30 results about "Sulfaclomide" patented technology

The invention relates to the technical field of microbial treatment of antibiotic pollution, and discloses an antibiotic degrading bacterium with salt tolerance and capable of degrading sulfamethoxazole at low temperature and application, the strain degrades SMX in a wide temperature range of 10-40 DEG C, the degradation rate of 20mg / L SMX at 10-35 DEG C within 64 hours is greater than 70%, and the degradation rate of 20mg / L SMX at 20-30 DEG C reaches 100%; at the low temperature of 10 DEG C, low-concentration SMX is obviously degraded, and the SMX with the concentration of 5 mg / L can be completely degraded within 16 hours; the MJ2 can still effectively degrade SMX under the harsh conditions that the temperature is low and SMX serves as the unique carbon and nitrogen source, the degradation rate reaches 100% after 66h at the concentration of 5 mg / L, and it is proved that the MJ2 has the unique oligotrophic adaptability. Salinity tests show that the degradation rate of MJ2 to 20 mg / L SMX within 48 hours under the 0.1-2% NaCl concentration is 100%, the degradation rate is still kept at 50% even under the stress of 3% high salt, and remarkable salt tolerance is also shown. In conclusion, the strain MJ2 integrates wide temperature range adaptability, low-temperature high efficiency, oligotrophic tolerance and high salt stability, and has great application value in sulfonamide antibiotic pollution remediation in a complex environment.

The application discloses a kind of nano magnetic flocculants and its preparation method and application, belong to drinking water processing technical field, including the following steps: step S1, modified ferroferric oxide nanosphere is ultrasonically dispersed in ammonia alcohol solution, while stirring, slowly drop adding tetraethyl orthosilicate, continue stirring after drop, after centrifugal separation, wash, obtain silica coated ferroferric oxide nanoparticles;Step S2, phenylalanine modified chitosan is added into glacial acetic acid solution, after completely swelling and dissolving, add silica coated ferroferric oxide nanoparticles and ultrasonic treatment, under low pressure ultraviolet lamp, then with anhydrous ethanol wash purification, vacuum drying to constant weight, obtain nano magnetic flocculants;The method of the application is simple and easy to operate, the nano magnetic flocculants prepared can be quickly adsorbed to the surface of sulfonamide antibiotics, produce flocculation and can be magnetically separated, very suitable for trace sulfonamide antibiotics in drinking water source efficient removal.

The application discloses a method for efficiently removing sulfonamide antibiotics by flocculent sludge domestication, and belongs to the technical field of sewage treatment. The method greatly improves the removal rate of sulfonamide antibiotics by adjusting the culture conditions of activated sludge in a traditional activated sludge system. The method can effectively remove antibiotics, has the characteristics of simple operation, low treatment cost and large-scale operation, and the removal of pollutants is mainly realized by sludge adsorption and microbial degradation. The important functional bacteria, nitrifying bacteria, in the activated sludge treatment process can improve the removal efficiency of antibiotics including antibiotic drugs through co-metabolism while completing nitrification, so that the functional bacteria can be enriched by inoculating activated sludge and domesticating the sludge into flocculent form, and the functional bacteria are used to efficiently remove sulfonamide antibiotics.

The invention discloses a copper-zinc double-active metal site adsorbent with atom dispersion, a preparation method thereof and application of the copper-zinc double-active metal site adsorbent in adsorption of sulfonamide antibiotics. The preparation method comprises the following steps: carrying out solvothermal reaction on a methanol solution containing copper acetylacetonate, zinc acetate and 2-methylimidazole in a mass ratio of (0.12-0.24): (0.8-0.9): (1.3-1.4), taking a solid after the reaction is ended, washing, drying, and calcining in an inert atmosphere to obtain the copper-zinc double-active metal site adsorbent with atom dispersion. The adsorbent has the following prominent advantages that copper and zinc are anchored to a nitrogen-rich carbon skeleton in a monatomic form, copper and copper diatoms exist on the surface, and the utilization rate is high; the synergistic effect of the nitrogen-doped carbon matrix and active sites of copper and zinc endows the material with an adjustable electronic structure; the porous carbon structure provides a stable anchoring point for metal atoms, metal dissolution is effectively inhibited, and secondary pollution is avoided.

