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Magnetic hydroxyl nano material Fe3O4 (at) COFs and application thereof in field of sulfanilamide mass spectrometry detection

A nanomaterial and hydroxyl technology, which is applied in the preparation of sulfonamide matrix-assisted laser desorption ionization mass spectrometry detection probes and the field of magnetic hydroxyl organic framework nanomaterials, achieves the advantages of good enrichment and ionization, good reproducibility, and good salt tolerance. Effect

Pending Publication Date: 2022-05-13
CHINA UNIV OF GEOSCIENCES (BEIJING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, Fe 3 o 4 The advantage of @COFs nanomaterials as a dual-functional platform for high-throughput screening of hazardous compounds in samples still needs to be further demonstrated. At the same time, using different monomers, designing and developing simple synthesis methods for magnetized COFs to enrich low Abundance of target molecules remains a challenge, as seen, Fe 3 o 4 @COFs nanomaterials remain to be further explored in this new field of research

Method used

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  • Magnetic hydroxyl nano material Fe3O4 (at) COFs and application thereof in field of sulfanilamide mass spectrometry detection
  • Magnetic hydroxyl nano material Fe3O4 (at) COFs and application thereof in field of sulfanilamide mass spectrometry detection
  • Magnetic hydroxyl nano material Fe3O4 (at) COFs and application thereof in field of sulfanilamide mass spectrometry detection

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1 Fe 3 o 4 Synthesis of @COFs

[0031] Take Fe respectively 3 o 4 (100mg, synthesized according to existing literature reports), TAPB (0.04mmol) and DHTP (0.06mmol) were put into a 50mL single-necked bottle, and then 5mL of acetonitrile was added. In order to fully mix and disperse the above substances, the above mixture was sonicated for 1min; then 0.4mL Acetic acid (12M), shake the mixture well, and react at room temperature for 72h; collect the brownish-yellow solid obtained, wash by 25mL methanol, and centrifuge at 8000rpm / min for 10 minutes, wash and centrifuge three times, and vacuum-dry overnight at room temperature , that is.

Embodiment 2

[0032] Example 2 Fe 3 o 4 Synthesis of @COFs

[0033] Take Fe respectively 3 o 4 (75mg, synthesized according to existing literature reports), TAPB (0.04mmol) and DHTP (0.06mmol) were put into a 50mL single-necked bottle, and then 5mL of acetonitrile was added. In order to fully mix and disperse the above substances, the above mixture was sonicated for 1min; then 0.4mL Acetic acid (12M), shake the mixture well, and react at room temperature for 72h; collect the brownish-yellow solid obtained, wash by 25mL methanol, and centrifuge at 8000rpm / min for 10 minutes, wash and centrifuge three times, and vacuum-dry overnight at room temperature , that is.

Embodiment 3

[0034] Example 3 Fe 3 o 4 Synthesis of @COFs

[0035] Take Fe respectively 3 o 4 (50mg, synthesized according to existing literature reports), TAPB (0.04mmol) and DHTP (0.06mmol) were put into a 50mL single-necked bottle, and then 5mL of acetonitrile was added. In order to fully mix and disperse the above substances, the above mixture was sonicated for 1min; then 0.4mL Acetic acid (12M), shake the mixture well, and react at room temperature for 72h; collect the brownish-yellow solid obtained, wash by 25mL methanol, and centrifuge at 8000rpm / min for 10 minutes, wash and centrifuge three times, and vacuum-dry overnight at room temperature , that is.

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Abstract

The invention belongs to the technical field of magnetic adsorption materials, particularly relates to a magnetic hydroxyl nano material Fe3O4 (at) COFs, and further discloses application of the magnetic hydroxyl nano material Fe3O4 (at) COFs to preparation of a sulfanilamide mass spectrometry detection probe. According to the magnetic hydroxyl nano material Fe3O4 (at) COFs, monodisperse Fe3O4 nano particles serve as a core, TAPB and DHTP serve as monomers, and hydroxyl-rich magnetic covalent organic framework nanospheres of a core-shell structure are rapidly synthesized at the room temperature. The Fe3O4-coated COFs nano material has the advantages of average pore size distribution, high magnetization intensity, high specific surface area, good chemical stability, optical absorptivity and the like, rich hydroxyl groups of the Fe3O4-coated COFs nano material and amino groups of sulfonamide antibiotic molecules can form hydrogen bonds, the surfaces of the COFs and benzene rings of sulfonamides form pi-pi conjugation acting force, rapid separation of samples can be achieved through magnetic nucleuses, and the magnetic nucleuses can be used for detecting the sulfonamide antibiotics. The MALDI matrix material is an adsorbent for rapidly enriching and separating sulfanilamide, is also used as a matrix for matrix-assisted laser desorption ionization mass spectrometry, has lower background interference when being used for measuring a sulfanilamide low-molecular target object, and can effectively absorb the energy of laser and promote ionization of the target object, so that the MALDI matrix material becomes an ideal MALDI matrix material.

Description

technical field [0001] The invention belongs to the technical field of magnetic adsorption materials, in particular to a magnetic hydroxyl nanomaterial Fe 3 o 4 @COFs, more specifically about a core-shell structured magnetic OH-organic framework nanomaterial Fe 3 o 4 @COFs, and further discloses its use for the preparation of sulfonamide matrix-assisted laser desorption ionization mass spectrometry detection probes. Background technique [0002] Sulfonamide antibiotics are emerging organic pollutants in the water environment and food. The residues of sulfonamide antibiotics can lead to the production of antibiotic resistance genes in bacteria, thus posing a potential threat to human and ecosystem health. Typically, detection of sulfa antibiotics remains a challenge due to the complexity of the matrix of the environment (tap water, surface water, groundwater, and environmental wastewater) and biological samples (milk, pork, fish) and the low levels of sulfa antibiotics. c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/64G01N1/40C01G49/08B82Y30/00B82Y15/00
CPCG01N27/64G01N1/405G01N1/40C01G49/08B82Y30/00B82Y15/00C01P2004/03C01P2004/04C01P2002/85C01P2002/82C01P2006/17C01P2006/42C01P2002/89
Inventor 于翔赵燕芳张以河裴敬轩孙一博
Owner CHINA UNIV OF GEOSCIENCES (BEIJING)