53 results about "Sulfaclomide" patented technology

The invention relates to the technical field of industrial wastewater deep purification, and discloses an industrial wastewater deep purification system based on nano catalytic membrane separation, which comprises a pretreatment module, a catalytic degradation module, a membrane separation module, an intelligent control module and a regeneration maintenance module which are sequentially connected according to a treatment flow, the pretreatment module adjusts the water quality of inlet water to a range suitable for subsequent treatment through pH adjustment and suspended matter interception, that is, the pH is 2-11, and the turbidity is less than or equal to 50NTU; the catalytic degradation module is used for decomposing organic pollutants and mineralizing refractory substances under the excitation of ultraviolet / visible light by utilizing the photocatalytic characteristic of a nano catalytic membrane. The TiO2 / WO3 heterojunction nano catalytic membrane is adopted, so that deep oxidation of refractory pollutants such as phenol and sulfonamide antibiotics is realized, finally, the COD removal rate of 98.7% is achieved, and compared with a traditional photocatalytic process, the energy consumption is reduced by 54%.

The invention relates to the technical field of microbial treatment of antibiotic pollution, and discloses an antibiotic degrading bacterium with salt tolerance and capable of degrading sulfamethoxazole at low temperature and application, the strain degrades SMX in a wide temperature range of 10-40 DEG C, the degradation rate of 20mg / L SMX at 10-35 DEG C within 64 hours is greater than 70%, and the degradation rate of 20mg / L SMX at 20-30 DEG C reaches 100%; at the low temperature of 10 DEG C, low-concentration SMX is obviously degraded, and the SMX with the concentration of 5 mg / L can be completely degraded within 16 hours; the MJ2 can still effectively degrade SMX under the harsh conditions that the temperature is low and SMX serves as the unique carbon and nitrogen source, the degradation rate reaches 100% after 66h at the concentration of 5 mg / L, and it is proved that the MJ2 has the unique oligotrophic adaptability. Salinity tests show that the degradation rate of MJ2 to 20 mg / L SMX within 48 hours under the 0.1-2% NaCl concentration is 100%, the degradation rate is still kept at 50% even under the stress of 3% high salt, and remarkable salt tolerance is also shown. In conclusion, the strain MJ2 integrates wide temperature range adaptability, low-temperature high efficiency, oligotrophic tolerance and high salt stability, and has great application value in sulfonamide antibiotic pollution remediation in a complex environment.

The application discloses a kind of nano magnetic flocculants and its preparation method and application, belong to drinking water processing technical field, including the following steps: step S1, modified ferroferric oxide nanosphere is ultrasonically dispersed in ammonia alcohol solution, while stirring, slowly drop adding tetraethyl orthosilicate, continue stirring after drop, after centrifugal separation, wash, obtain silica coated ferroferric oxide nanoparticles;Step S2, phenylalanine modified chitosan is added into glacial acetic acid solution, after completely swelling and dissolving, add silica coated ferroferric oxide nanoparticles and ultrasonic treatment, under low pressure ultraviolet lamp, then with anhydrous ethanol wash purification, vacuum drying to constant weight, obtain nano magnetic flocculants;The method of the application is simple and easy to operate, the nano magnetic flocculants prepared can be quickly adsorbed to the surface of sulfonamide antibiotics, produce flocculation and can be magnetically separated, very suitable for trace sulfonamide antibiotics in drinking water source efficient removal.

The invention belongs to the technical field of biochar preparation, water treatment and new materials, and discloses a composite material for sulfonamide antibiotic treatment, a preparation method and application, and the preparation method comprises the following steps: preparing sludge biochar SBC; mnO2 coated OSBC is prepared; aminated PCA is prepared; pCA-MnO2 (at) OSBC is prepared; the preparation method comprises the following steps: cutting absorbent cotton, ultrasonically cleaning with deionized water, drying, dispersing PCA-MnO2 coated OSBC into a polyvinyl alcohol PVA solution, dipping the absorbent cotton, dropwise adding glutaraldehyde for crosslinking, curing, dipping into a PCA-MnO2 coated OSBC suspension, and carrying out freeze-drying heat treatment. The composite material disclosed by the invention has relatively stable physical properties and chemical properties, can be efficiently separated from an aqueous solution and recycled after being degraded, and can achieve a relatively good degradation effect in various typical real water bodies.

