum-dried to obtain activated illite nanopowder;

[0038] 2. Take 1.3g of TPU particles, 100mg of activated illite nanopowder prepared in step 1, 80mg of hyaluronic acid, 20mg of hematin, 3mg of hirudin, and 2mg of thymosin β4, and add them to 10mL of DMF, stir at 4°C to obtain the core layer spinning liquid;

[0039] 3. Take 8mg of collagenase with a specific activity of 125CDU / mg, 100mg of activated illite nanopowder prepared in step 1, add 10mL of hexafluoroisopropanol, stir overnight at 4°C, then add 900mg of collagen and 50mg of Panax notoginseng extract, Stir at 4°C to obtain a shell spinning solution;

[0040] 4. Use a 10mL syringe, the voltage of the No. 7 flat needle is 20KV, the distance is 10cm, the core layer injection rate is 0.7mL / h, the shell l...

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Abstract

The invention belongs to the technical field of biomedical engineering, and discloses a preparation method of a wound dressing for relieving scar generation, which comprises the following steps: (1) activating illite nano powder; (2) adding TPU particles, the activated illite nano powder, hyaluronic acid, dracorhousin, hirudin and thymosin beta4 into DMF (Dimethyl Formamide), and stirring at 4 DEG C to obtain a core layer spinning solution; (3) taking collagenase and the activated illite nano powder, adding hexafluoroisopropanol, stirring at 4 DEG C overnight, adding collagen and a pseudo-ginseng extract, and stirring at 4 DEG C to obtain a shell spinning solution; (4) preparing nanofibers through coaxial electrospinning; and (5) coating the PVP layer. The prepared wound dressing can stop bleeding and resist bacteria in the early stage of wound healing and remove extravasated blood and resist scars in the later stage of wound healing.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to a preparation method of a wound dressing for reducing scar formation. Background technique [0002] The formation of scars is caused by the body's inflammatory response, the imbalance of collagen synthesis and degradation, the appearance of abnormal mucopolysaccharides, and the proliferation of fibroblasts. At the same time, the subcutaneous congestion does not coagulate, causing the scar to gradually change from light red to dark. Conventional wound dressings only have the effect of anti-wound infection and promoting wound healing, but do not have the effect of reducing scars. Contents of the invention [0003] In view of this, the object of the present invention is to provide a method for preparing a wound dressing that can reduce scar formation, and the wound dressing can stop bleeding at the initial stage of wound healing, and is anti-scar that r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/44A61L15/46A61L15/40A61L15/28A61L15/32A61L15/38
Inventor 鞠雨晴汤佳鹏葛彦朱俐
Owner 青岛海氏海脉国际健康产业有限公司
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