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Abrus precatorius extract with anti-allergic effect as well as preparation method and application of abrus precatorius extract

An acacia seed and extract technology, which is applied in the field of acacia seed extract and its preparation, can solve the problems of single action site, not enough to meet the needs of treatment, easy to produce drug resistance, etc., achieve stable treatment, enhance pharmacological effects and clinical Curative effect, the effect of facilitating industrialized large-scale production

Pending Publication Date: 2022-04-29
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have fast effects, but have a single site of action. Common adverse reactions include dizziness, drowsiness, dry mouth and nausea, and long-term use is prone to drug resistance
Facing the high incidence of allergic diseases, existing drugs are not enough to meet the treatment needs, so it is necessary to develop new efficient and safe anti-allergic drugs

Method used

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  • Abrus precatorius extract with anti-allergic effect as well as preparation method and application of abrus precatorius extract
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  • Abrus precatorius extract with anti-allergic effect as well as preparation method and application of abrus precatorius extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: the preparation of acacia extract

[0043] 1.1 Preparation of Acacia extract

[0044] Dry the whole herb of Abrus precatorius L. without pods as the raw material, crush the medicinal materials and pass through a 40-mesh sieve, heat and reflux extraction with 4 times the amount of 75% ethanol twice, each time for 2 hours, combine the extracts, recover under reduced pressure to obtain Acacia Total Extract (APT).

[0045] According to the 1:3 ratio of the total extract of Acacia chinensis (APT) and the resin, the AB-8 macroporous resin column was eluted, first eluted with 4 times the volume of water, discarded the water eluate, and then washed with 4 times the volume of 30 % ethanol solution and 8 times the volume of 75% ethanol solution were eluted respectively, the ethanol eluate was collected, concentrated under reduced pressure at 60°C, and dried to constant weight to obtain the effective parts of Acacia 30% alcohol extract (APFT) and Acacia acacia 75...

Embodiment 2

[0057] Example 2: Research on the Enrichment and Purification Process of Acacia Seed Extract

[0058] A single factor test combined with response surface methodology was established to optimize the enrichment and purification process of macroporous adsorption resin for the extract of Acacia chinensis. The total alkaloid extract of Acacia chinensis can be enriched and purified by using AB-8 macroporous adsorption resin. After analysis by Design-Expert8.0.5 software, the order of influence on the recovery rate of total flavonoids during the enrichment process is sample amount > elution The volume of solvent > the concentration of eluent, the optimal enrichment process obtained after optimization by the response surface method is: the loading volume is 1:3, the volume of eluent is 8 times the volume, and the concentration of eluent is 75% ethanol. Under these conditions, 3 groups of parallel experiments were carried out to verify that the average recovery rate of total flavonoids...

Embodiment 3

[0091] Example 3: Antiallergic Effect Evaluation of Acacia Extract

[0092] 3.1 In vitro inhibition of hyaluronidase method to evaluate anti-allergic activity

[0093] In this experiment, the improved Elson-Morgan method was used to measure the inhibitory rate of different concentrations of Acacia extract APAT on hyaluronidase. Hyaluronidase participates in type I allergy, and is highly related to inflammation and allergy. Various drugs that release histamine from mast cells can regulate hyaluronidase activity. Some antiallergic drugs can strongly inhibit hyaluronidase activity, so in vitro inhibition Hyaluronidase activity can be used as an index to evaluate the anti-allergic effect.

[0094] 3.1.1 Evaluation test method

[0095] Take 0.5mL hyaluronidase (600-1000U / mL) into a stoppered test tube, add 0.1mL of 2.5mmol / LCaCl 2 , kept at 37°C for 20min; added 0.5mL of Acacia extract APAT sample solution with concentrations of 0.5, 0.25, 0.125, and 0.0625g / mL, and kept at ...

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Abstract

The invention belongs to the field of ethnic traditional Chinese medicines, and particularly relates to an abrus precatorius extract with an anti-allergic effect as well as a preparation method and application of the abrus precatorius extract. The abrus precatorius extract disclosed by the invention is abrus precatorius total alkaloids prepared by adopting a specific extraction and purification method. The abrus precatorius extract disclosed by the invention can be prepared into various oral or external medicinal preparations with an anti-allergic effect. The abrus precatorius extract or the pharmaceutical preparation of the abrus precatorius extract can be used for preparing medicines for treating various types of allergic diseases, wherein the allergic diseases comprise pollinosis, allergic rhinitis and allergic dermatitis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and ethnic medicine, and in particular relates to an acacia extract with antiallergic effect, a preparation method and application thereof. Background technique [0002] Allergic reactions are tissue damage or dysfunctional reactions caused by the immune response triggered by the body after exposure to antigen stimulation, also known as allergic reactions. According to the pathogenesis, it can be divided into types I-IV, of which type I: such as bronchial asthma, Allergic rhinitis, gastrointestinal and skin allergic reactions; type II: such as hemolytic anemia, neutropenia and thrombocytopenic purpura; type III: such as serum sickness, systemic lupus erythematosus; type IV: such as contact dermatitis, eczema sexual response, etc. The most common type I allergic reaction mediated by IgE, also known as timely allergic reaction. The number of allergens is large and the source is wide. In...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P37/08A61P17/00A61P11/02
CPCA61K36/48A61P37/08A61P17/00A61P11/02A61K2236/333A61K2236/39A61K2236/55
Inventor 王甜夏建珍张玮肖兰岳丽君唐丽
Owner MINZU UNIVERSITY OF CHINA
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