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Organic metal nanoparticle as well as preparation method and application thereof

A nanoparticle and organometallic technology, applied in the field of organometallic nanoparticles and their preparation, can solve problems such as unpublished reports, and achieve the effects of enhanced water solubility and stability, adjustable optical properties, and simple preparation.

Active Publication Date: 2022-06-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no published reports on the use of organometallics in the field of photothermal immunotherapy

Method used

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  • Organic metal nanoparticle as well as preparation method and application thereof
  • Organic metal nanoparticle as well as preparation method and application thereof
  • Organic metal nanoparticle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: Preparation of TTF-F4TCNQ nanoparticles

[0059] A preparation method of organometallic nanoparticles, comprising the following steps:

[0060] Combine 100 μL of electron donor (40 mM tetrathiafulvalene solution, obtained by dissolving tetrathiafulvalene (TTF) in tetrahydrofuran) with 100 μL of electron acceptor (40 mM 2,3,5,6-tetrafluoro-7, 7',8,8'-tetracyanodimethyl-p-benzoquinone solution, by adding 2,3,5,6-tetrafluoro-7,7',8,8'-tetracyanodimethyl-p-benzoquinone ( F4TCNQ) was dissolved in dimethyl sulfoxide) and mixed well, then 100 μL of surfactant (8mM Poloxamer 188 (F127) solution, obtained by dissolving Poloxamer 188 (F127) in tetrahydrofuran) was added) After mixing evenly, a mixed solution was obtained; the mixed solution was added dropwise to 4 mL of pure water under the condition of vigorous stirring (500 rpm), after stirring for 4 h, dialyzed with a 10 kDa dialysis bag, and dried to obtain organometallic (TTF-F4TCNQ) Nanoparticles. The specific...

Embodiment 2

[0062] This example is basically the same as Example 1, except that the electron donor in this example is 100 μL of 40 mM tetrathiafulvalene solution, and the electron acceptor is 10 μL of 40 mM 2,3,5,6-tetrafluoro-7 ,7',8,8'-tetracyanodimethyl-p-benzoquinone solution, i.e. electron donor: electron acceptor=1:0.1, finally obtained organometallic (TTF-F4TCNQ) nanoparticles;

[0063] This example is basically the same as Example 1, except that the electron donor in this example is 100 μL of 40 mM tetrathiafulvalene solution, and the electron acceptor is 1000 μL of 40 mM 2,3,5,6-tetrafluoro-7 ,7',8,8'-tetracyanodimethyl-p-benzoquinone solution, i.e. electron donor: electron acceptor=1:10, finally obtained organometallic (TTF-F4TCNQ) nanoparticles;

[0064] The TTF-F4TCNQ nanoparticles (electron donor and electron acceptor molar ratios were 1:1, 1:0.1, 1:10) prepared in Example 1 and Example 2 were respectively made into 50 μg / mL TTF-F4TCNQ nanoparticles. For the particle solutio...

Embodiment 3

[0066]Example 3: Preparation of Organometallic Nanoparticle Solution

[0067] The method for preparing organometallic nanoparticles in this example is basically the same as that in Example 1, except that the electron donor and electron acceptor used in this example are shown in Table 1 below:

[0068] Table 1:

[0069]

[0070]

[0071] It was found through experiments that the group A-E can obtain the organometallic (DBTTF-F4TCNQ, BETTF-F4TCNQ, TTF-TCNQ, DBTTF-TCNQ, BETTF-TCNQ) nanoparticles as described in Example 1.

[0072] Performance check:

[0073] The organometallic (TTF-F4TCNQ, DBTTF-F4TCNQ, BETTF-F4TCNQ, TTF-TCNQ, DBTTF-TCNQ, BETTF-TCNQ) nanoparticles prepared in Example 1 and Example 3 were analyzed by UV-Vis-NIR spectroscopy Characterized, the results are as image 3 shown.

[0074] from image 3 It can be seen that the ultraviolet absorption of organometallic nanoparticles with 7,7,8,8-tetracyano-p-quinodimethane (TCNQ) as the electron acceptor is mainl...

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Abstract

The invention discloses organic metal nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of photo-thermal immune anti-tumor medicines. The organic metal nanoparticle provided by the invention comprises an electron donor and an electron acceptor. By changing the combination mode of the electron donor and the electron acceptor, the organic metal nanoparticles are formed through coordination of the electron donor and the electron acceptor, the water solubility and the stability of the organic metal nanoparticles are enhanced through protection of the surfactant, the organic metal nanoparticles with different optical properties are obtained, and absorption even can reach a near-infrared second region. The organic metal nanoparticles can consume glutathione and cysteine of tumor cells, can destroy in-vivo redox balance, enhance generation of active oxygen and enhance photothermal therapy mediated immunogenic death, can promote aging of dendritic cells, enhance infiltration of T cells and further enhance immunotherapy activity, and can be used for treating tumor tumors. And obvious inhibition of in-situ tumors and far-end tumors is realized.

Description

technical field [0001] The invention belongs to the technical field of photothermal immune anti-tumor medicine, and particularly relates to an organic metal nanoparticle and a preparation method and application thereof. Background technique [0002] Photothermal immunotherapy is a novel tumor treatment modality that combines photothermal therapy and immunotherapy, in which photothermal reagents with good light absorption properties generate thermal energy under the irradiation of specific wavelengths of laser light, locally increase tumor temperature, and lead to tumor cell immunogens. Sexual death; tumor-associated antigens produced by photothermal therapy can be combined with immune reagents to activate the body's immune function and enhance the effect of immunotherapy. However, the efficacy of current photothermal immunotherapy is mainly limited by the limited immunogenicity of tumor cells and their low immune response. The development of multifunctional photothermal age...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/10A61K49/22A61P35/00A61P35/04A61P37/04B82Y5/00
CPCA61K41/0052A61K47/10A61P35/00A61P35/04A61P37/04A61K49/225B82Y5/00Y02A50/30
Inventor 朱伟陈韵
Owner SOUTH CHINA UNIV OF TECH
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