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Care compositions and uses thereof

A technology of composition and use, applied in the direction of drug combination, active ingredients of iodine compounds, plant raw materials, etc., can solve problems such as insufficient proof to regulate mucus, body burden, etc.

Pending Publication Date: 2022-05-03
苏珍仪 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the current drug treatment method will cause a serious burden on the body in the long run
[0007] In addition, current studies believe that goblet cells are the main defense line of mucosal tissue. Therefore, the number of goblet cells has been used to judge the secretion of nasal mucus so far. However, the analysis of the number of goblet cells is not enough to prove the ability to regulate mucus secretion. can effectively improve

Method used

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  • Care compositions and uses thereof
  • Care compositions and uses thereof
  • Care compositions and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: the preparation method of nursing composition of the present invention

[0068] (A) Drying: place sweet potato leaves, jicama and / or yam leaves in an oven at 70°C, dry until the water content remains 5-7%, and remove water to reduce the activity of organic matter and prevent organic matter from chelating metal ions (The general process does not use drying method).

[0069] (B) Grinding: Take the dried sweet potato leaves, jicama and / or yam leaves, put them into a planetary ball mill, and grind the sweet potato leaves, jicama and / or yam leaves into powder, the size of which should be between 1um~0.1um, To increase the contact area to increase the subsequent ion dissolution rate.

[0070] (C) The liquid carbon dioxide is pressurized to above the critical pressure (higher than 72.9atm) by a high-pressure pump (pump, bump), and flows through the heat exchanger to make the high-pressure liquid carbon dioxide into a supercritical state, and then the supercritic...

Embodiment 2

[0076] Embodiment 2: reduce cellular inflammatory response

[0077] Rat basophil RBL-2H3 was mixed with 5×10 4 Cells were grown in 96-well cell culture dishes. placed in 5% CO 2 , After culturing overnight in a cell culture box at 37°C, remove the culture medium, and add nursing compositions (hereinafter referred to as AMDS) with different dilution ratios (1 / 1600, 1 / 800, 1 / 400, 1 / 200 and 1 / 100) With the control substance (blank control group, positive control group Quercetin), A23187 (1 μg / mL) was added half an hour later for 1 hour of action. The supernatant was taken to measure the content of β-hexosaminidase with a disc enzyme immunoassay (ELISA) instrument. In addition, the cell culture solution was replaced with 0.5 mg / mL MTT solution and cultured for 2 hours. Remove the MTT solution, add 150 μL of DMSO and let it stand at room temperature for 10 minutes to dissolve the blue-purple crystals of formazan, and measure the absorbance value OD 570 , to analyze cell viabil...

Embodiment 3

[0081] Embodiment 3: reduce cellular inflammatory response

[0082] Macrophage RAW264.7 cells were treated with 2×10 4 Several kinds of cells were placed in 96-well cell culture dishes in 5% CO 2 , 37 ° C cell culture box after overnight culture, remove the cell culture medium, add different dilution ratios (1 / 1600, 1 / 800, 1 / 400, 1 / 200 and 1 / 100) of AMDS and control substances (blank control group) , positive control group Quercetin). The stimulant LPS (Lipopolysaccharide, 0.1 μg / mL) was added to culture for 24 hours, and the cell supernatant was collected for ELISA testing of TNF-α and IL-6 to detect the contents of TNF-α and IL-6. Cell viability was analyzed using the method described in Example 2.

[0083] It can be seen from the results that the AMDS dilution ratio of 1 / 200 and 1 / 100 will reduce the TNF-α content ( figure 2 ); the dilution ratio 1 / 1600, 1 / 800, 1 / 400, 1 / 200, 1 / 100 will reduce the IL-6 content ( image 3 ), with a statistically significant difference c...

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Abstract

The invention provides a nursing composition and application thereof. The care composition comprises stem and / or leaf extracts of sweet potatoes, yam beans and / or Chinese yams and an ionic solution, wherein the salinity of the care composition is that the sodium content is lower than 0.3% (w / w), and the magnesium content is that the potassium content is that the magnesium content is lower than 0.3% (w / w).

Description

technical field [0001] The invention discloses a nursing composition and its application, and particularly relates to the application of the nursing composition in preparing a medical composition for treating and regulating the number of secretory vesicles in goblet cells of the nasal cavity. Background technique [0002] In healthy people, glands in the nose, throat and airway mucous membranes (Mucosa) produce about 1 to 1.5 liters of a thick substance called mucus per day. The main purpose of mucus is to help capture and destroy harmful bacteria and viruses from the outside world, preventing them from entering the body. Mucus eventually enters the digestive system to be cleared or excreted through secretions, which are often imperceptible, similar to breathing or blinking. However, when infected by viruses and stimulated by irritants, these viruses, particles, and microorganisms increase mucus production, producing excess and thicker mucus. The increase in the amount and...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K36/8945A61K33/06A61K33/26A61K33/34A61K33/30A61K33/18A61K33/24A61K45/00A61P11/02A61P11/00
CPCA61K36/48A61K36/8945A61K33/06A61K33/26A61K33/34A61K33/30A61K33/18A61K33/24A61K45/00A61P11/02A61P11/00A61K2300/00
Inventor 苏珍仪
Owner 苏珍仪
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