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Optical sensor for multi-mode detection of hydrogen peroxide as well as preparation method and application of optical sensor

An optical sensor, hydrogen peroxide technology, applied in the field of analysis and detection, can solve the problems of single signal analysis, interference, etc., and achieve the effect of expanding the range and high sensitivity detection

Pending Publication Date: 2022-06-24
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, current optical sensors mainly rely on single-signal analysis and are susceptible to interference from certain substances

Method used

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  • Optical sensor for multi-mode detection of hydrogen peroxide as well as preparation method and application of optical sensor
  • Optical sensor for multi-mode detection of hydrogen peroxide as well as preparation method and application of optical sensor
  • Optical sensor for multi-mode detection of hydrogen peroxide as well as preparation method and application of optical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Preparation and characterization of UAA@ZIF-8-NiSx optical sensor

[0061] Step 1: Preparation of silver nanoparticles (AgNPs)

[0062] The synthesis of Ag NPs mainly refers to the reported method. First, 0.1 mmol / L AgNO was prepared. 3 solution, additionally in 100 mL of NH 2 3.3 mL of NaOH (0.1 mol / L) was added to the OH·HCl (0.1 mmol / L) solution and mixed uniformly, and then 9 mL of the above mixed solution was added to the centrifuge tube. Without stirring, add 1 mL of AgNO to the centrifuge tube at a flow rate of 0.67 mL / s 3 . Finally, the centrifuge tube was inverted once to complete mixing to obtain a gray-green solution, which was stored at 4°C in the dark.

[0063] Step 2: Preparation of sea urchin-like nano-alloy particles (UAA-NCs)

[0064] Reference Adv Mater 26(15)(2014) 2431-9. Methods disclosed. First, add 4.8mL of HAuCl to a 25mL flask 4 The solution (0.01 mol / L) and 8.6 mL of ultrapure water were mixed uniformly, magnetically stirred (...

Embodiment 2

[0070] Example 2: SERS performance of UAA@ZIF-8-NiSx optical sensor

[0071] UAA@ZIF-8-NiSx optical sensor is a novel MOF-based SERS substrate. Due to the unique structure and properties of MOF, it endows the substrate with excellent properties and improves the sensing properties of traditional SERS substrates, such as chemical enhancement ability and molecular enrichment. ability. Furthermore, this novel SERS substrate has excellent Raman enhancement capability due to the enhanced Raman "hot spots" due to the etching of chiral materials. like figure 2 As shown in a and b, under the same conditions, the OPD is at 641cm -1 The Raman signal is 3 times higher than that of single unencapsulated UAAA-NPs.

[0072] Since the Raman reporter OPD is encapsulated in the structure of MOF and chiral nanomaterials, it can generate Raman signals with good repeatability and high stability. The time-dependent Raman spectra such as figure 2 shown in c. UAA@ZIF-8-NiSx nanomaterial at 641...

Embodiment 3

[0073] Example 3: Verification of Feasibility of Detection Strategy of UAA@ZIF-8-NiSx Optical Sensor

[0074] The first step is to prepare monodisperse chiral nanomaterials NiSx-L: The preparation of NiSx-NPs 2 (0.2mol / L) aqueous solution was added with 0.1mL L-Pen or D-Pen (0.2mol / L) aqueous solution, and then 0.1mL NaOH (0.2mol / L) aqueous solution was added dropwise, and the reaction was carried out by magnetic stirring for 1 hour to obtain dispersion. solution of NiSx-NPs.

[0075] The TEM image of NiSx-L is shown in 3, and the detection results show that it has strong circular dichroism (CD) signals at 440 nm and 530 nm ( Figure 4 Middle a), with UV absorption signal around 490nm ( Figure 4 in b).

[0076] The second step, chiral nanomaterials NiSx-L and H 2 O 2 The reaction between the two was verified: first, 200 μL of UAA@ZIF-8-NiSx(AZN) solution and 1 mL of OPD solution (0.1 mol / L) were added to a quartz cuvette, and mixed with a pipette to form a probe solution...

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Abstract

The invention discloses an optical sensor for multi-mode detection of hydrogen peroxide as well as a preparation method and application of the optical sensor. According to the method, the surface of a core-shell nanometer material with a porous ZIF-8 coated nanometer alloy UAAA structure is modified with a chiral nanometer material NiSx-L, the composite material UA (at) ZIF-8-NiSx is obtained, and the composite material has a chiral signal and a Raman hot spot at the same time and is used for qualitatively and quantitatively detecting H2O2 in a colorimetric / chiral / Raman three-sensing mode. In the presence of H2O2, as the chiral material is degraded, the CD signal of the chiral material is reduced along with the increase of H2O2. Meanwhile, under the catalysis of the UAAA (at) ZIF-8, o-phenylenediamine (OPD) modified on the surface of the UAAA (at) ZIF-8 can be quickly catalyzed by H2O2 to cause color change. In addition, under the detection of a Raman spectrometer, the Raman signal of the OPD also changes, so that the multi-mode detection of H2O2 is realized.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and in particular relates to an optical sensor used for multi-mode detection of hydrogen peroxide and a preparation method and application thereof. Background technique [0002] Hydrogen peroxide (H 2 O 2 ) is a major member of reactive oxygen species (ROS) species. So far, H 2 O 2 It is recognized as an important marker of oxidative stress in aging and various disease progression, and is involved in a wide range of physiological and pathological processes. As a potential biomarker, H 2 O 2 It is produced when non-phagocytic cells are stimulated by extracellular stimuli during disease progression. Under normal physiological conditions, low concentrations of H within the safe range of organelles 2 O 2 It can kill microorganisms and maintain the stability of cell function without causing harm to the human body. However, under pathological conditions, cells produce high conc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78G01N21/19G01N21/65
CPCG01N21/78G01N21/19G01N21/658
Inventor 周海波孙平华林晓玲周侠郭鑫杰田禾密
Owner JINAN UNIVERSITY
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