Multifunctional nanoparticle and preparation method and application thereof

Abstract

The invention relates to a multifunctional nanoparticle which comprises a polylactic acid-glycolic acid copolymer, a mast cell degranulation inhibitor, a magnetic resonance contrast agent, a photosensitizer and targeting ligand protein, the mast cell degranulation inhibitor, the magnetic resonance contrast agent and the photosensitizer are coated by the polylactic acid-glycolic acid copolymer or embedded in the polylactic acid-glycolic acid copolymer, and the outer surface of the polylactic acid-glycolic acid copolymer is provided with terminal carboxyl groups. The targeting ligand protein is covalently linked with a terminal carboxyl group outside the polylactic acid-glycolic acid copolymer. The multifunctional nanoparticles can be gathered at the thrombus part, can enhance the imaging capability of magnetic resonance and a photoacoustic instrument on thrombus, can realize the functions of assisting in analyzing thrombus components, identifying the disease degree and judging whether the thrombus is early thrombus or late thrombus, can inhibit thrombus formation, and cannot increase the bleeding risk of a patient.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a multifunctional nanoparticle and a preparation method and application thereof. Background technique [0002] Venous thrombosis is a common disease in clinical medicine, but traditional imaging techniques such as nuclear magnetic resonance cannot accurately diagnose whether a patient has a thrombus, nor can it distinguish whether the thrombus is an early or late thrombus, and it is impossible to analyze the components of the thrombus. [0003] In addition, for patients who need imaging to determine whether they have a thrombotic disorder, there is often a high risk of thrombosis, and it is necessary to prevent thrombosis even if they have not yet developed the disease. Although the commonly used drugs for preventing thrombosis in clinical practice, such as aspirin and clopidogrel, have a certain effect of preventing thrombosis, they change the coagulation-anticoagulation sys...

AI Technical Summary

Problems solved by technology

[0002] Venous thrombosis is a common disease in clinical medicine, but traditional imaging techniques such as MRI cannot accurately diagnose whether a patient has a thrombus, nor can it distinguish whether the thrombus is an early thrombus or a late thrombus, let alone analyze the components of a thrombus

[0003] In addition, for patients who need to use imaging to determine whether they have thrombosis, there is often a high risk of thrombosis, and it is necessary to prevent thrombosis even if they have not developed the disease

Although the currently commonly used antithrombotic drugs such as aspirin and clopidogrel have a certain effect on preventing thrombosis, they may change the patient's coagulation-anticoagulation system and increase the risk of bleeding

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