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Method for improving surface biological activity and osseointegration performance of polyether-ether-ketone base material

A polyetheretherketone and substrate surface technology, applied in the field of materials, can solve problems such as inability to mineralize, and achieve the effect of improving biocompatibility and good mechanical stability

Active Publication Date: 2022-07-29
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of inducing biomimetic mineralization proposed in the patent CN107115565A can perform biomimetic induced mineralization on the surface of various substrates, but this method still cannot mineralize the surface of polyether ether ketone substrates

Method used

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  • Method for improving surface biological activity and osseointegration performance of polyether-ether-ketone base material
  • Method for improving surface biological activity and osseointegration performance of polyether-ether-ketone base material
  • Method for improving surface biological activity and osseointegration performance of polyether-ether-ketone base material

Examples

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Embodiment 1

[0041] The embodiments of the present invention provide a method for improving the surface bioactivity and osseointegration performance of PEEK substrates.

[0042] Tris(2-carboxyethyl) phosphine solution with a concentration of 50mmol / L, after adjusting the pH value to 4-6 with NaOH, and bovine serum albumin solution with a concentration of 2mg / mL in a ratio of 1:10 to 10:1 Mix to make a mixed solution. It should be noted that the concentration of tris(2-carboxyethyl)phosphine in the tris(2-carboxyethyl)phosphine solution can be any concentration in the range of 0.05-600 mM, and the concentration of bovine serum albumin in the bovine serum albumin solution can be Any concentration in the range of 0.05-500 mg / mL, the higher the concentration of each reactant, the thicker the resulting two-dimensional protein nanofilm, and the too low protein concentration will make the resulting two-dimensional protein nanofilm less dense.

[0043] A PEEK substrate with a size of 1 cm × 1 cm ...

Embodiment 2

[0047] The invention provides a method for improving the surface biological activity and osseointegration performance of PEEK substrate.

[0048]The steps in this example are basically the same as those in Example 1, except that the mixture used in the preparation of the PEEK substrate modified by the protein two-dimensional nanofilm is 2 mg / mL lysozyme and 7 mg / mL cysteine ​​in a ratio of 1: It is mixed in a ratio of 10-10:1, and the standing time is 1h.

[0049] The hydroxyapatite coating on the surface of the PEEK substrate prepared in this example is as follows after being characterized by SEM. figure 1 shown.

Embodiment 3

[0051] The invention provides a method for improving the surface biological activity and osseointegration performance of PEEK substrate.

[0052] The steps in this example are basically the same as those in Example 1, except that the mixture used in the preparation of the PEEK substrate modified by the protein two-dimensional nanofilm is 2 mg / mL lysozyme and 50 mM TCEP at a ratio of 1:10 to 10:1 The ratio is mixed, and the standing time is 1h.

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Abstract

The invention relates to a method for improving surface bioactivity and osseointegration performance of a polyether-ether-ketone base material, which sequentially comprises the following steps: (1) soaking the polyether-ether-ketone base material in a mixed solution of a protein solution and a disulfide bond reducing agent to obtain a nano-film modified polyether-ether-ketone base material; and (2) soaking the nano-film modified polyether-ether-ketone base material obtained in the step (1) in a calcium-phosphorus solution, and performing closed incubation to obtain the hydroxyapatite coating modified polyether-ether-ketone base material. According to the method for improving the surface biological activity and bone integration performance of the PEEK base material, the problem that in the prior art, induced mineralization cannot be conducted on the surface of the PEEK base material is solved, and the modified PEEK base material can serve as a tissue repair material to induce formation of new tissues and mineralization of bones; the material is expected to become a novel hard tissue substitute material.

Description

technical field [0001] The invention mainly relates to the field of materials, in particular to a method for improving the surface bioactivity and osseointegration performance of a polyetheretherketone substrate. Background technique: [0002] As a semi-crystalline linear polycyclic aromatic polymer, polyetheretherketone (PEEK) material was first used in clinical implants in 1998. Due to its excellent chemical resistance, good mechanical strength and radiation permeability, it has become increasingly popular in orthopaedics as an alternative to titanium and its alloys in recent years. As an implant material, the main advantage of PEEK is that the elasticity and strength thresholds are very close to cortical bone. The elastic modulus of PEEK is in the range of 3-4GPa, and the elastic modulus of human cortical bone is about 18GPa. Moreover, it has been reported that the elastic modulus of carbon fiber reinforced PEEK composites is close to that of cortical bone (about 18-25 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/04C08J7/06C08L61/16A61L27/18A61L27/32A61L27/34A61L27/50
CPCC08J7/0423C08J7/06A61L27/18A61L27/32A61L27/34A61L27/50C08J2361/16C08J2489/00A61L2430/02A61L2420/02A61L2420/08A61L2400/18A61L2400/12C08L61/16
Inventor 杨鹏张旭高颖涛逄艳云
Owner SHAANXI NORMAL UNIV
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