Niclosamide gel as well as preparation method and application thereof

Abstract

The invention discloses niclosamide gel as well as a preparation method and application thereof, and relates to the technical field of drugs for killing mollusks. According to the niclosamide gel, a gelatin aqueous solution with the mass volume concentration of 10 g / L or above serves as a gelling component, an active component niclosamide is loaded, and the niclosamide gel is formed by converting the gelling component into gel. The niclosamide gel overcomes the defects that an existing molluscicidal sustained-release agent is high in toxicity, prone to being influenced by dilution and scouring of rainwater, high in application concentration, incapable of continuously killing ampullaria gigas and prone to causing ecological environment problems. The niclosamide gel has a good slow release effect, can still keep an effective killing concentration for 20 days under a dilution condition, and has a better killing effect on ampullaria gigas and snail eggs; when the gel containing 0.1 mg / L of the molluscicide acts on the molluscicide for 48 hours, the death rate of the molluscicide can reach 50% or above, and the hatching rate of molluscicide eggs can be reduced to 30%; in addition, the niclosamide gel is easy to degrade, free of pollution and low in toxicity, and has high safety and environmental friendliness to the water environment where snails are located, especially fishes.

Description

technical field [0001] The invention belongs to the technical field of drugs for killing mollusks, and more particularly relates to a niclosamide gel and a preparation method and application thereof. Background technique [0002] Pomacea canaliculate (Pomacea canaliculate), also known as the big bottle snail, belongs to the phylum Mollusca and belongs to the species Ampullariidae. It is listed as one of the 100 malignant invasive alien species in the world, and it is also included in the "China's First Batch of Invasive Alien Species List" by my country. It is one of the first 16 alien species that invaded China. Fushou snail is divided into snail eggs, young snails and adult snails according to the growth stage. It has strong adaptability, rapid growth, high fecundity and lack of natural enemies. It has established natural populations in many provinces in southern my country, and is currently widely distributed and spreading. Fushou snails can eat a lot of rice seedlings. ...

AI Technical Summary

Problems solved by technology

Niclosamide is widely used in the world as a highly effective snail-killing drug, but its effective period is short, usually 7-10 days, and fish have low tolerance to the drug, so it cannot be used in the field involving aquatic planting areas. , after niclosamide is sprayed in places with snail ditches, ponds, grassy beaches with water, etc., it will be diluted in the water body and disappear soon, so it needs to be applied repeatedly, and the application concentration is high; for apple snail eggs, Due to the hard egg shell and strong stress resistance, it needs to be controlled more times and at a higher concentration than apple snails.

[0005] The existing technology mostly uses artificially synthesized polymers and biochar as carriers for molluscicide slow-release agents, but artificially synthesized polymers are often difficult to degrade, causing environmental hazards, and biochar will destroy the ecological beauty of freshwater waters and the visibility of water bodies For the prevention and control of snail eggs, the existing technology is to utilize high-concentration calcium chloride salt solution to suppress the hatching of apple snail egg pieces, but because calcium chloride can make the land salinized, the on-site use is greatly restricted; Chinese invention patent (open No.: CN1067515A) discloses tablets or pills for killing oncomelania, which will be washed by rainwater and gather in low-lying places when applied, and it is difficult to apply evenly. Compared with oncomelania, apple snails have higher fecundity, and their eggs have stress resistance. Strong drug resistance, after drug application, the surviving apple snail eggs can quickly hatch and recover, so the application of its dosage form is limited; Chinese invention patent (publication number: CN1432278A) discloses a suspension containing gelatin and niclosamide However, its composition is complex, and it is a kind of liquid that can flow. It is also easy to be washed away with the water flow, and it will deviate from the target mollusc killing area. It cannot guarantee the effectiveness and continuity of the drug effect on the target mollusc killing area. Therefore, , it is imminent to develop a sustainable and effective drug that is more ecological and environmentally friendly and can effectively kill apple snails and snail eggs

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