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Cefdinir dispersible tablet pharmaceutical composition and preparation process thereof

A technology of cefdinir and composition, applied in the field of pharmaceutical composition of cefdinir dispersible tablet and preparation field thereof, can solve the problems of poor stability, low bioavailability, slow disintegration and dissolution, etc., and achieve good compatibility , good hydrophilicity, good disintegration time effect

Pending Publication Date: 2022-07-01
BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, commercially available cefdinir preparations have defects such as slow disintegration and dissolution, low bioavailability, and poor stability.

Method used

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  • Cefdinir dispersible tablet pharmaceutical composition and preparation process thereof
  • Cefdinir dispersible tablet pharmaceutical composition and preparation process thereof
  • Cefdinir dispersible tablet pharmaceutical composition and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Preparation Example

[0022]

[0023] Preparation Process

[0024] 1) Weigh the appropriate proportion of cefdinir, microcrystalline cellulose, lactose, hydroxypropyl cellulose, calcium carboxymethyl cellulose, polyoxyl (40) stearate, aspartame, and orange powder flavor and mix well , Use a dry granulator for granulation, the granulation pressure is 40-60bar, and the number of whole grains is 14.

[0025] 2) Put the recipe amounts of silicon dioxide, magnesium stearate and the above particles into a three-dimensional mixer for total mixing.

[0026] 3) Press the tablet with a 9mm circular shallow concave punch.

Embodiment 2

[0027] Example 2: Preparation Example

[0028]

[0029] Preparation Process

[0030] 1) Weigh the appropriate proportion of cefdinir, microcrystalline cellulose, lactose, hydroxypropyl cellulose, calcium carboxymethyl cellulose, polyoxyl (40) stearate, aspartame, and orange powder flavor and mix well , Use a dry granulator for granulation, the granulation pressure is 40-60bar, and the number of whole grains is 14.

[0031] 2) Put the recipe amounts of silicon dioxide, magnesium stearate and the above particles into a three-dimensional mixer for total mixing.

[0032] 3) Press the tablet with a 9mm circular shallow concave punch.

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PUM

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Abstract

The invention relates to an oral pharmaceutical preparation of cefdinir dispersible tablets, and also relates to a preparation method of the oral pharmaceutical preparation. The cefdinir tablet is characterized by comprising the following components in parts by weight: 40-60 parts of cefdinir, 10-20 parts of lactose, 25-50 parts of microcrystalline cellulose, 2-5 parts of hydroxypropyl cellulose, 5-10 parts of calcium carboxymethyl cellulose, 1-5 parts of polyoxyl (40) stearate, 2-4 parts of orange powder essence, 3-10 parts of aspartame, 1-3 parts of silicon dioxide and 14.5-5 parts of magnesium stearate. According to the cefdinir dispersible tablet and the preparation method thereof, the calcium carboxymethyl cellulose in a specific proportion is used as the disintegrating agent, the magnesium stearate polyoxyl (40) ester in a specific proportion is used as the surfactant, and the prepared cefdinir dispersible tablet has good disintegration time limit, preparation stability and solubility and is equivalent to the original quality.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition of cefdinir dispersible tablets and a preparation method thereof. [0002] technical background [0003] Cefdinir is a third-generation oral cephalosporin, which has the advantages of broad antibacterial spectrum and low toxicity, and is widely used in clinical practice. At present, there are a variety of cefdinir preparations on the market in China, mainly including dispersible tablets, capsules, granules and tablets. Since cefdinir is a BCS class IV drug, its dissolution is a key factor for in vivo absorption. At present, the commercially available cefdinir preparations have defects such as slow disintegration and dissolution, low bioavailability and poor stability. Therefore, how to improve and improve the stability, disintegration performance and dissolution performance of cefdinir preparations, thereby improving preparation s...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/14A61K31/546A61P31/04
CPCA61K9/2095A61K9/2054A61K9/2031A61K31/546A61P31/04
Inventor 汲守信刘晓明杨晓波李利芳
Owner BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD
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