The present invention belongs to the field of biomedicine technology, and specifically relates to a combination drug combination and application for inhibiting the proliferation of NPM1 mutant leukemia cells. The combination drug combination includes RAS selective lethal molecule 3 and sulfonamide antibiotics; and anti-tumor small molecule drugs. The sulfonamide antibiotics include sulfasalazine; the anti-tumor small molecule drugs are selected from one or more of cytarabine, daunorubicin and venetoclax. The present invention also provides the application of the pharmaceutical composition in the combination drug combination in the preparation of an NPM1 mutant leukemia ferroptosis effect evaluation reagent.

The application discloses a method for efficiently removing sulfonamide antibiotics by flocculent sludge domestication, and belongs to the technical field of sewage treatment. The method greatly improves the removal rate of sulfonamide antibiotics by adjusting the culture conditions of activated sludge in a traditional activated sludge system. The method can effectively remove antibiotics, has the characteristics of simple operation, low treatment cost and large-scale operation, and the removal of pollutants is mainly realized by sludge adsorption and microbial degradation. The important functional bacteria, nitrifying bacteria, in the activated sludge treatment process can improve the removal efficiency of antibiotics including antibiotic drugs through co-metabolism while completing nitrification, so that the functional bacteria can be enriched by inoculating activated sludge and domesticating the sludge into flocculent form, and the functional bacteria are used to efficiently remove sulfonamide antibiotics.

The present invention provides a method for the efficient mineralization of organic pollutants by series electrochemical method, which belongs to the field of water treatment technology. 1 O2+SO4 ·– ‑TRS system, the system adopts a two-electrode DC power supply, and sequentially includes a singlet oxygen degradation system and a sulfate radical degradation system; the singlet oxygen degradation system uses a Fe / CNT electrode as a cathode and a Ti4O7 as an anode; the sulfate radical degradation system uses a Fe / CA electrode as a cathode and a Ti4O7 as an anode. 1 O2) and sulfate radicals (SO4 ·‑ ) 1 O2+SO4 ·– The TRS system can achieve 90-100% mineralization of sulfonamide antibiotics (SAs) within 30 minutes, which is much higher than that of the single 1 O2 / HO · / SO4 ·– ‑AOP system.

The invention discloses a copper-zinc double-active metal site adsorbent with atom dispersion, a preparation method thereof and application of the copper-zinc double-active metal site adsorbent in adsorption of sulfonamide antibiotics. The preparation method comprises the following steps: carrying out solvothermal reaction on a methanol solution containing copper acetylacetonate, zinc acetate and 2-methylimidazole in a mass ratio of (0.12-0.24): (0.8-0.9): (1.3-1.4), taking a solid after the reaction is ended, washing, drying, and calcining in an inert atmosphere to obtain the copper-zinc double-active metal site adsorbent with atom dispersion. The adsorbent has the following prominent advantages that copper and zinc are anchored to a nitrogen-rich carbon skeleton in a monatomic form, copper and copper diatoms exist on the surface, and the utilization rate is high; the synergistic effect of the nitrogen-doped carbon matrix and active sites of copper and zinc endows the material with an adjustable electronic structure; the porous carbon structure provides a stable anchoring point for metal atoms, metal dissolution is effectively inhibited, and secondary pollution is avoided.

The invention discloses a preparation method of a sulfonamide antibiotic efficient adsorbent, which comprises the following steps: adding tetrabenzyl phosphate, a cross-linking agent, an auxiliary agent and a catalyst into a solvent according to a certain proportion, and carrying out Friedel-Crafts alkylation reaction at a certain temperature to obtain a product; and purifying the product to obtain the porous adsorbent. The prepared efficient adsorbent for the sulfonamide antibiotics has a relatively high specific surface area and a hierarchical pore structure, contains rich oxygen and phosphorus elements, has relatively high adsorption capacity on various sulfonamide antibiotics, is relatively high in adsorption rate, and can be regenerated and recycled through regeneration treatment. The efficient adsorbent for the sulfonamide antibiotics, provided by the invention, is simple in preparation method and relatively low in cost, can be used for quickly and efficiently treating sewage containing the sulfonamide antibiotics, and has wide popularization and application prospects.