The invention relates to a method for analyzing pollutants in hospital wastewater based on liquid chromatography-high resolution mass spectrometry. The method comprises the following steps: S1, enriching pollutants in hospital wastewater through solid-phase extraction of four specific solid-phase extraction columns, and then analyzing and detecting a liquid to be detected through a specific chromatographic column, a specific liquid chromatography and a high-resolution mass spectrometry which are connected in series; the identification of various pollutants (medicines and metabolites thereof) in the hospital wastewater is realized, so that a data basis is provided for subsequent fingerprint analysis. Specifically, the analysis method provided by the invention can identify 34 kinds of substances, including sulfonamide antibiotics, macrolide antibiotics, cephalosporin antibiotics, quinolone antibiotics, beta-lactam antibiotics, aminoglycoside antibiotics and carbamazepine and metabolites thereof.

The purpose of the present invention is to provide a compound that has an excellent effect of inducing BRD4 protein degradation and is useful as a cancer therapeutic agent, or a pharmaceutically acceptable salt thereof. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, each symbol is as defined in the description.]

The invention discloses preparation of a copper-based biomass composite catalyst and activation of PMS to degrade sulfonamide antibiotics in a water body, and belongs to the field of environmental engineering water treatment. The glutaraldehyde is used as a cross-linking agent, and the material and a chelate formed by metal ions form a fixed space structure, so that the problem of dissolution of the metal ions in the catalysis process is solved. Biomass gelatin and chitosan are used as raw materials to firstly prepare biomass composite microspheres, then the copper-based biomass composite catalyst is obtained through impregnation and crosslinking, and the copper-based biomass composite catalyst is used for activating PMS to degrade sulfonamide antibiotics in a water body. According to the present invention, the reaction conditions of the catalyst are simple, the green degradable material is used, the prepared catalyst is easy to store, the dissolution problem of copper ions during the catalysis process is effectively solved by introducing the cross-linking agent, and the sulfonamide antibiotics show the excellent removal performance.

The invention discloses a sulfanilamide drug-resistant gene standard substance as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) gene synthesis and clone construction; (2) preparing plasmid DNA (deoxyribonucleic acid); (3) DNA standard substance identification, subpackaging and storage; and (4) determining the value of the standard substance. According to the method, two valuing methods with different principles are adopted, a multi-step standard substance candidate purification method is developed by researching factors influencing the consistency of quantitative results between the two valuing methods, and impurities influencing the valuing results are removed. By optimizing preparation and valuing of the standard substance, equivalence and consistency of two valuing methods with different principles are achieved, and the problem that valuing can only be carried out through cooperation of multiple laboratories is solved.

The invention provides an incubation-free composite SERS (Surface Enhanced Raman Scattering) substrate as well as a preparation method and application thereof. The preparation method comprises the following steps: providing Ag nanoparticles; providing a nano carbon material, and loading the Ag nanoparticles on the surface of the nano carbon material to form an SERS solution system with a composite nano structure; loading a cationic polyelectrolyte structure on the surface of the nanofiber membrane to obtain a composite fiber membrane; the SERS solution system is dripped onto the composite fiber membrane, and the incubation-free composite SERS substrate is obtained. The detection efficiency and sensitivity of the sulfonamide antibiotics can be remarkably improved, and the application prospect is wide.

This invention discloses a method for the efficient degradation and deep mineralization of sulfonamide antibiotics in wastewater, relating to the field of wastewater treatment technology. The method includes the following steps: preparing a phosphate buffer solution and adding Na6TPP working solution, adding SAs working solution, adjusting the pH, adding iron filings and carbon fibers, injecting air, and reacting for 3 hours to obtain a reaction solution; taking sterilized nutrient solution containing SAs-containing anaerobic activated sludge; adding activated sludge to the sterile nutrient solution to prepare the reaction solution, sealing and shaking for incubation; allowing it to stand for seven days after degradation, repeating the preparation of sterile nutrient solution, continuing enrichment, and obtaining SAs-containing activated sludge; after removing iron from the reaction solution using anion exchange resin, adding trace elements and vitamins to prepare an anaerobic activated sludge nutrient solution; inoculating the acclimated SAs-containing activated sludge into the nutrient solution, shaking for incubation, and continuing to degrade the remaining organic matter after pre-oxidation. This invention deeply mineralizes SAs, thereby increasing the degradation rate of sulfonamide antibiotics and total organic carbon.

