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Microemulsion foaming agent for treating psoriasis and preparation method thereof

A foaming agent and a technology for psoriasis are applied in the field of microemulsion foaming agent for the treatment of psoriasis and the preparation thereof, can solve the problems such as the inability to meet the treatment requirements, and achieve the effects of low production cost, simple preparation process and high safety

Pending Publication Date: 2022-07-29
ZHEJIANG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For refractory psoriasis such as moderate-to-severe psoriasis and pustular psoriasis, simple local application of the above-mentioned external medicines often cannot meet the treatment needs, and the combination with physical therapy such as phototherapy has been proven to have a good therapeutic effect

Method used

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  • Microemulsion foaming agent for treating psoriasis and preparation method thereof
  • Microemulsion foaming agent for treating psoriasis and preparation method thereof
  • Microemulsion foaming agent for treating psoriasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The present embodiment provides a preparation method of a microemulsion foam and investigates the therapeutic effect of the microemulsion foam on mice with psoriasis, including:

[0038] 1. Prepare a medicated microemulsion solution, mix chlorin e6 and isopropyl myristate in a ratio of 1:50 to obtain a medicated oil phase, mix caprylic acid capric acid macrogol glyceride and polyoxyethylene fat The acid ester is mixed in a ratio of 1:2 to obtain a mixed surfactant, the above-mentioned medicated oil phase and the mixed surfactant are mixed in a ratio of 3:5, stirred with a magnetic stirrer at a rotational speed of 500 rpm, and added dropwise to Ionized water, so that the volume ratio of medicated oil phase, mixed surfactant and deionized water is 3:5:5 to form a uniform microemulsion solution a.

[0039] 2. Put the microemulsion solution a into a container with a sieve pump head, and spray it with a spray head to obtain foam.

[0040] 3. Investigation on the treatment o...

Embodiment 2

[0051] The present embodiment provides a preparation method of a microemulsion foam and investigates the therapeutic effect of the microemulsion foam on mice with psoriasis, including:

[0052] 1. Prepare a drug-containing microemulsion solution, mix talaporfin and diethylene glycol monoethyl ether in a ratio of 1:100 to obtain a drug-containing oil phase, mix polyglycerol oleate and polyoxyethylene sorbitan fatty acid The ester is mixed in a ratio of 1:5 to obtain a mixed surfactant, the above-mentioned medicated oil phase and the mixed surfactant are mixed in a ratio of 1:6, stirred with a magnetic stirrer at a rotating speed of 1000 rpm, and deionized is added dropwise. water, so that the volume ratio of the medicated oil phase, mixed surfactant and deionized water is 1:6:8 to form a uniform microemulsion solution a.

[0053] 2. Put the microemulsion solution a into a container with a sieve pump head, and spray it with a spray head to obtain foam.

[0054] In this embodime...

Embodiment 3

[0059] The present embodiment provides a preparation method of a microemulsion foam and investigates the therapeutic effect of the microemulsion foam on mice with psoriasis, including:

[0060] 1. Prepare a medicated microemulsion solution, mix porfimer sodium and squalane at a ratio of 1:80 to obtain a medicated oil phase, and mix oleoyl polyoxyethylene glyceride and caprylic capric acid polyethylene glycol glyceride with Mixing in a ratio of 2:3 to obtain a mixed surfactant, mixing the above-mentioned medicated oil phase and the mixed surfactant in a ratio of 4:15, stirring with a magnetic stirrer at a rotating speed of 800 rpm, and adding deionized water dropwise, The volume ratio of the medicated oil phase, the mixed surfactant and the deionized water is 4:15:20 to form a uniform microemulsion solution a.

[0061] 2. Put the microemulsion solution a into a container with a sieve pump head, and spray it with a spray head to obtain foam.

[0062] In this embodiment, porfime...

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Abstract

The invention discloses a microemulsion foaming agent for treating psoriasis. The microemulsion foaming agent comprises a surfactant, a cosurfactant, an oil phase, a water phase and a photosensitizer drug. The invention also provides a preparation method of the microemulsion foaming agent for treating psoriasis, which comprises the following steps: 1) preparing a drug-containing microemulsion solution: mixing the photosensitizer drug with the compatible oil phase or water phase, mixing the cosurfactant with the surfactant, mixing the mixture of the oil phase and the surfactant with the water phase according to a ratio, and uniformly stirring to obtain the drug-containing microemulsion solution; stirring and mixing to form a uniform drug-containing microemulsion solution; and 2) filling the drug-containing microemulsion solution into a container, and spraying the drug-containing microemulsion solution by a pump head containing a screen to form foam. The micro-emulsion foaming agent provided by the invention has the advantages of high efficiency, safety, simplicity in preparation, convenience in use and comfort in use.

Description

technical field [0001] The invention belongs to the technical field of microemulsion foams, in particular to a microemulsion foam for treating psoriasis and a preparation method thereof. Background technique [0002] Psoriasis is a chronic skin disease characterized by erythema, scaling, and epidermal thickening. Its pathogenesis is complex, the course of disease is long, it is easy to relapse, and it is difficult to cure, which has a great impact on the physical and mental health of patients. Psoriasis can be divided into psoriasis vulgaris, pustular, erythrodermic, and arthrotic psoriasis according to the location and characteristics of the disease. Among them, psoriasis vulgaris (also known as plaque psoriasis) is the most common. Accounts for 90% of the incidence of psoriasis. [0003] For psoriasis, local, physical and systemic treatments are mainly used in clinical practice to inhibit keratinocyte proliferation and regulate the immune system. Common topical medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K41/00A61K47/14A61P17/06A61P19/02
CPCA61K41/0071A61K9/122A61K41/0061A61K9/0014A61K47/14A61P17/06A61P19/02
Inventor 高建青马晓鹿边琼李平
Owner ZHEJIANG UNIV