The invention discloses a method for synthesizing a single-atom cobalt catalyst by pyrolysis of a ligand-assisted supramolecular strategy and the resulting catalyst and application, and belongs to the field of water pollution control technology. The method provided by the present invention comprises the following steps: cobalt phthalocyanine and trimesic acid are mixed in water to obtain a cobalt phthalocyanine trimesic acid complex solution; then a dicyandiamide aqueous solution is added, and after stirring, an N-allylthiourea aqueous solution is added, and after the stirring reaction, the solid product obtained is washed and dried, and then pyrolysis is performed at high temperature, and the pyrolysis product is acid-leached and washed, and a single-atom cobalt catalyst is obtained after drying. The method of the present invention can obtain a single-atom cobalt catalyst with a high cobalt loading, and at the same time, it can achieve efficient degradation of sulfonamide antibiotics in sewage, and the removal rate of sulfonamide antibiotics can be made to reach more than 90% within 2 minutes, and the antibiotic removal rate within 5 minutes reaches more than 98%, and after multiple recycling, very high catalytic efficiency can still be maintained.

The invention relates to a method for analyzing pollutants in hospital wastewater based on liquid chromatography-high resolution mass spectrometry. The method comprises the following steps: S1, enriching pollutants in hospital wastewater through solid-phase extraction of four specific solid-phase extraction columns, and then analyzing and detecting a liquid to be detected through a specific chromatographic column, a specific liquid chromatography and a high-resolution mass spectrometry which are connected in series; the identification of various pollutants (medicines and metabolites thereof) in the hospital wastewater is realized, so that a data basis is provided for subsequent fingerprint analysis. Specifically, the analysis method provided by the invention can identify 34 kinds of substances, including sulfonamide antibiotics, macrolide antibiotics, cephalosporin antibiotics, quinolone antibiotics, beta-lactam antibiotics, aminoglycoside antibiotics and carbamazepine and metabolites thereof.

The purpose of the present invention is to provide a compound that has an excellent effect of inducing BRD4 protein degradation and is useful as a cancer therapeutic agent, or a pharmaceutically acceptable salt thereof. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, each symbol is as defined in the description.]

The invention discloses preparation of a copper-based biomass composite catalyst and activation of PMS to degrade sulfonamide antibiotics in a water body, and belongs to the field of environmental engineering water treatment. The glutaraldehyde is used as a cross-linking agent, and the material and a chelate formed by metal ions form a fixed space structure, so that the problem of dissolution of the metal ions in the catalysis process is solved. Biomass gelatin and chitosan are used as raw materials to firstly prepare biomass composite microspheres, then the copper-based biomass composite catalyst is obtained through impregnation and crosslinking, and the copper-based biomass composite catalyst is used for activating PMS to degrade sulfonamide antibiotics in a water body. According to the present invention, the reaction conditions of the catalyst are simple, the green degradable material is used, the prepared catalyst is easy to store, the dissolution problem of copper ions during the catalysis process is effectively solved by introducing the cross-linking agent, and the sulfonamide antibiotics show the excellent removal performance.

The invention discloses a sulfanilamide drug-resistant gene standard substance as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) gene synthesis and clone construction; (2) preparing plasmid DNA (deoxyribonucleic acid); (3) DNA standard substance identification, subpackaging and storage; and (4) determining the value of the standard substance. According to the method, two valuing methods with different principles are adopted, a multi-step standard substance candidate purification method is developed by researching factors influencing the consistency of quantitative results between the two valuing methods, and impurities influencing the valuing results are removed. By optimizing preparation and valuing of the standard substance, equivalence and consistency of two valuing methods with different principles are achieved, and the problem that valuing can only be carried out through cooperation of multiple laboratories is solved.

The invention provides an incubation-free composite SERS (Surface Enhanced Raman Scattering) substrate as well as a preparation method and application thereof. The preparation method comprises the following steps: providing Ag nanoparticles; providing a nano carbon material, and loading the Ag nanoparticles on the surface of the nano carbon material to form an SERS solution system with a composite nano structure; loading a cationic polyelectrolyte structure on the surface of the nanofiber membrane to obtain a composite fiber membrane; the SERS solution system is dripped onto the composite fiber membrane, and the incubation-free composite SERS substrate is obtained. The detection efficiency and sensitivity of the sulfonamide antibiotics can be remarkably improved, and the application prospect is wide.

The invention relates to application of naphthoquine or pharmaceutically acceptable salt in preparation of drugs for resisting drug-resistant bacteria and drugs for treating pneumonia, and the naphthoquine is an antibacterial drug for inhibiting reproduction of the drug-resistant bacteria or killing the drug-resistant bacteria. The technical problems that in the prior art, acinetobacter baumannii LAC-4 mainly generates drug resistance to sulfonamides, and the scheme for treating acinetobacter baumannii LAC-4 infection is very limited clinically are solved through the proposal of phenoquine or pharmaceutically acceptable salt.

