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Preparation method for synthesizing magnetic polymer microspheres through chemical copolymerization

A technology of polymer microspheres and copolymerization, which is applied in the preparation of microspheres, the magnetism of organic materials/organic magnetic materials, and microcapsule preparations. The diameter is controllable, easy to control, and the effect of atomization impact is small

Pending Publication Date: 2022-07-29
南京亘闪生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Therefore, in view of the above content, the present invention provides a method for preparing magnetic polymer microspheres by chemical copolymerization, which solves the problems of easy magnetic loss and wide particle size distribution of magnetic fluids in the prior art.

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  • Preparation method for synthesizing magnetic polymer microspheres through chemical copolymerization

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Embodiment 1

[0035] A method for preparing magnetic polymer microspheres by chemical copolymerization, comprising the following steps:

[0036] (1) Preparation of magnetic fluid:

[0037] The ferric chloride is added to ethylene glycol to prepare a solution of 0.01mol / L; then ferrous chloride is added, and the molar ratio of the ferrous chloride to the ferric chloride is 0.1:2, and the mixture is uniformly stirred and then transferred. In a hydrothermal reactor, react at 200°C for 22 hours; after the reaction, cool to room temperature, centrifuge, wash and dry to obtain a ferrofluid containing hydroxyl groups on the surface;

[0038] (2) Post-modification of olefinic magnetic fluid:

[0039] Add the ferrofluid obtained in step (1) into toluene, stir until the ferrofluid is evenly dispersed, add 3-methacryloyloxypropyltrimethoxysilane, and react under reflux for 24h; the reaction ends After centrifugation, washing and drying, the alkene-modified triferrous tetroxide magnetic fluid can be ...

Embodiment 2

[0047] A preparation method of chemical copolymerization into magnetic polymer microspheres:

[0048] (1) Preparation of magnetic fluid:

[0049] The ferric nitrate was added to the ethylene glycol to prepare a solution of 0.10 mol / L; then ferrous nitrate was added, and the molar ratio of the ferrous nitrate to the ferric nitrate was 0.05:2, and after stirring and mixing, it was transferred to the hydrothermal reaction In the kettle, react at 220°C for 24h; after the reaction, cool to room temperature, centrifuge, wash and dry to obtain the ferrofluid containing hydroxyl groups on the surface;

[0050] (2) Post-modification of olefinic magnetic fluid:

[0051] Add the ferrofluid obtained in step (1) into toluene, stir until the ferrofluid is evenly dispersed, add 3-methacryloyloxypropyltriethoxysilane, and react under reflux for 24h; After the completion of centrifugal separation, washing and drying, the olefinic modified triferrous tetroxide magnetic fluid can be obtained; ...

Embodiment 3

[0058] A preparation method of chemical copolymerization into magnetic polymer microspheres:

[0059] (1) Preparation of magnetic fluid:

[0060] The ferric nitrate was added to the ethylene glycol to prepare a solution of 0.35mol / L; then ferrous nitrate was added, and the molar ratio of the ferrous nitrate to the ferric nitrate was 0.5:2, and the mixture was uniformly stirred and then transferred to the hydrothermal reaction. In the kettle, react at 250°C for 18h; after the reaction, cool to room temperature, centrifuge, wash, and dry to obtain the ferrofluid containing hydroxyl groups on the surface;

[0061] (2) Post-modification of olefinic magnetic fluid:

[0062] Add the triferrous tetroxide magnetic fluid obtained in step (1) into toluene, stir until the triferrous tetroxide magnetic fluid is uniformly dispersed, add 3-methacryloyloxypropylmethyldiethoxysilane, and react under reflux for 24h ; After the reaction, centrifugal separation, washing and drying can be obtai...

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Abstract

The invention relates to the technical field of polymer materials, and provides a preparation method for synthesizing magnetic polymer microspheres through chemical copolymerization, which comprises the following steps: (1) preparing magnetic fluid; (2) carrying out post-modification on the olefin magnetic fluid; (3) preparing a stable phase; (4) carrying out ultrasonic atomization on the copolymerized oil phase; and (5) polymerizing. The problems that magnetic fluid in the prior art is prone to loss in magnetism and wide in particle size distribution are solved. The magnetic polymer microspheres synthesized by the method can be used in the fields of biological separation, nucleic acid extraction, in-vitro diagnosis, in-vivo imaging and the like.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a method for preparing magnetic polymer microspheres by chemical copolymerization. Background technique [0002] So far, magnetic microspheres have been widely used in biological separation, nucleic acid extraction, in vitro diagnosis and in vivo imaging due to their operability, modifiability, easy labeling, low toxicity or non-toxicity and special relaxation properties. It has become an indispensable tool for modern biomedical research and clinical applications. [0003] At present, the preparation methods of magnetic microspheres mainly include monomer polymerization (Xu ZZ, Xia A, Wang C C, et al. Synthesis of raspberry-like magnetic polystyrene microspheres [J]. Materials Chemistry and Physics, 2007, 107(2): 494 -499.), swelling method (Ugelstad J, Berge A, Ellingsen T. Preparation and application of new monosized polymerparticles. Pro Polym Sci, 1992, 17:87-161) ...

Claims

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Application Information

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IPC IPC(8): C08F292/00C08F212/08C08F212/36C08F220/14C08F222/14C08F212/14C08F220/32C08F222/20C08F220/20B01J13/14H01F1/42
CPCC08F292/00B01J13/14H01F1/42C08F212/08C08F212/36C08F220/14C08F222/102C08F212/18C08F220/325C08F220/20
Inventor 仲玉任连兵丁士忠
Owner 南京亘闪生物科技有限公司
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