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Coronary gold-palladium nano heterogeneous material as well as preparation method and application thereof

A heterogeneous material, palladium nanotechnology, applied in nanotechnology, nano optics, nanotechnology, etc., can solve the problems of low photodynamic efficiency, can only eliminate tumors in situ, cannot completely remove metastatic cancer cells, etc., to promote maturation and activation, improving photothermal and photodynamic efficiency, and strong near-infrared light absorption

Active Publication Date: 2022-07-15
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to overcome the deficiencies of the prior art and solve the technical problems of low photothermal / photodynamic synergistic treatment of cancer with low photodynamic efficiency and can only eliminate tumors in situ but not completely remove metastatic cancer cells, the present invention provides a coronal gold-palladium nanoisocyanate Materials and their preparation methods and applications

Method used

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  • Coronary gold-palladium nano heterogeneous material as well as preparation method and application thereof
  • Coronary gold-palladium nano heterogeneous material as well as preparation method and application thereof
  • Coronary gold-palladium nano heterogeneous material as well as preparation method and application thereof

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Embodiment 1

[0045] The invention provides a photothermal and photodynamic synergistic treatment ability to kill in situ tumors, and utilizes the burr properties of the material itself and a large number of tumor-related antigens generated after phototherapy to induce specific cytotoxic T lymphocyte generation, effectively inhibiting the generation of specific cytotoxic T lymphocytes. Coronary gold-palladium nanoheteromaterials for tumor recurrence and metastasis. Wherein, the diameter of the gold nanorod is 10.9nm, the aspect ratio is 3.6, the length of the palladium protrusion is 11nm,

[0046] A preparation method of crown gold-palladium nano-heterogeneous material, comprising the following steps:

[0047]S1. Add hexadecyl pyridine chloride monohydrate into water and stir to dissolve until the solution is in a transparent state, and prepare a hexadecyl pyridine chloride monohydrate solution with a concentration of 1 mmol / L, and then heat the solution to 65℃ for later use;

[0048] S2,...

Embodiment 2

[0099] A preparation method of crown gold-palladium nano-heterogeneous material, comprising the following steps:

[0100] S1. Add hexadecyl pyridine chloride monohydrate into water and fully stir and dissolve until the solution is in a transparent state, prepare a hexadecyl pyridine chloride monohydrate solution with a concentration of 1 mmol / L, and then heat the solution to 65℃ for later use;

[0101] S2, add 2mL sodium tetrachloropalladate solution and 4mL gold nanorods to the solution heated in step S1, the concentration of sodium tetrachloropalladate solution is 10mmol / L, the absorbance value of nanogold rods is 1, the diameter is 10.9nm, the length The diameter ratio is 3.6;

[0102] Wherein, the nano-gold rods are prepared by the method of seed-mediated growth, including the following steps:

[0103] S2-1. Prepare gold seed solution:

[0104] Take 0.25mL of tetrachloroauric acid with a concentration of 10mmol / L and add it to 5mL of a solution of hexadecyltrimethylammo...

Embodiment 3

[0118] A preparation method of crown gold-palladium nano-heterogeneous material, comprising the following steps:

[0119] S1. Add hexadecyl pyridine chloride monohydrate into water and fully stir and dissolve until the solution is in a transparent state, prepare a hexadecyl pyridine chloride monohydrate solution with a concentration of 1 mmol / L, and then heat the solution to 65℃ for later use;

[0120] S2, add 2mL sodium tetrachloropalladate solution and 4mL gold nanorods to the solution heated in step S1, the concentration of sodium tetrachloropalladate solution is 100mmol / L, the absorbance value of nanogold rods is 1, the diameter is 10.9nm, the length The diameter ratio is 3.6;

[0121] Wherein, the nano-gold rods are prepared by the method of seed-mediated growth, including the following steps:

[0122] S2-1. Prepare gold seed solution:

[0123] Take 0.25mL of tetrachloroauric acid with a concentration of 10mmol / L and add it to 5mL of a solution of hexadecyltrimethylamm...

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Abstract

The invention discloses a coronal gold-palladium nano heterogeneous material as well as a preparation method and application thereof, belongs to the technical field of photosensitive nano materials, and solves the technical problems that the photodynamic efficiency is low and metastatic cancer cells cannot be completely removed during photothermal / photodynamic synergistic treatment of cancers. Wherein the existence form of the gold element is a nanogold rod, the existence form of the palladium element is a bulge, the palladium bulge irregularly grows on the outer surface of the nanogold rod, and the mass ratio of the gold element to the palladium element is 1: (0.1-0.5). The prepared coronal gold-palladium nano heterogeneous material is used in drugs for killing in-situ tumor cells and inhibiting tumor recurrence and metastasis under a near-infrared light excitation condition. The coronal gold-palladium nano heterogeneous material prepared by the invention can effectively improve the photo-thermal and photodynamic efficiency of the material, kill in-situ tumor cells, induce generation of specific cytotoxic T lymphocytes, and effectively inhibit recurrence and metastasis of tumors.

Description

technical field [0001] The invention belongs to the technical field of photosensitive nanometer materials, and in particular relates to a crown gold-palladium nanometer heterogeneous material and a preparation method and application thereof. Background technique [0002] Phototherapy has been widely used in the treatment of malignant tumors. Compared with conventional treatments such as surgery, radiotherapy, and chemotherapy, phototherapy has the advantages of non-invasiveness, low toxicity, high targeting, and few side effects. [0003] Phototherapy, mainly including photothermal therapy and photodynamic therapy, usually uses phototherapeutic agents to selectively kill tumor cells under light. PTT typically "burns" tumor cells using photothermal agents that generate high temperatures in the presence of light. PDT relies on laser irradiation of a specific wavelength to excite the photosensitizer, which in turn converts the surrounding oxygen molecules into reactive oxygen ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00A61P35/04B82Y5/00B82Y40/00B82Y20/00B22F9/24B22F1/00B22F1/054
CPCA61K41/0052A61K41/0057A61P35/00A61P35/04B82Y5/00B82Y40/00B82Y20/00B22F9/24
Inventor 冯艳林温兆阳宁鑫王建霖孙秀娟曹济民
Owner SHANXI MEDICAL UNIV
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