The invention discloses a trimethoprim / polyacrylic resin solid dispersant as well as a preparation method and application thereof, and belongs to the technical field of veterinary drug preparations. The trimethoprim / polyacrylic resin solid dispersant comprises the following raw materials: trimethoprim and polyacrylic resin, wherein the mass ratio of the trimethoprim to the polyacrylic resin is 0.02 to 0.3; and dissolving the raw materials with an organic solvent, and dialyzing or evaporating to remove the solvent to prepare the trimethoprim / polyacrylic resin solid dispersant. The prepared solid dispersing agent is high in drug loading rate and good in stability, and the formed solid dispersing agent obviously improves the glass transition temperature of trimethoprim. Besides, the preparation method is convenient to operate, simple and easy to implement, and the obtained solid dispersing agent can be compounded with the sulfonamides antibacterial drugs to serve as a synergist of the sulfonamides antibacterial drugs, so that the antibacterial effect of the sulfonamides antibacterial drugs is improved.

The present invention discloses a method for enriching and separating sulfonamide antibiotics in drinking water or milk, comprising the following steps: sample processing: adding trichloroacetic acid solution to the sample, vortexing and then ultrasonically centrifuging, and collecting the supernatant; magnetic deep eutectic solvent synthesis: stirring choline chloride, phenol and ferric chloride at room temperature to form a magnetic deep eutectic solvent; magnetic deep eutectic solvent / salt two-phase aqueous system: adding the formed magnetic deep eutectic solvent to the supernatant, vortexing and oscillating, adding salt, vortexing and oscillating, to form a magnetic deep eutectic solvent / salt two-phase aqueous system; extraction: placing a magnet at the bottom of the solution to attract magnetic droplets, moving the magnet upward to achieve phase separation of the two-phase aqueous system, accurately measuring the volumes of the upper and lower phases, and using a high performance liquid chromatograph to determine the concentration of sulfonamide antibiotics in the lower inorganic salt phase. This method can efficiently separate and enrich sulfonamide antibiotics, and the selected solvent is non-toxic and pollution-free, providing a new idea for the separation and enrichment of trace sulfonamide antibiotics.

This invention discloses a method for the efficient degradation and deep mineralization of sulfonamide antibiotics in wastewater, relating to the field of wastewater treatment technology. The method includes the following steps: preparing a phosphate buffer solution and adding Na6TPP working solution, adding SAs working solution, adjusting the pH, adding iron filings and carbon fibers, injecting air, and reacting for 3 hours to obtain a reaction solution; taking sterilized nutrient solution containing SAs-containing anaerobic activated sludge; adding activated sludge to the sterile nutrient solution to prepare the reaction solution, sealing and shaking for incubation; allowing it to stand for seven days after degradation, repeating the preparation of sterile nutrient solution, continuing enrichment, and obtaining SAs-containing activated sludge; after removing iron from the reaction solution using anion exchange resin, adding trace elements and vitamins to prepare an anaerobic activated sludge nutrient solution; inoculating the acclimated SAs-containing activated sludge into the nutrient solution, shaking for incubation, and continuing to degrade the remaining organic matter after pre-oxidation. This invention deeply mineralizes SAs, thereby increasing the degradation rate of sulfonamide antibiotics and total organic carbon.

The invention relates to the technical field of food safety detection, and particularly provides an analysis method and system for detecting various antibiotic residues in edible parts of vegetables. According to the method, aiming at the problem that various antibiotics in vegetables are difficult to efficiently and accurately detect at the same time in the prior art, synchronous and efficient extraction and purification of sulfonamides, quinolones and tetracyclines antibiotics are realized by optimizing a sample pretreatment process; according to the method, specific ultra-high performance liquid chromatography-tandem high-resolution mass spectrometry analysis conditions are combined, intelligent comparison is performed by utilizing a pre-constructed standard compound database, and rapid screening and accurate quantification of various target antibiotics in the complex vegetable matrix are completed. The invention provides a set of complete solution, has the advantages of universal and efficient pretreatment, high detection flux, good accuracy and the like, and provides a reliable technical means for daily monitoring and risk assessment of antibiotic residues in vegetables.