The invention relates to the technical field of food safety detection, and particularly provides an analysis method and system for detecting various antibiotic residues in edible parts of vegetables. According to the method, aiming at the problem that various antibiotics in vegetables are difficult to efficiently and accurately detect at the same time in the prior art, synchronous and efficient extraction and purification of sulfonamides, quinolones and tetracyclines antibiotics are realized by optimizing a sample pretreatment process; according to the method, specific ultra-high performance liquid chromatography-tandem high-resolution mass spectrometry analysis conditions are combined, intelligent comparison is performed by utilizing a pre-constructed standard compound database, and rapid screening and accurate quantification of various target antibiotics in the complex vegetable matrix are completed. The invention provides a set of complete solution, has the advantages of universal and efficient pretreatment, high detection flux, good accuracy and the like, and provides a reliable technical means for daily monitoring and risk assessment of antibiotic residues in vegetables.

The invention discloses a pseudointermediate Brucella strain for degrading sulfonamide antibiotics, the pseudointermediate Brucella strain is preserved in the Guangdong Microbial Culture Collection Center, and the preservation number of the pseudointermediate Brucella strain is GDMCC No: 63617. The pseudointermediate Brucella strain can be used for degrading the sulfonamide antibiotics, and the pseudointermediate Brucella strain is preserved in the Guangdong Microbial Culture Collection Center. The invention also provides application of the Brucella pseudointermedius strain for degrading the sulfonamide antibiotics, and the strain has very strong degradation capability on the sulfonamide antibiotics in livestock and poultry wastes (especially livestock and poultry manure or compost thereof), and can simultaneously have very strong degradation capability on various sulfonamide antibiotics in the livestock and poultry manure or compost thereof; and the microbial agent has good compatibility with native microbial flora in livestock and poultry wastes (especially livestock and poultry manure or compost thereof), and has strong adaptability.

This invention belongs to the field of sulfonamide antibiotic detection, specifically relating to a method for determining the content of sulfamethoxazole. The method includes the following steps: 1) Sulfamethoxazole standard and water are mixed and sonicated until dissolved to obtain a sulfamethoxazole stock solution with a concentration not exceeding 10 mg / L; standard solutions of different concentrations are prepared using the sulfamethoxazole stock solution and water, absorbance is measured, a standard curve is plotted, and a linear regression equation is obtained; 2) Sulfamethoxazole solid preparation is mixed with water, sonicated to aid dissolution, and filtered to prepare a test solution; or the water sample to be tested is filtered to prepare a test solution; the absorbance of the test solution is measured, and the content of sulfamethoxazole is determined according to the linear regression equation. This invention utilizes ultraviolet spectrophotometry, using water as a solvent, to determine the content of the active ingredient in sulfamethoxazole preparations or the concentration of sulfamethoxazole in environmental water samples. It offers high accuracy, significantly reduces testing costs, and shortens testing time.

The invention discloses a preparation method and application of a spherical nucleic acid-based nanoprobe and a paper-based chip thereof. The preparation method is characterized by comprising the following steps: preparing the spherical nucleic acid nanoprobe based on a sulfadiazine aptamer by adopting a microwave method; the paper-based chip is prepared by constructing a hydrophobic barrier by adopting a laser printing and high-temperature heating method, a to-be-detected water sample is dropwise added into a sample adding area of the paper-based chip, and the sample firstly reaches a detection area 1 through capillary action and is gathered after acting with a nano probe for detecting aminoglycoside antibiotics, so that the color of the paper-based chip is changed; after the sample continuously flows to a detection area 2 and reacts with the prepared spherical nucleic acid nanoprobe based on the sulfadiazine aptamer, a sodium chloride solution is dropwise added into the area to trigger a particle aggregation reaction, so that the color of the paper-based chip is changed, and simultaneous detection of aminoglycoside and sulfonamide antibiotics is realized. Compared with the prior art, the method has the characteristics of rapidness, convenience, economy and practicability, and is of great significance to environmental risk assessment, pollutant control and public health.

