The invention provides a method for production of 2, 6-dimethyl-4-tert-butylacetophenone with a tubular reactor. The method includes the steps of: S1, preparing an aluminum
chloride ethanol solution,adding
alumina and isopropanol to obtain a mixture A, conducting
ultrasonic dispersion on cobaltosic
oxide,
nickel powder, 2-chloro-5-nitropyridine, 4-nitropyrazole,
tetrathiafulvalene and
anhydrous ethanol, adding a mixture A and then performing treatment to obtain a catalyst; S2, mixing
dichloroethane with the catalyst to obtain a mixture B; S3, subjecting the mixture B,
acetyl chloride and 1, 3-dimethyl-5-tert-butylbenzene to
acylation reaction in a tubular reactor, and discharging the reaction liquid from an upper
discharge hole; and S4, centrifuging the reaction liquid, and respectively treating the supernatant and
filter cake, thus obtaining the recovered catalyst and 2, 6-dimethyl-4-tert-butylacetophenone. The method provided by the invention utilizes the tubular reactor for
continuous production, and has the advantages of simple operation, short time, few three industrial wastes, few by-product and high yield.