The present invention belongs to the technical fields of biochar preparation, water treatment, and new materials, and discloses a composite material, a preparation method, and an application for the treatment of sulfonamide antibiotics, which include the following steps: preparing sludge biochar SBC; preparing MnO2@OSBC; preparing aminated PCA; preparing PCA-MnO2@OSBC; cutting degreased cotton, ultrasonically cleaning it with deionized water, drying it, dispersing PCA-MnO2@OSBC in a polyvinyl alcohol PVA solution, impregnating the degreased cotton, dropping glutaraldehyde for crosslinking, curing, immersing it in a PCA-MnO2@OSBC suspension, and freeze-drying and heat-treating. The composite material of the present invention has relatively stable physical and chemical properties, can achieve efficient separation and recycling from the aqueous solution after degradation, and can achieve good degradation effects in a variety of typical real water bodies.

The invention discloses an adsorption-oxidation difunctional boron-doped porous biochar material and a preparation method and application thereof, the preparation method comprises the following steps: mixing alfalfa, sodium bicarbonate, boric acid and water, evaporating and pyrolyzing to obtain the boron-doped porous biochar material. The adsorption-oxidation dual-function boron-doped porous biochar material has the advantages of large specific surface area, developed multi-stage pore structure, rich oxygen-containing functional groups, good surface affinity, high-reaction-activity boron-doped species BC3 and the like, so that the adsorption performance and the catalytic performance are excellent; when being applied to a persulfate advanced oxidation technology, the catalyst can realize efficient removal of sulfonamide antibiotics mediated by a non-free radical way, has the advantages of strong adsorption capacity, high catalytic activity, good recycling property and the like, and shows good practical application potential.

The invention discloses a pseudointermediate Brucella strain for degrading sulfonamide antibiotics, the pseudointermediate Brucella strain is preserved in the Guangdong Microbial Culture Collection Center, and the preservation number of the pseudointermediate Brucella strain is GDMCC No: 63617. The pseudointermediate Brucella strain can be used for degrading the sulfonamide antibiotics, and the pseudointermediate Brucella strain is preserved in the Guangdong Microbial Culture Collection Center. The invention also provides application of the Brucella pseudointermedius strain for degrading the sulfonamide antibiotics, and the strain has very strong degradation capability on the sulfonamide antibiotics in livestock and poultry wastes (especially livestock and poultry manure or compost thereof), and can simultaneously have very strong degradation capability on various sulfonamide antibiotics in the livestock and poultry manure or compost thereof; and the microbial agent has good compatibility with native microbial flora in livestock and poultry wastes (especially livestock and poultry manure or compost thereof), and has strong adaptability.

The application discloses a method for degrading sulfonamide antibiotics in wastewater by using goethite and Fe(II) salt. The specific steps include: dissolving Fe(II) salt, adding goethite, and fully adsorbing Fe(II) to goethite to prepare a goethite and Fe(II) mixture; anaerobically pretreating wastewater containing sulfonamide antibiotics, adding the goethite and Fe(II) mixture to a sulfonamide antibiotic wastewater treatment unit, carrying out anaerobic reaction, separating and discharging water, and starting the next cycle of treatment; on-line monitoring the oxidation-reduction potential of each reaction stage, controlling the start and end of the reaction by the oxidation-reduction potential, and supplementing Fe(II) again to restore the degradation performance when the degradation efficiency of the sulfonamide antibiotic decreases and is controlled by the oxidation-reduction potential. The method is mild, the materials are cheap and easy to obtain, and the method is environment-friendly, and the sulfonamide antibiotic can be directionally degraded; Fe(II) can be recycled, and the purpose of efficiently treating sulfonamide antibiotic wastewater is achieved.

This invention belongs to the field of sulfonamide antibiotic detection, specifically relating to a method for determining the content of sulfamethoxazole. The method includes the following steps: 1) Sulfamethoxazole standard and water are mixed and sonicated until dissolved to obtain a sulfamethoxazole stock solution with a concentration not exceeding 10 mg / L; standard solutions of different concentrations are prepared using the sulfamethoxazole stock solution and water, absorbance is measured, a standard curve is plotted, and a linear regression equation is obtained; 2) Sulfamethoxazole solid preparation is mixed with water, sonicated to aid dissolution, and filtered to prepare a test solution; or the water sample to be tested is filtered to prepare a test solution; the absorbance of the test solution is measured, and the content of sulfamethoxazole is determined according to the linear regression equation. This invention utilizes ultraviolet spectrophotometry, using water as a solvent, to determine the content of the active ingredient in sulfamethoxazole preparations or the concentration of sulfamethoxazole in environmental water samples. It offers high accuracy, significantly reduces testing costs, and shortens testing time.