The invention discloses an immobilization method and application of a sulfonamide antibiotic degrading flora, and belongs to the technical field of sewage treatment. The chitosan modified filler is used as an immobilization carrier, and in the process of immobilizing the sulfonamide antibiotic degrading flora, the sulfonamide antibiotics, the specific carbon source and the specific nitrogen source are added, so that the immobilization process can be enhanced, the immobilization period can be shortened, and meanwhile, the biomass of the immobilized degrading flora can be improved; the sulfonamide antibiotic degrading flora can be better colonized, and the degradation rate of the immobilized sulfonamide antibiotic degrading flora filler to sulfonamide antibiotics is obviously improved; besides, the immobilized sulfonamide antibiotic degrading flora filler obtained by the immobilization method has the characteristics of quick response and long-term operation stability, can meet the emergency treatment requirements of sudden antibiotic pollution events, can also be used as a biological enhancement means to play a role, can be suitable for large-scale wastewater treatment engineering, and has a wide application prospect. The method has the advantages of high efficiency, economy and environmental protection.

This invention discloses a cubic bifunctional adsorbent material, its preparation method, and its applications. The preparation method includes the following steps: calcining a zeolite imidazole framework at a temperature above 800°C under an inert atmosphere to obtain the cubic bifunctional adsorbent material. The cubic bifunctional adsorbent material of this invention can simultaneously adsorb sulfonamide antibiotics and heavy metals. It also possesses a large specific surface area, numerous adsorption sites, abundant pore structure, large pore volume and diameter, and high adsorption capacity. It is a novel bifunctional adsorbent with excellent performance. When used to treat complex wastewater containing sulfonamide antibiotics and heavy metals, it can effectively remove these substances from the wastewater, demonstrating high practical value and promising application prospects. The preparation method of this invention also has advantages such as simple process, convenient operation, low cost, economic safety, and ease of promotion. It plays a significant role in promoting the large-scale preparation and industrial application of cubic bifunctional adsorbent materials.

The application discloses a method for detecting sulfonamide antibiotics in water environment by using ultra-high performance liquid chromatography tandem mass spectrometry, which comprises the following steps: (1) sampling; (2) dispersive solid phase extraction; (3) concentration and constant volume; (4) ultra-high performance liquid chromatography-tandem mass spectrometry detection; (5) drawing a standard curve; (6) according to the ion flow chromatogram of the sulfonamide antibiotics in the solution in the step (4), the type of the detected sulfonamide antibiotics is identified and determined, the quantitative ion integral peak area ratio of each sulfonamide antibiotic and the corresponding isotopic internal standard is obtained, the ratio is compared with the corresponding standard curve, and finally the actual concentration of the sulfonamide antibiotics in the sample can be obtained through conversion. The application has the advantages of simple operation, fast sample pretreatment, accurate detection result, high sensitivity, satisfactory recovery rate and reproducibility, and can be used for the content determination of the sulfonamide antibiotics in different matrix water environments such as fresh water and seawater.

The application provides a novel piezoelectric catalytic activation method and application of ferrate, and belongs to the technical field of ferrate activation, which comprises the following steps: dissolving potassium ferrate in deionized water; then adding zinc stannate into the potassium ferrate solution; and finally, under the condition of ultrasonic, the piezoelectric property of zinc stannate is used to catalytically activate ferrate. The activation method of ferrate provided by the application can be used for the degradation of sulfonamide antibiotics in water, and the degradation efficiency is significantly better than that of ferrate alone, and the adaptability is strong, and stable activation effect can be shown in various anion environments, and more importantly, the novel activation method solves the problem that the stability and oxidizability of ferrate are incompatible, can react under neutral conditions, ensures the stability, and has the oxidizability at the same time, and is suitable for popularization and application in sewage treatment.

The application discloses a device for detecting carbon and nitrogen stable isotopes of sulfonamide antibiotic monomers, and belongs to the field of isotope detection. Based on the principle of high-temperature catalytic combustion and high-temperature reduction, sulfonamide antibiotic monomer compounds separated by liquid chromatography are introduced into a high-temperature oxidation furnace, sulfonamide compounds in the sample are converted into CO2, N2 and part of nitrogen oxides (NO X ), after dehydration by an electric refrigeration device and a chemical trap, NO X is reduced into N2 by a reduction furnace, and the device removes excess O2 in the gas path; an isotope mass spectrometer measures the isotope ratio of CO2 and N2 entering the mass spectrometer system in carbon and nitrogen modes, respectively, so as to realize the measurement of the C and N isotopes of sulfonamide antibiotic monomers. The device can be used for analyzing the source, conversion rule and degradation mechanism of sulfonamide antibiotics in the environment.

