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Low-cost preparation method of L-carnitine

A low-cost, carnitine-based technology, applied in the field of medicine, can solve the problems of increased production equipment, lack of market price competitiveness, high usage of biological enzymes, etc., to reduce the labor of production staff, shorten production time, and simplify synthesis steps Effect

Pending Publication Date: 2022-05-06
华今(山东)新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantage of this synthetic route is: avoiding the use of highly toxic sodium cyanide, and the disadvantages are: the preparation of biological enzymes used in the synthesis is complex, the activity of biological enzymes is sensitive to environmental influences, and the amount of biological enzymes used is high, the cost of producing L-carnitine is high, and there is no market price Competitiveness
Disadvantages are: synthesis preparation needs 4 steps to obtain L-carnitine, long synthesis time and increase of production equipment, high production cost

Method used

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  • Low-cost preparation method of L-carnitine
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  • Low-cost preparation method of L-carnitine

Examples

Experimental program
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Effect test

Embodiment 1

[0029] 1. Compound (Ⅲ) ethanol solution preparation

[0030]

[0031] Add 200 mL of absolute ethanol and S-epichlorohydrin (100 g, 1081 mmol) to a 1000 ml four-neck flask with a stirring thermometer after drying, and start stirring with benzyltriethylammonium chloride (3 g, 13.2 mmol). When the cold water bath cools down to 20°C, NaCN (55.6g, 1135mmol) is added in 5 times. After the addition is completed, the reaction is stirred at 20-30°C for 5h. The gas chromatography detects that the raw material S-epichlorohydrin has completely reacted, and the reaction is stopped. The filter cake was suction filtered and washed with a small amount of absolute ethanol, and the filtrate was: compound (I) ethanol solution.

[0032] 2. L-carnitine preparation:

[0033]

[0034] Add a 35% hydrochloric acid aqueous solution (338g, 3241mmol) into a 1000ml four-neck flask with a stirring thermometer and start stirring. , the temperature was raised to 40° C., and the ethanol solution of al...

Embodiment 2

[0038] Add 250mL of absolute ethanol and S-epichlorohydrin (110g, 1189mmol) to a 1500ml four-necked flask with a stirring thermometer after drying, and start stirring with benzyltriethylammonium chloride (5g, 21.9mmol). When the temperature in the cold water bath was lowered to 15°C, NaCN (64g, 1308mmol) was added in 5 times. After the addition was complete, the reaction was stirred at 20-30°C for 4h. The reaction of the raw material S-epichlorohydrin was detected by gas chromatography, and the reaction was stopped. Suction filter cake is washed with a small amount of absolute ethanol, and the filtrate is: ethanol solution of compound (I)

[0039] Add a 35% aqueous solution of hydrochloric acid (434g, 4161mmol) into a four-necked flask with a stirring thermometer, start stirring, and when the temperature is lowered to 15°C in a cold water bath, after the dropwise addition of a 33% aqueous solution of trimethylamine (255.5g, 1427mmol), Raise the temperature to 40°C and add drop...

Embodiment 3

[0042] Add 300mL of absolute ethanol and S-epichlorohydrin (150g, 1622mmol) to a 2000ml four-necked flask with a stirring thermometer after drying, and start stirring with benzyltriethylammonium chloride (7g, 30.7mmol). When the temperature in the cold water bath was lowered to 10°C, NaCN (119g, 2433mmol) was added in 5 times. After the addition was completed, the reaction was stirred at 20-30°C for 2h. The reaction of the raw material S-epichlorohydrin was detected by gas chromatography, and the reaction was stopped. The filter cake was suction filtered and washed with a small amount of absolute ethanol, and the filtrate was: ethanol solution of compound (I).

[0043] A concentration of 35% hydrochloric acid aqueous solution (676g, 6488mmol) was added in a four-neck flask with a stirring thermometer, and the stirring was started. Add all the ethanol solutions of compound (I) prepared above at 40°C dropwise, and react at 40-45°C for 3 hours after the dropwise addition, gas chr...

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Abstract

The invention relates to a low-cost preparation method of L-carnitine, which comprises the following steps: taking S-epichlorohydrin as an initial raw material, reacting with sodium cyanide to obtain a compound solution, directly carrying out ring opening and nitrile group hydrolysis reaction in trimethylamine and hydrochloric acid solution, and removing chloride ions through anion exchange resin to obtain the L-carnitine. The method is simple in synthesis steps and easy to operate, the synthesis steps of the L-carnitine are simplified, the production time is shortened, the labor of production staff is reduced, equipment in the production and synthesis process is reduced, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a low-cost preparation method of L-carnitine. Background technique [0002] L-carnitine, also known as L-carnitine, chemical name: (R)-3-hydroxy-4-(trimethylamino)butyrate. L-carnitine is a special amino acid that widely exists in human body tissues. It is considered as a "vitamin-like" nutrient. It has many clinical applications. Both cirrhosis and diabetes have curative or auxiliary therapeutic effects, and have been prescribed by the World Health Organization as a legal multi-purpose nutrient. In recent years, L-carnitine has also been widely used in the fields of nutrition and health care, weight loss and bodybuilding, enhancing sports ability, recovering from fatigue, food additives, and feed additives. Therefore, the market competitiveness is gradually intensified, and a low-cost preparation method is urgently needed to adapt to the current market competition...

Claims

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Application Information

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IPC IPC(8): C07C227/18C07C229/22
CPCC07C227/18C07C227/12C07D303/38C07B2200/09C07C229/22Y02P20/584
Inventor 陈文飞陈正栎
Owner 华今(山东)新材料科技有限公司
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