The invention discloses a preparation method and application of a spherical nucleic acid-based nanoprobe and a paper-based chip thereof. The preparation method is characterized by comprising the following steps: preparing the spherical nucleic acid nanoprobe based on a sulfadiazine aptamer by adopting a microwave method; the paper-based chip is prepared by constructing a hydrophobic barrier by adopting a laser printing and high-temperature heating method, a to-be-detected water sample is dropwise added into a sample adding area of the paper-based chip, and the sample firstly reaches a detection area 1 through capillary action and is gathered after acting with a nano probe for detecting aminoglycoside antibiotics, so that the color of the paper-based chip is changed; after the sample continuously flows to a detection area 2 and reacts with the prepared spherical nucleic acid nanoprobe based on the sulfadiazine aptamer, a sodium chloride solution is dropwise added into the area to trigger a particle aggregation reaction, so that the color of the paper-based chip is changed, and simultaneous detection of aminoglycoside and sulfonamide antibiotics is realized. Compared with the prior art, the method has the characteristics of rapidness, convenience, economy and practicability, and is of great significance to environmental risk assessment, pollutant control and public health.

The invention discloses an immobilization method and application of a sulfonamide antibiotic degrading flora, and belongs to the technical field of sewage treatment. The chitosan modified filler is used as an immobilization carrier, and in the process of immobilizing the sulfonamide antibiotic degrading flora, the sulfonamide antibiotics, the specific carbon source and the specific nitrogen source are added, so that the immobilization process can be enhanced, the immobilization period can be shortened, and meanwhile, the biomass of the immobilized degrading flora can be improved; the sulfonamide antibiotic degrading flora can be better colonized, and the degradation rate of the immobilized sulfonamide antibiotic degrading flora filler to sulfonamide antibiotics is obviously improved; besides, the immobilized sulfonamide antibiotic degrading flora filler obtained by the immobilization method has the characteristics of quick response and long-term operation stability, can meet the emergency treatment requirements of sudden antibiotic pollution events, can also be used as a biological enhancement means to play a role, can be suitable for large-scale wastewater treatment engineering, and has a wide application prospect. The method has the advantages of high efficiency, economy and environmental protection.

This invention discloses a cubic bifunctional adsorbent material, its preparation method, and its applications. The preparation method includes the following steps: calcining a zeolite imidazole framework at a temperature above 800°C under an inert atmosphere to obtain the cubic bifunctional adsorbent material. The cubic bifunctional adsorbent material of this invention can simultaneously adsorb sulfonamide antibiotics and heavy metals. It also possesses a large specific surface area, numerous adsorption sites, abundant pore structure, large pore volume and diameter, and high adsorption capacity. It is a novel bifunctional adsorbent with excellent performance. When used to treat complex wastewater containing sulfonamide antibiotics and heavy metals, it can effectively remove these substances from the wastewater, demonstrating high practical value and promising application prospects. The preparation method of this invention also has advantages such as simple process, convenient operation, low cost, economic safety, and ease of promotion. It plays a significant role in promoting the large-scale preparation and industrial application of cubic bifunctional adsorbent materials.

The application discloses a method for detecting sulfonamide antibiotics in water environment by using ultra-high performance liquid chromatography tandem mass spectrometry, which comprises the following steps: (1) sampling; (2) dispersive solid phase extraction; (3) concentration and constant volume; (4) ultra-high performance liquid chromatography-tandem mass spectrometry detection; (5) drawing a standard curve; (6) according to the ion flow chromatogram of the sulfonamide antibiotics in the solution in the step (4), the type of the detected sulfonamide antibiotics is identified and determined, the quantitative ion integral peak area ratio of each sulfonamide antibiotic and the corresponding isotopic internal standard is obtained, the ratio is compared with the corresponding standard curve, and finally the actual concentration of the sulfonamide antibiotics in the sample can be obtained through conversion. The application has the advantages of simple operation, fast sample pretreatment, accurate detection result, high sensitivity, satisfactory recovery rate and reproducibility, and can be used for the content determination of the sulfonamide antibiotics in different matrix water environments such as fresh water and seawater.