The invention discloses an automatic preparation process of sulfadoxine, and belongs to the technical field of preparation of sulfanilamide antibacterial agents, and the automatic preparation process of sulfadoxine comprises the following steps: preparing a ZnFe2O4 catalyst by using a sol-gel combustion method under the assistance of microwave irradiation co-treatment, and after the catalyst is prepared, weighing the following raw materials: 4-chloro-5, 5, 6, 7, 8-tetramethyl-1, 3-pentanedione, 4-chloro-5, 5, 6-tetramethyl-1, 3, 6-tetramethyl-1, 3, 6-tetramethyl-1, 3, 6 The preparation method comprises the following steps: putting 2, 6-dimethoxypyrimidine, sulfanilamide sodium, DMF (Dimethyl Formamide), triethylamine and a ZnFe2O4 catalyst into a reactor, reacting under a photocatalytic condition to obtain a reaction solution containing sulfadoxine, carrying out reduced pressure distillation on the reaction solution through a distiller to recover DMF, distilling, pumping the distillation residual liquid into a continuous flow crystallizer, crystallizing, and drying to obtain sulfadoxine. Through the mode, an efficient photocatalytic system is introduced, the reaction efficiency is improved, the reaction temperature is reduced, and the reaction time is shortened.

The present application relates to a kind of naphtholquinone or pharmaceutically acceptable salt in the application of drug-resistant bacteria-resistant drug and the preparation of drug for treating pneumonia, naphtholquinone is the antibacterial drug of inhibiting drug-resistant bacteria reproduction or killing drug-resistant bacteria, by the proposal of phenol quinoline or pharmaceutically acceptable salt to solve the technical problems existing in the prior art, to solve the technical problems existing in the prior art, bauman acinetobacter LAC-4 mainly produces drug resistance to sulfonamides, in clinic, the scheme for treating bauman acinetobacter LAC-4 infection is very limited.

The present invention relates to sulfamide derivatives of formula I, wherein the meaning of groups R1 and R2 is indicated in the description, for use to prevent and / or treat alcohol use disorder. The invention also relates to the administration of these derivatives in combination with other drugs and / or ligands. (I)

The invention discloses a microbial electrochemical method and device for removing sulfonamide compounds in wastewater and recovering nitrogen resources. The device comprises a pool body, and an anode chamber and a cathode chamber which are formed by separating the interior of the pool body through a cation exchange membrane; an anode is arranged in the anode chamber, and a cathode is arranged in the cathode chamber; the anode and the cathode are connected with a power supply for applying constant potential; the anode chamber is used for treating wastewater containing sulfanilamide compounds and nitrate under an anoxic or micro-aerobic condition; the cathode chamber is filled with a cathode solution containing NaCl and a phosphate buffer solution, and the cathode chamber can realize spontaneous alkali production and ammonia recovery. According to the method, while efficient degradation of sulfonamide compounds is enhanced, nitrate nitrogen is directionally converted into recoverable ammonium nitrogen, and finally the synergistic target of removal of pharmaceutical wastewater composite pollutants and recycling of nitrogen is achieved.

The application provides a method for degrading sulfamethoxazole in sewage, and relates to the technical field of water organic pollutant treatment. Under the action of light and an external current, a persalt is added to sewage containing sulfamethoxazole to degrade the sulfamethoxazole in the sewage. The persalt acts as an oxidant to degrade the sulfamethoxazole under the action of photoelectricity synergistic catalysis. The persalt as the oxidant can capture electrons under the action of photoelectricity catalytic activation, thereby activating active species, promoting the separation of electron-hole pairs, improving the photo-catalytic performance, and improving the degradation effect and the degradation rate of the sulfamethoxazole. The method has important practical significance and application value for efficiently removing sulfonamide antibiotic pollutants in the environment.

The application discloses application of a sulfanilamide derivative in preparation of a medicine for treating respiratory syncytial virus pneumonia, and belongs to the technical field of biological medicines. It is found for the first time that 3-(4-methoxyphenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfonylmethyl]alaninamide has significant anti-respiratory syncytial virus (RSV) activity, can effectively reduce the lung index of a mouse infected with RSV, improve the pathological lesion degree of a lung and a bronchus of the mouse, can significantly reduce the expression of the RSV virus load in lung tissue of the mouse, and has a clear treatment effect on mouse pneumonia caused by RSV. Not only is new application direction and experimental evidence provided for 3-(4-methoxyphenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfonylmethyl]alaninamide, but also a new and effective candidate medicine is provided for clinical treatment of respiratory syncytial virus pneumonia, and has important biological medicine application value.

The application provides a device and method for detecting antibiotics in aquaculture water, and belongs to the technical field of environmental pollutant detection.The device is characterized in that Fe3O4@GO magnetic nano adsorbent material is encapsulated in a microfluidic chip reaction chamber, and a magnetic sticker is used to realize the immobilization and replaceable design of the adsorbent; an electromagnetic oscillation module is integrated to drive the adsorbent to vibrate in the microchannel, so that the mass transfer and capture efficiency of antibiotics such as sulfonamides, quinolones and tetracyclines is significantly improved.The application innovatively provides an integrated process of "adsorption-elution-detection", the pretreatment time is shortened from hours to 10 minutes, the synchronous detection of ultra-trace multi-component antibiotics in 5-10 muL water samples at the level of 0.01-5 mu g / L is realized, the detection precision is significantly improved compared with traditional methods, the anti-matrix interference ability is strong, and the device is suitable for real-time online monitoring of multi-antibiotic residues in aquaculture environment.

The invention relates to a preparation method of a bimetallic carbon composite membrane for dynamic catalytic degradation of sulfonamide antibiotics and a method for degrading sulfathiazole in water by activating peroxymonosulfate, and belongs to the technical field of separation catalytic membranes. The invention aims to solve the technical problems of difficulty in powder catalyst recovery and difficulty in membrane pollution control at present. The method comprises the following steps: dispersing a Zn / Co-ZIF / corn straw derived carbon material into deionized water; fixing the PVDF base membrane on the filter element of the suction filtration device; transferring the homogeneous suspension to a suction filtration device for suction filtration to obtain a composite membrane; and carrying out vacuum drying on the composite film. The catalytic membrane is constructed through a vacuum filtration method, has efficient peroxymonosulfate activation performance and an excellent membrane separation function, and realizes rapid degradation and efficient removal of sulfonamide antibiotics in water. The method has important popularization value and wide industrialization prospect in the field of continuous flow wastewater advanced treatment and recycling.

This invention relates to the field of environmental treatment materials, and more particularly to a graphite composite electrode for antibiotic degradation, its preparation method, and its applications. The preparation method includes: firstly, constructing a micro / nanoporous structure on the surface of a graphite sheet through electrochemical etching; subsequently, in-situ loading of nickel-iron oxide composite nanoparticles onto the porous graphite surface using a liquid-phase reduction method to obtain the graphite composite electrode. The composite electrode provided by this invention features a large specific surface area, abundant active sites, excellent conductivity, and structural stability, which can significantly improve the electrocatalytic degradation efficiency of antibiotics. Experimental results show that this composite electrode exhibits excellent degradation performance for levofloxacin, tetracycline, metronidazole, and sulfonamide antibiotics, and also demonstrates good cycle stability and broad applicability. The preparation process of this invention is simple and low-cost, and it has promising prospects for industrial application.

The invention discloses ore chemical pure product magnetic biochar applied to antibiotic removal and a preparation method thereof. Comprising the following steps: S1, cleaning, drying and crushing a biomass raw material to prepare biomass raw material powder; s2, preparing an iron ore chemical pure product Fe3O4 or FeS2 solution, and performing ultrasonic dissolution to prepare a solution A; s3, adding biomass raw material powder into the solution A to prepare a solution B; s4, dipping and stirring the mixed solution B, drying and grinding to obtain a mixture precursor C; and S5, pyrolyzing the mixture precursor C in a protective gas environment at 800-1000 DEG C for 2-4 hours, cooling, grinding into powder, and sieving with a 100-200-mesh sieve to obtain the magnetic biochar. According to the method disclosed by the invention, secondary pollution is not generated while the cost is saved, the method is suitable for large-scale application, and the prepared magnetic biochar has a good adsorption and removal effect on sulfonamide antibiotics.